Navigation Links
Dermatologists Provide Unique Evidence of Possible Cause of Rare Skin Condition

While kidney failure is a serious condition that requires extensive medical intervention, a small subset of these patients are prone to developing another grave condition known as Nephrogenic Systemic Fibrosis or Nephrogenic Fibrosing Dermopathy (NSF/NFD). // First recognized as a disease in 1997, NSF/NFD causes discoloration and thickening or tightening of the skin, resulting in pain, muscle weakness and difficulty bending joints. In many cases, NSF/NFD results in scarring of internal organs that inhibit their ability to function properly, which can be fatal.

More than 215 cases of NSF/NFD have been documented in the last decade, but despite ongoing research, the cause of the disease is unknown. Now, results of a pilot study suggest that gadolinium-containing contrasting agents used for Magnetic Resonance Angiography (MRA) in patients with kidney failure may be the culprit.

In the report entitled, “Gadolinium is detectable within the tissue of patients with nephrogenic systemic fibrosis,” to be published in an upcoming issue of the Journal of the American Academy of Dermatology, dermatologist Whitney A. High, MD, MEng, Department of Dermatology at the University of Colorado, Denver, Colo., found that gadolinium was detected in tissue samples from four of seven patients with NSF/NFD.

“Although gadolinium-based contrast agents have a long history of safe and effective use in Magnetic Resonance Imaging (MRI), the dose of the agent administered to kidney failure patients undergoing MRA to examine blood vessels is up to three times higher than the amount used in a typical MRI test,” explained Dr. High. “Recent publications have suggested an association between exposure to gadolinium and the development of NSF/NFD, and our pilot study was designed to determine whether gadolinium was detected within the skin and soft tissue of patients with the disease who were exposed to this contrast agent.”

Dr. High and a team of researc hers obtained 13 blocks of paraffin-embedded tissue samples from seven NSF/NFD patients exposed to gadolinium from the national NSF Registry of New Haven, Conn.1. An additional paraffin-embedded block containing tissue from a routine dermatopathology case served as the negative control. Researchers used a field emission scanning electron microscope equipped with electron dispersion spectroscopy to search the tissue for metals. They also were blinded as to which blocks of tissue were from NSF/NFD cases and which were from negative controls.

The study found that gadolinium was detected in four of 13 tissue specimens from patients with NSF/NFD who were exposed to the contrast agent. As expected, none of the negative controls tested positive for gadolinium.

“While clearly more research needs to be done, we are encouraged by our findings and hope that it provides an important first step in understanding the cause of this elusive disease,” said Dr. High. “Until more data becomes available, we urge patients with end-stage kidney disease and their health care providers to be aware of this potentially fatal association between gadolinium and NSF/NDF and make every effort to avoid any unnecessary, excessive dosage of this contrast agent.”


Related medicine news :

1. Chances of Survival for Melanoma is High When Detected by Dermatologists
2. Drug Spironolactone Provides Renal And Cardioprotection In Diabetic Patients
3. Neurobiology Provides Answers To Block Memory-Related Drug Cravings
4. Reliance Infocomm Tied With Apollo To Provide Telemedicine Services
5. Leeches Provide Clues Regarding The Prevention Of Heart Disease
6. Apollo Hospitals Short-listed to Provide Diagnostics in the UK
7. Reindeer Provide Valuable Insights Into Sleep Disorders
8. London Hospital Provides Specialized Care For Pregnant Women
9. CNIC To Provide Funds To Mount Sinai School
10. Clean Blades To Be Provided To Self-Harmers
11. Breastfeeding Provides Added Protection To Babies
Post Your Comments:

(Date:11/27/2015)... ... 2015 , ... Consistent with the Radiology Business Management ... Radiology Marketing Programs meeting will showcase some of the best 2015 radiology ... Palace in Las Vegas with a pre-conference session on a collaborative approach for ...
(Date:11/27/2015)... ... November 27, 2015 , ... The moment you stop ... not only fulfilling the needs of advisers and clients but going above and ... providing top-tier customer service. However, there's always room for improvement, which is why ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men and women ... healthcare organizations in the country. They have overseen financial turnarounds, shown commitment to ... the healthcare industry as a whole through their advocacy and professional efforts. , ...
(Date:11/27/2015)... ... November 27, 2015 , ... Indosoft Inc., developer and ... of Asterisk 11 LTS (Long Term Support) into its Q-Suite 5.10 product line. ... 5.10 up-to-date with a version of Asterisk that will receive not only security ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... system for diagnostic imaging in the Waterloo region. Using the Ocean Platform, family ... tests directly from their electronic medical record (EMR) without the need for redundant ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)...  Linden Care, LLC, a retail specialty pharmacy focused ... suffering from chronic pain, said today that it is ... (TRO) enjoining Express Scripts from unilaterally terminating the Pharmacy ... --> --> The company said that ... --> --> In ...
(Date:11/25/2015)... USA , Inc., a leader in ... accuracy of its blood glucose meter systems. Last week ... Cardiovascular Disease in Los Angeles , ... 01 meter and the Assure ® Prism multi-user ... measure glucose levels in blood is essential for people ...
(Date:11/25/2015)... DUBLIN , Nov. 25, 2015 Allergan plc ... an agreement with the New York State ... 2 of the Sherman Act, and other statutes with the ... in February 2014, to cease marketing and selling the now ... of settlement, Allergan admits no liability, has released its counterclaims ...
Breaking Medicine Technology: