Navigation Links
Diabetes Drug Dramatically Boosts Potency of Platinum Chemotherapy

type 2 diabetes to help control blood sugar levels. An estimated 5 million people in the U.S. take Avandia or a similar drug, piozitaglone, which is sold as Actos.

Both drugs work by activating PPAR-gamma, a transcription factor that functions as a master regulator of fat development in the body, a function discovered in the Spiegelman lab in 1994. Spiegelman and others observed that certain PPAR-gamma-activating compounds, called PPAR-gamma ligands, caused cancer cells to stop growing and become more mature, or differentiated. Therefore, Spiegelman and others felt it was a logical step to try PPAR-gamma ligands as cancer treatment, but several small clinical trials found rosiglitazone alone was ineffective against several cancer types.

Despite this setback, and because rosizitaglone was well-tolerated by patients compared to standard cancer drugs, Dana-Farber researchers believed it was worthwhile to try it and similar PPAR-gamma ligands in a different context, said Geoffrey Girnun, PhD, a researcher in Spiegelman's laboratory and lead author of the Cancer Cell report. "After discussing it with other Dana-Farber researchers, we decided to try these agents in combination with platinum-based drugs, and in several different cell lines, we saw positive results," said Girnun.

In addition to rosizitaglone, the scientists tested pioglitazone and an experimental compound made by Glaxo Smith Kline, combining each of them with cisplatin, carboplatin and oxalyplatin -- all commonly used chemotherapy drugs that destroy cancer cells by damaging their DNA.

When non small-cell lung cancer cell lines were treated with rosizitaglone alone, there was no effect on growth. Carboplatin alone reduced growth of the cancer cells by about 60 percent. But when both drugs were administered, cell growth was reduced by 80 percent. The drugs were also tested individually and together on ovarian cancer cell lines that normally are resistant to chemoth
'"/>




Page: 1 2 3

Related medicine news :

1. Is Diabetes the Leading Cause of Kidney Failure in India
2. Diabetes and Depression often go hand-in-hand
3. Thirty minutes of work up per day reduces the risk of Diabetes
4. Diabetes on the rise
5. Irregular Periods Linked to Diabetes
6. Cinnamon combats Diabetes
7. Good News For Women With Gestational Diabetes
8. Processed Meat, Diabetes connection Found
9. Pancreatic Cancer may be linked to Diabetes
10. Gestational Diabetes linked to Chromosomal defici
11. A way to slow the progression of Type 1 Diabetes
Post Your Comments:
(Date:12/21/2014)... 21, 2014 SCI explores ... issues and systemic barriers for disabled athletes with ... Scheidies has a condition called juvenile macular degeneration, where ... how he adapted his athletic ambitions to his vision ... in triathlon to pioneer the way for other blind ...
(Date:12/21/2014)... Concept Plus, LLC. a SDB and ... Fairfax, VA., today announced it has been recognized by ... which ranks the fastest growing government contracting small businesses by ... , This is the first year that Concept Plus, LLC., ... with a 95.92% compound annual growth rate. “For Concept Plus ...
(Date:12/20/2014)... NY (PRWEB) December 20, 2014 An ... healthcare sector have benefited the Massage Services ... discretionary characteristics of industry products, the anticipated 1.0% annualized ... period has provided consumers with the means to afford ... have received a massage in a given year has ...
(Date:12/20/2014)... Recently, VogueQueen.com, a leading wedding dress wholesaler ... Online for 2015. Great discounts are now offered ... consumers can get a discount, up to 80% off, ... before January 30, 2015. , VogueQueen.com has recently released ... prom dress promotion. Many customers worldwide like VogueQueen’s special ...
(Date:12/20/2014)... (PRWEB) December 20, 2014 The aftermath of ... quite a stir, not only in Hollywood, but worldwide. ... 18th , the ripples of that attack are starting a ... jobs at risk. But they are not the only ... could be in for some embarrassing times ahead, agents and ...
Breaking Medicine News(10 mins):Health News:Disability in Sports on SCI TV with Triathlon World Champ Aaron Scheidies 2Health News:Disability in Sports on SCI TV with Triathlon World Champ Aaron Scheidies 3Health News:Concept Plus, LLC. Named One of Washington Technology’s Fast 50 2Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:VogueQueen Big Sale Online For The Coming 2015 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 3Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 4Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 5
... Behavioral scientist and tobacco-cessation expert, Alexander V. Prokhorov, M.D., ... Center is the recipient of the 2011 American Society ... for Excellence in Tobacco Research. "I,m humbled by ... dedication, innovative programs and collaboration with health care professionals, ...
... , WEDNESDAY, Dec. 8 (HealthDay News) -- Omega-3 fatty acids ... of fatty acid called DHA is used in the right ... study suggests. The researchers analyzed the results of some ... -- commonly found in oily fish or in fish oil ...
... health researchers at Indiana University found that women who ... satisfaction and pleasure. The study, involving 2,453 women, ... the widespread commercial availability of lubricant and the gaps ... contributing to other health issues. "In spite of ...
... large European study suggest that poorly educated people are more ... than the better educated, even after differences in lifestyle have ... (Thursday 9 December) in the European Heart Journal ... as 31 years (range 0-31 years, average follow-up was 21 ...
... survive an episode of mechanical ventilation during a hospitalization ... leaving the hospital than those who survive hospitalization without ... Pittsburgh. These results were borne out even though the ... in both groups. The study was published online ...
... recommended to decrease the incidence of urinary tract infections, ... trials. However, a new study published in the ... and now available online ( http://cid.oxfordjournals.org/content/52/1/23.full ), suggests otherwise. ... urinary tract infection were assigned to drink eight ounces ...
Cached Medicine News:Health News:Cancer prevention expert honored for innovative tobacco research 2Health News:Certain Formulations of Omega-3s Might Help With Depression 2Health News:Certain Formulations of Omega-3s Might Help With Depression 3Health News:Study examines effect of water-based and silicon-based lubricant 2Health News:Study examines effect of water-based and silicon-based lubricant 3Health News:Lower levels of education are associated with increased risks of heart failure 2Health News:Lower levels of education are associated with increased risks of heart failure 3Health News:Lower levels of education are associated with increased risks of heart failure 4Health News:Older survivors of mechanical ventilation can expect significant disability 2Health News:Older survivors of mechanical ventilation can expect significant disability 3
(Date:12/19/2014)... Ill. , Dec. 19, 2014   Hospira, ... leading provider of injectable drugs and infusion technologies, today ... Morgan 33rd Annual Healthcare Conference on Wednesday, Jan. 14, ... presentation is scheduled to begin at 10:30 a.m. Pacific ... available to all interested parties through a live audiocast ...
(Date:12/19/2014)... CARDIFF-BY-THE-SEA, Calif. , Dec. 19, ... SRNE ;  Sorrento), an oncology company developing new ... Inc., a privately-held immuno-oncology company developing proprietary Neukoplast ... based therapy, announced today that the companies have ... next generation CAR-TNK™ (pronounced as "Car-Tank") immunotherapies for ...
(Date:12/19/2014)... LOS ALTOS, Calif. , Dec. 18, 2014 ... of a new generation of equipment for the ... today the release of the new Luminary™ Profiler, ... highly accurate light-based measurement in a cost-effective, portable ... to meet the specific needs of the cannabis ...
Breaking Medicine Technology:Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2
... October 12, 2011 Leading health ... titles freely available through UN developing world research access ... scientific, technical and medical information products and services, today ... books to Research4Life , a public-private partnership working ...
... Mass., Oct. 11, 2011 Boston Scientific Corporation (NYSE: ... results for the third quarter ended September 30, 2011 on ... call will be hosted by Hank Kucheman, who becomes Boston ... Executive Vice President and Chief Financial Officer. A ...
Cached Medicine Technology:Elsevier Offers 950 New Health Titles to Research4Life 2Elsevier Offers 950 New Health Titles to Research4Life 3Boston Scientific To Webcast Conference Call Discussing Third Quarter 2011 Financial Results 2
Slightly curved blunt dissector, double-ended. Length 11 1/2" (272 mm)...
Leroy-Raney scalp clips, sterile, disposable, plastic, ten clips/package....
Disposable scalp clip applier, comes loaded with 12 Leroy-Raney clips, ergonomic, easy to handle and position the clip....
... of comminution, aspiration and irrigation ... ultra-sonic energy. Allows for preservative ... particular, parenchymatous organs, offering the ... non-traumatic preparation with a low ...
Medicine Products: