Navigation Links
Developmental Origins of Polycystic Ovarian Syndrome

A recent study has revealed that the way a baby girl develops in a womb may adversely affect// chances of developing polycystic ovarian syndrome (PCO) as adults. Dr Michael Davies, senior researcher at the Research Center of Reproductive Health at the University of Adelaide, Australia headed this study. Dr Davies and his team studied a group of young women bon between 1973 and 1975. They decided to first contact the mothers from maternity hospital records and then interview the daughters. So far 544 women have been interviewed, all who are aged between 30 and 32. The study included a detailed report on the medical history as well as birth details. The details also included birth weight, placental weight, and so on. After a wide comparison Dr Davies said: "Symptoms of PCOS were relatively common. One in five women had more facial and/or body hair than normal, and one in four reported menstrual irregularity of greater than four days. Five per cent of women reported that they had an existing diagnosis of PCOS. We examined maternal weight in late pregnancy, birth weight and placental weight in relation to the symptoms of PCOS, or an existing or putative diagnosis of PCOS. Compared with their counterparts, young women without a diagnosis of PCOS but with irregular periods were heavier at birth, with larger placentas, and they tended to have mothers who were heavier in late pregnancy. In contrast, women with an existing diagnosis of PCOS tended to have birth weights that were, on average, 196g lighter than women without PCOS and smaller placentas”.

He further said, “Therefore, our data suggest that different developmental pathways are implicated in the overlapping symptoms of PCOS. One pathway may be mediated by high maternal weight in late pregnancy, which is linked to irregular periods in the daughter, and possibly obesity and weight-related reproduction problems. A second pathway may involve reduced placental and foetal growth, which is linked to the more sev ere symptoms of PCOS in the daughter, usually resulting in an early clinical diagnosis of the syndrome. A foetus that has been affected by restricted growth is more likely to have problems with insulin metabolism in later life due to an underlying metabolic problem. In women this problem appears to be associated with PCOS, and is most evident where there is a constellation of symptoms of increasing severity. Hence, I suspect there are at least two pathways that can give rise to overlapping symptoms."

Dr Davies also mentioned that events occurred by even the grandmother could affect the bearing of the foetus. "To understand the growth of a child, we need to also understand the growth of the parents and possibly the grandparents. A good predictor of one's own birth weight is the birth weight of one's mother."

The study also shows development origins of PCS’s, "There are reproductive consequences of metabolic programming events that occur during foetal development; we may need to look further back up the generations and look at more factors than previously considered; and finally, adverse events for one generation may have reproductive implications for the next.
'"/>




Related medicine news :

1. Developmental, neurologic problems common in extremely preterm infants
2. Pre Mature Babies Face the Risk Developmental Abnormalities
3. Developmental Delays in Infants Linked to DDT
4. MRI Scans in Premature Infants Can Predict Future Developmental Delays
5. Emotional Problems Common Among Children With Developmental Disabilities
6. Missing Molecule Has Important Role in a Developmental Brain Abnormality
7. Developmental And Behavioral Problems Can Plague Children With Asthma
8. Team Tracks Genetic Origins of Eye Cancer
9. Genetic Fingerprints Identify Brain Tumors Origins
10. Polycystic Ovarian Syndrome(PCOS) linked to Diabetes
11. Polycystic Ovary In Women May Raise Liver Disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2017)... ... 2017 , ... Journal of Oral Implantology – Tooth loss is ... dental health, including complications with speech, eating, and overcompensation of mouth due to the ... teeth. As the number of tooth replacements increase, it is imperative to design an ...
(Date:4/26/2017)... ... April 26, 2017 , ... Elisabete ... has been honored by Enterprising Women magazine as one of its 2017 Enterprising ... women business owners. Winners have demonstrated that they have fast-growth businesses, mentor or ...
(Date:4/26/2017)... ... 2017 , ... RawTrition now brings you BioEnergy which is a powder capsule ... , RawTrition is taking nutrients to the next level! The superfoods in ... raw form (unlike the synthetically made options that are on the market). , Founder ...
(Date:4/26/2017)... Gainesville, FL (PRWEB) , ... April 26, 2017 ... ... health and human performance, is proud to announce that it has received 510(k) ... cutting-edge technologies, the MyoCycle Home and the MyoCycle Pro. , Both devices are ...
(Date:4/25/2017)... , ... April 25, 2017 ... ... in Newport Beach, California, committed to raising awareness for Duchenne muscular dystrophy, ... from its randomized CAP-1002 (cardiosphere-derived cells) Phase I/II HOPE clinical trial in ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017  Novartis today announced the publication of ... and Blood Institute (NHLBI) of the National Institutes ... with treatment-naïve severe aplastic anemia (SAA) achieved complete ... at the initiation of and concurrently with standard ... sequential treatment groups, or cohorts. Cohort 3 added ...
(Date:4/18/2017)... -- Cardinal Health (NYSE: CAH ) today is ... share (EPS) guidance and providing a preliminary view on ... this morning,s announcement of the planned acquisition of Medtronic,s ... Cardinal Health now believes that fiscal 2017 ... bottom of its previous guidance range of $5.35 to ...
(Date:4/18/2017)... 18, 2017 Viverae ® , a leader ... integration of IBM ® Watson Campaign Automation, implementing ... communications for a personalized experience. Through digital engagement, the ... health in real time. The enhanced experience drives engagement ... members, wherever they are in their journey to health. ...
Breaking Medicine Technology: