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Dermatologists Provide Unique Evidence of Possible Cause of Rare Skin Condition

hers obtained 13 blocks of paraffin-embedded tissue samples from seven NSF/NFD patients exposed to gadolinium from the national NSF Registry of New Haven, Conn.1. An additional paraffin-embedded block containing tissue from a routine dermatopathology case served as the negative control. Researchers used a field emission scanning electron microscope equipped with electron dispersion spectroscopy to search the tissue for metals. They also were blinded as to which blocks of tissue were from NSF/NFD cases and which were from negative controls.

The study found that gadolinium was detected in four of 13 tissue specimens from patients with NSF/NFD who were exposed to the contrast agent. As expected, none of the negative controls tested positive for gadolinium.

“While clearly more research needs to be done, we are encouraged by our findings and hope that it provides an important first step in understanding the cause of this elusive disease,” said Dr. High. “Until more data becomes available, we urge patients with end-stage kidney disease and their health care providers to be aware of this potentially fatal association between gadolinium and NSF/NDF and make every effort to avoid any unnecessary, excessive dosage of this contrast agent.”

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