Navigation Links
Dermatologists Provide Unique Evidence of Possible Cause of Rare Skin Condition

While kidney failure is a serious condition that requires extensive medical intervention, a small subset of these patients are prone to developing another grave condition known as Nephrogenic Systemic Fibrosis or Nephrogenic Fibrosing Dermopathy (NSF/NFD). // First recognized as a disease in 1997, NSF/NFD causes discoloration and thickening or tightening of the skin, resulting in pain, muscle weakness and difficulty bending joints. In many cases, NSF/NFD results in scarring of internal organs that inhibit their ability to function properly, which can be fatal.

More than 215 cases of NSF/NFD have been documented in the last decade, but despite ongoing research, the cause of the disease is unknown. Now, results of a pilot study suggest that gadolinium-containing contrasting agents used for Magnetic Resonance Angiography (MRA) in patients with kidney failure may be the culprit.

In the report entitled, “Gadolinium is detectable within the tissue of patients with nephrogenic systemic fibrosis,” to be published in an upcoming issue of the Journal of the American Academy of Dermatology, dermatologist Whitney A. High, MD, MEng, Department of Dermatology at the University of Colorado, Denver, Colo., found that gadolinium was detected in tissue samples from four of seven patients with NSF/NFD.

“Although gadolinium-based contrast agents have a long history of safe and effective use in Magnetic Resonance Imaging (MRI), the dose of the agent administered to kidney failure patients undergoing MRA to examine blood vessels is up to three times higher than the amount used in a typical MRI test,” explained Dr. High. “Recent publications have suggested an association between exposure to gadolinium and the development of NSF/NFD, and our pilot study was designed to determine whether gadolinium was detected within the skin and soft tissue of patients with the disease who were exposed to this contrast agent.”

Dr. High and a team of researc hers obtained 13 blocks of paraffin-embedded tissue samples from seven NSF/NFD patients exposed to gadolinium from the national NSF Registry of New Haven, Conn.1. An additional paraffin-embedded block containing tissue from a routine dermatopathology case served as the negative control. Researchers used a field emission scanning electron microscope equipped with electron dispersion spectroscopy to search the tissue for metals. They also were blinded as to which blocks of tissue were from NSF/NFD cases and which were from negative controls.

The study found that gadolinium was detected in four of 13 tissue specimens from patients with NSF/NFD who were exposed to the contrast agent. As expected, none of the negative controls tested positive for gadolinium.

“While clearly more research needs to be done, we are encouraged by our findings and hope that it provides an important first step in understanding the cause of this elusive disease,” said Dr. High. “Until more data becomes available, we urge patients with end-stage kidney disease and their health care providers to be aware of this potentially fatal association between gadolinium and NSF/NDF and make every effort to avoid any unnecessary, excessive dosage of this contrast agent.”

Source-Newswie
SRM
'"/>




Related medicine news :

1. Chances of Survival for Melanoma is High When Detected by Dermatologists
2. Drug Spironolactone Provides Renal And Cardioprotection In Diabetic Patients
3. Neurobiology Provides Answers To Block Memory-Related Drug Cravings
4. Reliance Infocomm Tied With Apollo To Provide Telemedicine Services
5. Leeches Provide Clues Regarding The Prevention Of Heart Disease
6. Apollo Hospitals Short-listed to Provide Diagnostics in the UK
7. Reindeer Provide Valuable Insights Into Sleep Disorders
8. London Hospital Provides Specialized Care For Pregnant Women
9. CNIC To Provide Funds To Mount Sinai School
10. Clean Blades To Be Provided To Self-Harmers
11. Breastfeeding Provides Added Protection To Babies
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2016)... ... May 24, 2016 , ... WaterAid launched the #perioddrama campaign to mark Menstrual ... 1 billion women around the world who do not have access to a toilet, even ... US about their dread of #perioddrama. The (sometimes hilarious) results help shine a light on ...
(Date:5/24/2016)... ... May 24, 2016 , ... Local chiropractor Dr. Jason ... 21, 2016. Dr. Gerard, who holds a Doctorate of Chiropractic and Bachelors of ... health and wellness in Third World countries where resources are limited. , ChiroMission ...
(Date:5/24/2016)... ... May 24, 2016 , ... The Dream Builders Project, ... and other necessities to Eunime Orphanage in Tijuana, Mexico on Saturday, May 21st. The ... at Peter Piper Pizza. , More than 15 volunteers traveled from Los Angeles ...
(Date:5/24/2016)... ... 2016 , ... The old expression “a pain in the neck” takes on ... misunderstood, whiplash should be swiftly diagnosed and treated if those affected want to quickly ... Spine Center . , So named because of the whip-like, rapid back-and-forth neck ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... After graduating ... He spent the next decade in hospitals, on medication, living on Social Security disability ... at the Illness and How I Beat It!” (published by Balboa Press), Alexander shares ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... 2016 Global Paclitaxel Market 2016 ... 12 companies and the Paclitaxel analysis in this study ... industry and its players. This is the ... details the current state of the industry while providing ... applications and industry chain structure. The Paclitaxel market analysis ...
(Date:5/23/2016)... , May 23, 2016 ... Size, Share, Development, Growth and Demand Forecast to ... and Other), by Application (Drug Discovery and Development, ... Users (Pharmaceuticals, Life Science and Biotechnology, Academic and ... Market Research, the global mass spectrometry market ...
(Date:5/23/2016)... 2016 Non-invasive diagnostic test realizes ... diseases; ,Technology to be presented at Yissum’s booth, at ... Development Company of the Hebrew University of Jerusalem ... with Aurum Ventures MKI, the technology investment arm of ... diagnostic approach for early detection of multiple diseases by ...
Breaking Medicine Technology: