Navigation Links
Development of kidney disease in adults with pre-diabetes

Diabetes is a major risk factor for the development of kidney disease and is the leading cause of end-stage renal disease in the U.S. However, whether pre-diabetes is associated with the development of kidney disease is unclear//.

The finding, that declines in kidney function are present early on among subjects with glucose intolerance could help direct therapeutic interventions to prevent the progression of kidney disease. Recently, researchers, writing in the October issue of Diabetes Care sought to examine the development of chronic kidney disease (CKD) in adults with pre-diabetes, metabolic syndrome, and diabetes in the general population, using the Framingham Heart Study to conduct this longitudinal study.

Subjects free of CKD were given an oral glucose tolerance test, and followed for an average of 7 years for development of CKD. Multivariable logistic regression models, adjusted for cardiovascular disease risk factors including age, sex, hypertension, smoking, BMI, total and HDL cholesterol levels, and prevalent myocardial infarction or congestive heart failure, were used to estimate the odds of patients developing kidney disease among glycemic categories.

Of 2,398 subjects, 63% were normoglycemic, 29% had impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), 3.4% were newly diabetic, and 4.6% had known diabetes. The risk of developing chronic kidney disease associated with pre-diabetes and newly diagnosed diabetes is largely accounted for by coexisting vascular disease risk factors. Similarly, vascular disease risk factors attenuated most of the relationship between insulin resistance and CKD. Gradation of risk for CKD appears to be linear across the spectrum of glycemic status, and known diabetes is a strong and independent risk factor for CKD.

Findings from this study suggest that concomitant vascular disease risk factors explain most of the increased odds of development of CKD seen among participants with IFG and newly diagnosed diabetes. Traditionally, diabetic nephropathy is thought to be a microvascular complication of diabetes, characterized by the classic Kimmelstiel-Wilson syndrome lesion. Data from this study suggest that CKD in the setting of pre-diabetes might be thought of as an additional complication of macrovascular atherosclerosis.

However, the researchers assert that clinical trials are warranted to determine whether vascular risk factor modification can slow the decline of kidney function among those with pre-diabetes.
'"/>




Related medicine news :

1. Developmental, neurologic problems common in extremely preterm infants
2. Development of AIDS vaccine -- Chiron Corp in talks with four Indian cos
3. Missing Protein In Cancer Development
4. Tomatoes Might Inhibit the Development Of Prostate Cancer
5. Pollution Found To Impair Lung Development
6. Treating Depression In Children Could Lead To Poor Bone Development
7. Developmental Origins of Polycystic Ovarian Syndrome
8. Sleep Not Critical For Early Brain Development Of Baby Dolphins
9. ‘Loud Noise’ Research may help in Development of Prosthetics for Eldery
10. Stop Watching TV: Toddler Development Affected
11. Vitamin Supplements During Pregnancy to Boost Fetal Development
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... ... 2017 , ... Life of Purpose Treatment is proud to present “An Evening ... at 7:30 pm on May 10th at the University Auditorium. , This benefit concert, ... support the UF Collegiate Recovery Community (UFCRC). The concert will kick off the 5th ...
(Date:4/23/2017)... ... April 23, 2017 , ... ... services announced the achievement of Cisco Select certification and SMB specialization. Altura ... States. , In earning the Select Certification, Altura fulfilled the training ...
(Date:4/22/2017)... ... , ... The San Juan Capistrano summer camp team at the Boys and Girls ... summer camps to provide physical activities for all campers. To read the report, click ... With an increase in specialty camps that focus on what the report terms as “sitting ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... Chicago plastic ... the removal of osteoma. An osteoma is a benign bony lump located on the ... eye and can cause difficulties with sight and pain. Dr. Shah has discovered an ...
(Date:4/21/2017)... ... ... The adage “Show, don’t tell” applies perfectly to Green Builder Media’s Earth ... House demonstration project series. Manifesting the concept of right-sized living, the Flex House is ... affordably and abundantly without unduly taxing the resources of our beautiful planet. ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... April 20, 2017 Research and Markets ... Size, Market Share, Application Analysis, Regional Outlook, Growth Trends, Key ... to their offering. ... global pharmacogenomics market was valued at US$ 7,167.6 Mn in ... 2024, expanding at a CAGR of 5.6% from 2016 to ...
(Date:4/20/2017)... 20, 2017 Research and Markets has ... Manufacturing Services Market Analysis By Service (Manufacturing, Research), By Country, ... - 2025" report to their offering. ... The Latin American pharmaceutical contract manufacturing ... 2025 Low drug registration cost in Latin American ...
(Date:4/19/2017)... -- The Mobile X-Ray product segment is the most attractive ... forecast period Mobile X-Ray segment is the largest ... devices market, which is estimated to be valued at more ... of 7% over the forecast period. Mobile X-Ray segment is ... 100 Mn in 2017 over 2016. The segment,s revenue in ...
Breaking Medicine Technology: