Navigation Links
Dementia and Down Syndrome

Researchers comparing brain changes leading to dementia in people with Down syndrome with those seen in Alzheimer's disease report initial results in a recent issue of Neurology. //

Studies indicate 50 percent to 75 percent of all people with Down syndrome will eventually develop signs of dementia, and autopsies show nearly all people with Down syndrome show signs of the brain tangles and plaques commonly associated with Alzheimer's disease -- even when the individual in question did not appear to suffer from dementia while alive. Little research exists to explain the association between Down syndrome and Alzheimer's.

Investigators from the University of California, Irvine, are in the midst of a long-term study to gauge changes in the brains of Down syndrome patients and compare them to changes seen in Alzheimer's patients. The study involves 17 people with Down syndrome who currently show no signs of dementia, 10 people with moderate Alzheimer's, and 24 healthy control subjects. In the initial phase, all underwent positron emission tomography scans to measure glucose metabolic rates in the brain while performing a task involving mental abilities. GMR is known to play a role in dementia.

Results showed lower GMR levels in Down syndrome and Alzheimer's patients when compared to the healthy controls in the posterior cingulate, an area of the brain known to exhibit decreased function in early Alzheimer's. However, GMR was lower in Alzheimer's patients and higher in Down syndrome patients when compared to controls in another brain area related to Alzheimer's -- the temporal cortex.

The investigators plan to continue to follow these patients to see if GMR in the temporal cortex of the Down syndrome patients begins to mimic that seen in the Alzheimer's patients as clinical signs of dementia develop. Ultimately, they hope to find a very early stage at which GMR occurs in the brains of Alzheimer's patients and a way to scan for this occurrence, leading to better treatment for the condition.


'"/>




Related medicine news :

1. Dementia - a global problem
2. Dementia linked to HIV
3. Stroke and Dementia - a ghastly association
4. Change in walking might indicate Dementia
5. Hormone Therapy Linked to Dementia
6. Protection from Dementia
7. Drug Effective for Vascular Dementia
8. Lifestyle changes Can Delay the Onset Of Dementia
9. Lifestyle changes Can Delay the Onset Of Dementia
10. Lifestyle changes Can Delay the Onset Of Dementia
11. Could Midlife Alcohol Drinking Lead To Dementia ?
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2017)... ... , ... Harbour , a DAO (decentralized autonomous organization) that harnesses the ... their technical specifications . , 2017 has seen an explosion of token launches ... which offerings will garner the greatest ROI. Dean Eigenmann, Co-founder and CEO of Harbour, ...
(Date:6/27/2017)... , ... June 27, 2017 , ... A January 18th ... projected to reach a staggering $6.81 billion by the year 2024 according to a ... a faster rate than those made from titanium. Los Angeles area clinic Beverly Hills ...
(Date:6/27/2017)... ... June 27, 2017 , ... Drs. Gregory Toback and ... in Mystic, CT. Covering the process and maintenance strategies of gum grafting and ... periodontal procedures. Drs. Toback and Urbanski practice as experienced periodontists in ...
(Date:6/27/2017)... Los Angeles, CA (PRWEB) , ... June 27, 2017 , ... ... on what crooked bites can indicate about early life experiences. What happens to a ... study reveals that stresses after birth can also take a toll on a baby’s ...
(Date:6/26/2017)... ... June 26, 2017 , ... The Centers for Advanced Orthopaedics ... of Richard Robinson as chief operating officer (COO). In this role, Robinson brings ... track record of simplifying business processes and developing growth strategies to increase market ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... , June 9, 2017 AirXpanders, Inc. (ASX: ... on the design, manufacture, sale and distribution of the ... the progress of its commercial roll-out in ... in more than one hundred (100) medical institutions and ... AeroForm offers a needle-free alternative for women who choose ...
(Date:6/7/2017)... , June 7, 2017 Endo International ... June 7, 2017, the Hon. Joseph R. Goodwin ... of West Virginia , entered a ... Inc. Pelvic Repair System Products Liability Litigation (the "MDL") ... MDL cases to provide expert disclosures on specific causation ...
(Date:6/3/2017)... 3, 2017  Eli Lilly and Company (NYSE: ... from the Phase 3 MONARCH 2 study showed ... inhibitor, in combination with fulvestrant, significantly improved progression-free ... in women with hormone-receptor-positive (HR+), human epidermal growth ... have relapsed or progressed after endocrine therapy (median ...
Breaking Medicine Technology: