Navigation Links
Development of kidney disease in adults with pre-diabetes

Diabetes is a major risk factor for the development of kidney disease and is the leading cause of end-stage renal disease in the U.S. However, whether pre-diabetes is associated with the development of kidney disease is unclear//.

The finding, that declines in kidney function are present early on among subjects with glucose intolerance could help direct therapeutic interventions to prevent the progression of kidney disease. Recently, researchers, writing in the October issue of Diabetes Care sought to examine the development of chronic kidney disease (CKD) in adults with pre-diabetes, metabolic syndrome, and diabetes in the general population, using the Framingham Heart Study to conduct this longitudinal study.

Subjects free of CKD were given an oral glucose tolerance test, and followed for an average of 7 years for development of CKD. Multivariable logistic regression models, adjusted for cardiovascular disease risk factors including age, sex, hypertension, smoking, BMI, total and HDL cholesterol levels, and prevalent myocardial infarction or congestive heart failure, were used to estimate the odds of patients developing kidney disease among glycemic categories.

Of 2,398 subjects, 63% were normoglycemic, 29% had impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), 3.4% were newly diabetic, and 4.6% had known diabetes. The risk of developing chronic kidney disease associated with pre-diabetes and newly diagnosed diabetes is largely accounted for by coexisting vascular disease risk factors. Similarly, vascular disease risk factors attenuated most of the relationship between insulin resistance and CKD. Gradation of risk for CKD appears to be linear across the spectrum of glycemic status, and known diabetes is a strong and independent risk factor for CKD.

Findings from this study suggest that concomitant vascular disease risk factors explain most of the increased odds of development of CKD seen among participants with IFG and newly diagnosed diabetes. Traditionally, diabetic nephropathy is thought to be a microvascular complication of diabetes, characterized by the classic Kimmelstiel-Wilson syndrome lesion. Data from this study suggest that CKD in the setting of pre-diabetes might be thought of as an additional complication of macrovascular atherosclerosis.

However, the researchers assert that clinical trials are warranted to determine whether vascular risk factor modification can slow the decline of kidney function among those with pre-diabetes.
'"/>




Related medicine news :

1. Developmental, neurologic problems common in extremely preterm infants
2. Development of AIDS vaccine -- Chiron Corp in talks with four Indian cos
3. Missing Protein In Cancer Development
4. Tomatoes Might Inhibit the Development Of Prostate Cancer
5. Pollution Found To Impair Lung Development
6. Treating Depression In Children Could Lead To Poor Bone Development
7. Developmental Origins of Polycystic Ovarian Syndrome
8. Sleep Not Critical For Early Brain Development Of Baby Dolphins
9. ‘Loud Noise’ Research may help in Development of Prosthetics for Eldery
10. Stop Watching TV: Toddler Development Affected
11. Vitamin Supplements During Pregnancy to Boost Fetal Development
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... ... provost of Liberty University, has officially announced the appointment of Peter A. Bell, ... College of Osteopathic Medicine (LUCOM), beginning April 10. Dr. Bell comes to ...
(Date:2/24/2017)... ... , ... The narrative in “ Signal 8: An Australian Paramedic’s Story ” ... paramedic experiences. Schanssema describes the tragedies he saw, as well as his struggles with ... Schanssema, initially unsure of the career path he wanted to take, found fulfillment in ...
(Date:2/24/2017)... ... ... Indiana Fiber Network (IFN) President and CEO Kelly C. Dyer recently announced ... the Chairman of the Management Committee when IFN was originally formed in 2002 where ... investor/owners and development of the business plan. He became the first paid employee ...
(Date:2/23/2017)... ... 23, 2017 , ... Thinksport, the most award-winning sunscreen on ... of Marin. For the second year in a row, cyclists will stay protected ... are thrilled to provide our safe, non-toxic sunscreen to over 2,000 cycling enthusiasts ...
(Date:2/23/2017)... Chapel Hill, NC (PRWEB) , ... February 23, 2017 , ... ... the Platinum Sponsor for ACPA’s 74th Annual Meeting. KLS is a longtime supporter ... in 2017 as an exhibitor and Platinum Sponsor," said Dr. Bob Havlik, 2017 ACPA ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Following receiving ... , s AMAR is a major milestone for the ... M w ound care market in ... BST for inclusion in the National Health Basket , ...   E-QURE Corp. (OTCQB: EQUR), a leader in medical devices ...
(Date:2/24/2017)... Feb 24, 2017 Research and Markets has announced ... 2016" report to their offering. ... The latest research Hemophilia Drugs Price Analysis and Strategies - ... The research answers the following questions: ... How are they positioned in the Global Hemophilia market? ...
(Date:2/24/2017)... Feb. 24, 2017 Medical information groups ... increase their self-service capabilities to manage inquiries from ... New research from consulting leader Best ... developed self-service website portals where HCPs can sign ... one of many findings to emerge from the ...
Breaking Medicine Technology: