Navigation Links
Developmental Origins of Polycystic Ovarian Syndrome

A recent study has revealed that the way a baby girl develops in a womb may adversely affect// chances of developing polycystic ovarian syndrome (PCO) as adults. Dr Michael Davies, senior researcher at the Research Center of Reproductive Health at the University of Adelaide, Australia headed this study. Dr Davies and his team studied a group of young women bon between 1973 and 1975. They decided to first contact the mothers from maternity hospital records and then interview the daughters. So far 544 women have been interviewed, all who are aged between 30 and 32. The study included a detailed report on the medical history as well as birth details. The details also included birth weight, placental weight, and so on. After a wide comparison Dr Davies said: "Symptoms of PCOS were relatively common. One in five women had more facial and/or body hair than normal, and one in four reported menstrual irregularity of greater than four days. Five per cent of women reported that they had an existing diagnosis of PCOS. We examined maternal weight in late pregnancy, birth weight and placental weight in relation to the symptoms of PCOS, or an existing or putative diagnosis of PCOS. Compared with their counterparts, young women without a diagnosis of PCOS but with irregular periods were heavier at birth, with larger placentas, and they tended to have mothers who were heavier in late pregnancy. In contrast, women with an existing diagnosis of PCOS tended to have birth weights that were, on average, 196g lighter than women without PCOS and smaller placentas”.

He further said, “Therefore, our data suggest that different developmental pathways are implicated in the overlapping symptoms of PCOS. One pathway may be mediated by high maternal weight in late pregnancy, which is linked to irregular periods in the daughter, and possibly obesity and weight-related reproduction problems. A second pathway may involve reduced placental and foetal growth, which is linked to the more sev ere symptoms of PCOS in the daughter, usually resulting in an early clinical diagnosis of the syndrome. A foetus that has been affected by restricted growth is more likely to have problems with insulin metabolism in later life due to an underlying metabolic problem. In women this problem appears to be associated with PCOS, and is most evident where there is a constellation of symptoms of increasing severity. Hence, I suspect there are at least two pathways that can give rise to overlapping symptoms."

Dr Davies also mentioned that events occurred by even the grandmother could affect the bearing of the foetus. "To understand the growth of a child, we need to also understand the growth of the parents and possibly the grandparents. A good predictor of one's own birth weight is the birth weight of one's mother."

The study also shows development origins of PCS’s, "There are reproductive consequences of metabolic programming events that occur during foetal development; we may need to look further back up the generations and look at more factors than previously considered; and finally, adverse events for one generation may have reproductive implications for the next.

Related medicine news :

1. Developmental, neurologic problems common in extremely preterm infants
2. Pre Mature Babies Face the Risk Developmental Abnormalities
3. Developmental Delays in Infants Linked to DDT
4. MRI Scans in Premature Infants Can Predict Future Developmental Delays
5. Emotional Problems Common Among Children With Developmental Disabilities
6. Missing Molecule Has Important Role in a Developmental Brain Abnormality
7. Developmental And Behavioral Problems Can Plague Children With Asthma
8. Team Tracks Genetic Origins of Eye Cancer
9. Genetic Fingerprints Identify Brain Tumors Origins
10. Polycystic Ovarian Syndrome(PCOS) linked to Diabetes
11. Polycystic Ovary In Women May Raise Liver Disease
Post Your Comments:

(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of indulgence ... high can result in disappointment, perhaps even self-loathing. However, those who set the bar ... from reveals that behind the tendency to set low expectations is ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Comfort ... the American Cancer Society and the Road To Recovery® program to drive cancer patients ... seniors and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group ... Tournament held on June 20th at the Woodmont Country Club at 1201 Rockville ... an organization dedicated to helping service members that have been wounded in battle and ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... LAS VEGAS , June 26, 2016 ... movement to value-based care operating models within the health ... that enable greater financial efficiency , Deloitte offers ... address the key business issues impacting efficient cost optimization: ... alignment , These services facilitate better outcomes and ...
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)...   Bay Area Lyme Foundation , collaborating ... for Tick Borne Illness , Harvard Medical School ... Medicine, University of California, Berkeley, and the Veterans ... finalists of Lyme Innovation , the first ... scientists, clinicians, researchers, entrepreneurs, and investors from several ...
Breaking Medicine Technology: