Navigation Links
Diabetes Drug Dramatically Boosts Potency of Platinum Chemotherapy

A widely used diabetes drug dramatically boosted the potency of platinum-based cancer drugs when administered together to a variety of cancer cell lines and to mice with tumors, scientists from Dana-Farber Cancer Institute report.

Combining a platinum chemotherapy agent and the diabetes drug rosiglitazone halted or shrank mouse tumors as much as three times more effectively than either of the drugs given alone, according to the article in the May issue of Cancer Cell.

If pairing the drugs has the same synergistic effect in humans, the researchers say, it could improve control of ovarian, lung and other cancers routinely treated with platinum-based chemotherapy, to which tumors eventually become resistant. Moreover, the experiments suggest the combination might extend the use of platinum drugs to other cancers where they haven't previously been shown to be effective.

"There's still a huge gulf between these experiments and human cancers," said Bruce Spiegelman, PhD, senior author of the report. "But it's worked in every animal model of cancer weve looked at, and I think theres a fair chance it will help people."

Dana-Farber researchers are already drawing up plans for initial clinical trials, which could begin sometime this year.

"We really see a way forward here to improve the chemotherapy's effectiveness for multiple forms of cancer," said George Demetri, MD, a Dana-Farber researcher who is preparing a proposal for a pilot study of rosizitaglone and platinum chemotherapy drugs in lung and ovarian cancer and sarcomas.

If a pilot study shows promising activity, the combination would need to be compared with standard chemotherapy in larger phase 2 and phase 3 trials involving many hundreds of patients.

Rosizitaglone, sold under the name Avandia, enhances insulin receptors' sensitivity in diabetics whose pancreas secretes too little insulin. It was approved in 1999 for use by patients with
'"/>




Page: 1 2 3

Related medicine news :

1. Is Diabetes the Leading Cause of Kidney Failure in India
2. Diabetes and Depression often go hand-in-hand
3. Thirty minutes of work up per day reduces the risk of Diabetes
4. Diabetes on the rise
5. Irregular Periods Linked to Diabetes
6. Cinnamon combats Diabetes
7. Good News For Women With Gestational Diabetes
8. Processed Meat, Diabetes connection Found
9. Pancreatic Cancer may be linked to Diabetes
10. Gestational Diabetes linked to Chromosomal defici
11. A way to slow the progression of Type 1 Diabetes
Post Your Comments:
(Date:1/22/2015)... January 22, 2015 Four years since the release ... which coincided with the marriage of Avasa & Matthew Love – ... which is scheduled for release through White Swan Records on February ... there is a sacred path available to all of us to ...
(Date:1/22/2015)... Mass. (PRWEB) January 22, 2015 EBSCO ... (AMA) are expanding their relationship in an effort to ... around the world. While EBSCO has long made AMA journals ... a sales agent for The JAMA Network. , ...
(Date:1/22/2015)... JJsHouse.com is a famous dress online store for ... its latest collection of wedding dresses , and launches ... is the wedding dress on your big day; the wedding ... Every bride wants to find the most suitable wedding dress. ...
(Date:1/22/2015)... Lower-Auto-Insurance.com has released a new blog post explaining the ... reducing the costs of an auto insurance policy . ... get lower prices for their vehicle insurance policies. The safety a ... policy costs. Because of this, drivers should always carry a ...
(Date:1/22/2015)... 22, 2015 State Forestry Institute of ... system with support from GEOSYSTEMS, a dedicated Hexagon Geospatial ... will leverage Hexagon Geospatial’s ERDAS APOLLO for ... well as point clouds and documents. This effort will ...
Breaking Medicine News(10 mins):Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 3
... grant support, investigators at Nationwide Children,s Hospital plan to ... leads to the development of a devastating brain tumor, ... Center for Childhood Cancer at The Research Institute at ... the Matthew Larson Foundation for this research. ...
... 1 (HealthDay News) -- Screening college athletes for heart conditions ... sudden cardiac death, according to a new study. ... heart abnormality or symptoms that required further screening, prompting researchers ... in sports. Every year in the United States, 60 ...
... Gardner HealthDay Reporter , WEDNESDAY, June 1 ... researchers were able to find previously undetected changes in ... had been diagnosed with mild brain injuries sustained from ... "absolutely not there yet," Christine Mac Donald, lead author ...
... a newer, more precise form of radiation therapy, ... hormone therapy than using three-dimensional radiation therapy, according ... of the International Journal of Radiation OncologyBiologyPhysics ... Society for Radiation Oncology (ASTRO). Three-dimensional radiation ...
... -- Newly diagnosed cancer patients frequently face hurdles in ... to new research from the Perelman School of Medicine ... Saturday, June 4 at the 2011 annual meeting of ... with private health insurance had difficulty scheduling an appointment, ...
... MAYWOOD, Ill. -- Baseline concussion tests given to hundreds ... some cases, according to a Loyola University Health System ... rate, meaning a test shows an athlete has recovered, ... cognitive impairments from the concussion. This could increase risks ...
Cached Medicine News:Health News:New grant to study how pediatric brain tumor, ependymoma, develops 2Health News: Experts Recommend Cardiac Screening for College Athletes 2Health News:Hi-Tech Scan Detects Soldiers' Head Injuries 2Health News:Hi-Tech Scan Detects Soldiers' Head Injuries 3Health News:Two-thirds of newly diagnosed cancer patients unable to obtain oncology appointments 2Health News:Does baseline concussion testing really reduce risks to athletes? 2
(Date:1/23/2015)... LOS ANGELES , Jan. 23, 2015 A lot ... the best methods for treating  certain illnesses, injuries, or conditions. ... to replace previous treatment methods with ones that they consider ... treating hernias, there is not one textbook method of treatment ...
(Date:1/23/2015)...  MedScope ( www.medscope.org ), the leading provider of medical ... Connected World magazine Connected World Award for its ... be used anywhere, anytime. The nomination was made by ... nominating MedScope, Landon Garner , Director of Marketing ...
(Date:1/23/2015)... Fla. , Jan. 23, 2015  HyGreen, Inc., a ... agreement and partnership with RCA Medical, a subsidiary of ... . Each year, hundreds of millions ... care-associated infections as organisms are transmitted from patient to ...
Breaking Medicine Technology:No One-Size-Fits-All Remedy for Hernia Correction 2MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2HyGreen Partners with RCA Medical in Johannesburg, South Africa 2
... Ill., April 19, 2011 Sysmex, a global ... systems technology, announced today an amended distributorship agreement ... automatically renews for up to four successive one-year ... including the Sysmex pocH-100 i™ , Sysmex KX-21N™, ...
... Premier Research Group Limited announces the re-branding of ... Research Company. With the continued growth in clinical development ... the medical device industry, Premier Research recognises this sector ... D-TARGET was founded in 1997 and acquired ...
Cached Medicine Technology:Sysmex America Signs Distributorship Agreement With LABSCO 2Premier Research Re-brands its Medical Device Business Unit to D-TARGET 2
4 mm wide tip....
Double-ended. Blunt and semi sharp 5 mm tips. Designated most popular model or size....
Double-ended. Designated most popular model or size....
Designated most popular model or size. Double-ended. 2 mm wide....
Medicine Products: