Navigation Links
Dementia and Down Syndrome

Researchers comparing brain changes leading to dementia in people with Down syndrome with those seen in Alzheimer's disease report initial results in a recent issue of Neurology. //

Studies indicate 50 percent to 75 percent of all people with Down syndrome will eventually develop signs of dementia, and autopsies show nearly all people with Down syndrome show signs of the brain tangles and plaques commonly associated with Alzheimer's disease -- even when the individual in question did not appear to suffer from dementia while alive. Little research exists to explain the association between Down syndrome and Alzheimer's.

Investigators from the University of California, Irvine, are in the midst of a long-term study to gauge changes in the brains of Down syndrome patients and compare them to changes seen in Alzheimer's patients. The study involves 17 people with Down syndrome who currently show no signs of dementia, 10 people with moderate Alzheimer's, and 24 healthy control subjects. In the initial phase, all underwent positron emission tomography scans to measure glucose metabolic rates in the brain while performing a task involving mental abilities. GMR is known to play a role in dementia.

Results showed lower GMR levels in Down syndrome and Alzheimer's patients when compared to the healthy controls in the posterior cingulate, an area of the brain known to exhibit decreased function in early Alzheimer's. However, GMR was lower in Alzheimer's patients and higher in Down syndrome patients when compared to controls in another brain area related to Alzheimer's -- the temporal cortex.

The investigators plan to continue to follow these patients to see if GMR in the temporal cortex of the Down syndrome patients begins to mimic that seen in the Alzheimer's patients as clinical signs of dementia develop. Ultimately, they hope to find a very early stage at which GMR occurs in the brains of Alzheimer's patients and a way to scan for this occurrence, leading to better treatment for the condition.


'"/>




Related medicine news :

1. Dementia - a global problem
2. Dementia linked to HIV
3. Stroke and Dementia - a ghastly association
4. Change in walking might indicate Dementia
5. Hormone Therapy Linked to Dementia
6. Protection from Dementia
7. Drug Effective for Vascular Dementia
8. Lifestyle changes Can Delay the Onset Of Dementia
9. Lifestyle changes Can Delay the Onset Of Dementia
10. Lifestyle changes Can Delay the Onset Of Dementia
11. Could Midlife Alcohol Drinking Lead To Dementia ?
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/17/2017)... ... January 17, 2017 , ... Lynx ... among the top US security companies for consecutive years, today announced the appointment ... a year-long independent board nomination process to a close and positions Lynx for ...
(Date:1/17/2017)... ... January 17, 2017 , ... Twelve ... State University’s Athletic Training Education program forged a relationship built upon the foundation ... Program, which is consists of both student members and certified members of the ...
(Date:1/16/2017)... ... , ... California Southern University has named Dr. Steven Beazley University President. ... as a core faculty member, teaching master’s and doctoral courses in the university’s School ... University, where he earned his Doctor of Psychology degree in 1998. Dr. Beazley also ...
(Date:1/16/2017)... ... January 16, 2017 , ... With the Grand Opening Event planned for ... use by sports teams and the general public. Built in five months by Centerpoint, ... be converted into basketball or pickleball courts. The space is also suitable for indoor ...
(Date:1/16/2017)... New York (PRWEB) , ... January 16, 2017 ... ... SightMD today announced the addition of Victor Giamos, MD to their ... of SightMD and Managing Partner at North Shore Eye Care, a division of ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... , Jan. 17, 2017   Tocagen Inc ., a clinical-stage, ... Ph.D., executive vice president, research and pharmaceutical development at Tocagen, will ... to be held Jan. 17-20 in Miami . ... ... oxymoron: exciting manufacturing for replicating viruses - what to do when ...
(Date:1/17/2017)... ROCKLAND, Mass. , Jan. 17, 2017  EMD ... Germany , in the U.S. and ... R. Smith has joined the company as Senior ... In this role, Mr. Smith will oversee the Fertility ... Fertility Technologies division, which launched its first product last ...
(Date:1/17/2017)... LONDON , January 17, 2017 ... poised to potentially earn millions in revenue with the ... prevent massive numbers of strokes with a simple test ... Biotech Companies with latest developments in the markets today ... PLC (NYSE: AZN ), Cancer Genetics, Inc. ...
Breaking Medicine Technology: