Navigation Links
Development of kidney disease in adults with pre-diabetes

Diabetes is a major risk factor for the development of kidney disease and is the leading cause of end-stage renal disease in the U.S. However, whether pre-diabetes is associated with the development of kidney disease is unclear//.

The finding, that declines in kidney function are present early on among subjects with glucose intolerance could help direct therapeutic interventions to prevent the progression of kidney disease. Recently, researchers, writing in the October issue of Diabetes Care sought to examine the development of chronic kidney disease (CKD) in adults with pre-diabetes, metabolic syndrome, and diabetes in the general population, using the Framingham Heart Study to conduct this longitudinal study.

Subjects free of CKD were given an oral glucose tolerance test, and followed for an average of 7 years for development of CKD. Multivariable logistic regression models, adjusted for cardiovascular disease risk factors including age, sex, hypertension, smoking, BMI, total and HDL cholesterol levels, and prevalent myocardial infarction or congestive heart failure, were used to estimate the odds of patients developing kidney disease among glycemic categories.

Of 2,398 subjects, 63% were normoglycemic, 29% had impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), 3.4% were newly diabetic, and 4.6% had known diabetes. The risk of developing chronic kidney disease associated with pre-diabetes and newly diagnosed diabetes is largely accounted for by coexisting vascular disease risk factors. Similarly, vascular disease risk factors attenuated most of the relationship between insulin resistance and CKD. Gradation of risk for CKD appears to be linear across the spectrum of glycemic status, and known diabetes is a strong and independent risk factor for CKD.

Findings from this study suggest that concomitant vascular disease risk factors explain most of the increased odds of development of CKD seen among participants with IFG and newly diagnosed diabetes. Traditionally, diabetic nephropathy is thought to be a microvascular complication of diabetes, characterized by the classic Kimmelstiel-Wilson syndrome lesion. Data from this study suggest that CKD in the setting of pre-diabetes might be thought of as an additional complication of macrovascular atherosclerosis.

However, the researchers assert that clinical trials are warranted to determine whether vascular risk factor modification can slow the decline of kidney function among those with pre-diabetes.
'"/>




Related medicine news :

1. Developmental, neurologic problems common in extremely preterm infants
2. Development of AIDS vaccine -- Chiron Corp in talks with four Indian cos
3. Missing Protein In Cancer Development
4. Tomatoes Might Inhibit the Development Of Prostate Cancer
5. Pollution Found To Impair Lung Development
6. Treating Depression In Children Could Lead To Poor Bone Development
7. Developmental Origins of Polycystic Ovarian Syndrome
8. Sleep Not Critical For Early Brain Development Of Baby Dolphins
9. ‘Loud Noise’ Research may help in Development of Prosthetics for Eldery
10. Stop Watching TV: Toddler Development Affected
11. Vitamin Supplements During Pregnancy to Boost Fetal Development
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/29/2017)... ... 29, 2017 , ... Thomas Dickerson, Ed. D, FACHE, chief ... of the Board of Directors for the Radiology Business Management Association , ... Board President Jim Hamilton, MHA, CMM, FRBMA, an administrator and business manager for ...
(Date:5/28/2017)... ... , ... HYPERAMS, LLC announced it will perform the inventory liquidation ... Ohio. The sale began this week and the inventory is expected to sell quickly. ... and medical accessories, including blood pressure cuffs, stethoscopes, CPR masks, as well as blank ...
(Date:5/27/2017)... , ... May 26, 2017 , ... A May 8 ... visit a doctor for colds or respiratory issues that are not responsive to antibiotics ... pressure on doctors may be largely responsible for the problem both in Canada and ...
(Date:5/27/2017)... ... ... Most us are familiar with the sound of occasional popping joints that ... shows that certain people who experience consistent joint popping, grating and grinding are ... opportunity to treat patients before the problem becomes pronounced, potentially hedging off more severe ...
(Date:5/26/2017)... VA (PRWEB) , ... May 26, 2017 , ... ... pleased to announce a new educational seminar to focus on current legislative activity ... News(LEARN) seminar will begin at 1 p.m. Sunday, Sept. 10, and will continue ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... -- May is Stroke Awareness Month and Omron Healthcare is ... to prevent a stroke: monitor and manage your blood ... Prevention, undetected and uncontrolled hypertension is a leading risk ... in personal heart health technology, recently evolved its mission ... stroke and is advancing a national public education effort ...
(Date:5/4/2017)... and SAN DIEGO , May 4, ... (ACOG) 2017 Annual Clinical and Scientific Meeting— OBP Medical ... medical devices, today announced the launch of a new ... OfficeSPEC and ER-SPEC vaginal specula. Already ... extra-small and extra-large sizes makes OBP Medical,s line of ...
(Date:5/3/2017)...  Kalorama Information notes that transplant diagnostics is ... and this is projected to continue to 2021. ... or bone marrow transplants require histocompatibility between the ... this task. This according to a new report ... various PCR-based methodologies, Sanger sequencing and NGS used ...
Breaking Medicine Technology: