Navigation Links
Diaphragms offer no extra protection Against HIV

A report in medical journal The Lancet, reveals another disappointing find in the search for a device to curb HIV infection in women.

Nancy Padian, executive director of the UCSF Women's Global Health Imperative, and team say that the female condom used in conjunction with the male condom is in no way superior to the latter, in preventing infection by HIV virus.

The team, also part of the Methods for Improving Reproductive Health in Africa (MIRA), did a randomized trial of almost 5,000 sexually active, HIV-negative women in South Africa and Zimbabwe. "Although the intervention seemed safe, our findings do not support addition of the diaphragm to current HIV-prevention strategies, the researchers write.

This trial was part of the $37-million clinical trial funded by the Bill and Melinda Gates Foundation in Africa. The news that the diaphragm, a sort of contraceptive device worn tightly to shield the cervix, failed to prevent HIV infection, is the latest in a growing list of disappointing efforts to curb the AIDS menace. The study was the most closely watched HIV prevention trial for women since January, when researchers abruptly ended studies of a vaginal gel meant to block the virus after early results showed the women who used it had a slightly higher risk of becoming infected.

A similar trial testing whether the contraceptive jelly nonoxynol-9 might work as an anti-HIV microbicide, failed in 2000, when the study revealed that prostitutes in South Africa who used it had a significantly higher infection rate than those who were given an inactive placebo gel.

"It's very, very disappointing, of course, Padian was quoted. "We were hoping to find a protective effect. ... It's taken me a long time to get over how devastating this is", she added. Researchers are desperately seeking a low-cost method that women could use (without the consent of male partners) to protect themselves against HIV.

The stud y was conducted in Durban and Johannesburg, South Africa, and in Harare, Zimbabwe. It enrolled nearly 5,000 women ages 18-49 and followed them an average of 18 months. Half of the women were given diaphragms and a gel lubricant, while the other half were not. Both groups were also given condoms and extensive counseling to have their partners use them. By the end of the study, HIV infection rates were high and almost identical: about 4 percent of the women in each arm of the study were infected per year. Infections were found in 158 women given diaphragms and condoms and counseling; 151 women were infected among those given condoms and counseling only.

Accordingly, about 20 percent of adults are infected in Zimbabwe and South Africa, where the experiment was conducted. Women there run twice the risk of infection as men. In cultures where women are traditionally subservient to men, they have less of a say about matters of sex - when to have it, whom to have it with, and whether condoms or other safer sexual practices will be used.

Padian said one of the more surprising and disappointing results was that the women provided diaphragms reported using them only 70 percent of the time. That finding nevertheless provides valuable information about the importance of monitoring compliance in complex trials such as this one, she says.

Since 1994, Padian and her team of researchers had been exploring the possibility that diaphragms might protect against the AIDS virus. The theory held that the cervix - which can be shielded from semen by a diaphragm - is the most vulnerable part of the female reproductive tract to HIV infection. Yet now, the diaphragm in the use of HIV-prevention, may well be history. Padian was quoted that the diaphragm does not warrant being used as a protective device now.


'"/>




Related medicine news :

1. Pharmaceutical giant offers AIDS related antifungal drug free to 50 countries
2. Pharmaceutical giant offers AIDS related antifungal drug free to 50 countries
3. Magnesium sulfate offers no help in migraine treatment
4. Stem cells offer hope for muscular dystrophy
5. Monkeys offer genetic clues to adult blindness
6. Arthiritis: Brightly-coloured fruit and vegetables offer protection
7. New Infertility test to be offered by Reliance
8. Wrinkle reduction cream has offered insights into working of nervous system
9. ESRC offers new dynamics for old in UK
10. Roche offers HIV drug expertise to poor nations
11. Genetically modified Lactic acid bacteria offers HIV protection
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research and Markets ... for Companion Diagnostic Tests" report to their offering. ... Companion Diagnostics The World Market for Companion ... medicine diagnostics. Market analysis in the report includes the following: ... (In Vitro Diagnostic Kits) by Region (N. America, EU, ROW), ...
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
(Date:6/23/2016)... Research and Markets has announced the addition ... Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, Binder, ... Forecast to 2021" report to their offering. ... excipients market is projected to reach USD 8.1 Billion ... forecast period 2016 to 2021. The ...
Breaking Medicine Technology: