Navigation Links
Dermaseptins: Potent vaginal contraceptives

Safe and effective vaginal contraceptives are urgently needed. Ideally, such products should have antimicrobial and antiviral properties; as such, they could also play a role in the reduction of sexually// transmitted diseases (STDs), particularly the human immunodeficiency virus (HIV).

Most of the spermicidal products being marketed presently contain a detergent as an active ingredient, which do not provide any protection against STDs and that their effect in preventing HIV transmission remains controversial. Also, the repeated use of a surfactant as a vaginal contraceptive/microbicide has been associated with an increased risk of vaginal or cervical infection and irritation or ulceration. Because of this, it is important to identify and evaluate a new generation of contraceptive antimicrobial agents can be used vaginally in effective doses without causing overt vaginal irritation or other toxicity.

Antimicrobial peptides are produced by both prokaryotic and eukaryotic cells and have been the subject of many studies in recent years because of their involvement in host defense mechanisms and their potential use as therapeutic agents. These antimicrobial peptides include dermaseptins (DSs), a family of five structurally and functionally related peptides that were originally isolated from the skin of a tree-dwelling South American frog (Phyllomedusa sauvagei).

Recently, researchers from the Laboratory of Biochemistry, Faculty of Medicine, Sousse, Tunisia, thought that it would be interesting to develop a vaginal contraceptive with these compounds that have many biologic properties.

In their study, to be published in Contraception (available online 26 August 2005), the researchers set out to determine the effectiveness of two synthetic antimicrobial peptides, dermaseptin (DS1 and DS4) for inhibiting sperm motility. In addition, the mechanism of their spermicidal action was investigated and possible synergistic spermicidal effects exerted by EDTA were evaluated.

For the study, twenty samples of fresh semen were obtained from patients aged between 23 and 35 years. The data showed that sperm motility was inhibited with various concentrations of DS at different intervals ranging from 2 to 240 min. The action of DSs on sperm motility was observed to be dose dependent. Supplementation with pentoxifylline and that with calcium are known to enhance the motility of sperm but they did not prevent the spermicidal action of DSs.

This study indicates that DS is an effective agent to kill sperm. In view of this fact, it is suggested that DS4 has antibacterial, antiviral, antifungal and potentially spermicidal activities and could be a potent vaginal contraceptive.

However, the authors state that further studies are necessary to elucidate the mode of DS action, and suggest that considering the available information about contraceptive efficacy, the different biologic properties of these peptides should be studied as new candidates for human use as a barrier contraceptive agent with additional protection against STDs.
'"/>




Related medicine news :

1. Potential New Cancer Gene Identified
2. Lack of Smell And Its Potential Risks
3. New Blood Thinner Pill - First Potential Alternative to Warfarin in 50 years
4. The Potential Of Cadaver Transplantation Programme In India
5. Another Potential Of Stem Cells Discovered: Used For Growing Cartilage
6. Yoga Guru Ramdev Invited to Tap Ayurveda Potential by Jharkhand Govt
7. A Protein In Yoghurt Has The Potential To Fight E. coli
8. Gold Therapy- A Potential Treatment For Autoimmune Diseases
9. Whirlpool Bath Tubs Contain Potentially Lethal Bacterial Strains
10. A Potent Sedative Kills Great-grandfather
11. Potential Benefits Of New Nanotechnology
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ... alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with ... for the primary prevention of cardiovascular diseases during the 15th Annual Women’s ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The Visiting ... Day Market. Featuring a collection of specialty vendors and unique items from across the ... and quality-focused health and wellness services offered by the VNA. The boutique will ...
(Date:10/13/2017)... ... 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at ... towards children of all ages; it is a non-competitive, non-timed event, which is all ...
(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  Hill-Rom Holdings, Inc. ... Aspen Surgical facility in Las Piedras, Puerto ... scalpels and blades. ... that the facility sustained minor structural damage, temporary loss ... Maria. Repairs have been completed, manufacturing operations have resumed, ...
(Date:10/4/2017)... SEOUL, South Korea , Oct. 4, 2017 /PRNewswire/ ... launched its next-generation CPR training aide "cprCUBE" on Kickstarter. ... of chest compression during cardiac arrests with better efficiency ... patient-mannequins. It also offers real-time feedback on efficacy of ... The crowdfunding campaign has a goal to raise ...
(Date:10/2/2017)... Fla. , Oct. 2, 2017  AllianceRx Walgreens ... company formed by Walgreens and pharmacy benefit manager Prime ... its new brand, which included the unveiling of new ... , as well as at a few other ... the new brand to patients, some of whom will ...
Breaking Medicine Technology: