Navigation Links
Dementia and Down Syndrome

Researchers comparing brain changes leading to dementia in people with Down syndrome with those seen in Alzheimer's disease report initial results in a recent issue of Neurology. //

Studies indicate 50 percent to 75 percent of all people with Down syndrome will eventually develop signs of dementia, and autopsies show nearly all people with Down syndrome show signs of the brain tangles and plaques commonly associated with Alzheimer's disease -- even when the individual in question did not appear to suffer from dementia while alive. Little research exists to explain the association between Down syndrome and Alzheimer's.

Investigators from the University of California, Irvine, are in the midst of a long-term study to gauge changes in the brains of Down syndrome patients and compare them to changes seen in Alzheimer's patients. The study involves 17 people with Down syndrome who currently show no signs of dementia, 10 people with moderate Alzheimer's, and 24 healthy control subjects. In the initial phase, all underwent positron emission tomography scans to measure glucose metabolic rates in the brain while performing a task involving mental abilities. GMR is known to play a role in dementia.

Results showed lower GMR levels in Down syndrome and Alzheimer's patients when compared to the healthy controls in the posterior cingulate, an area of the brain known to exhibit decreased function in early Alzheimer's. However, GMR was lower in Alzheimer's patients and higher in Down syndrome patients when compared to controls in another brain area related to Alzheimer's -- the temporal cortex.

The investigators plan to continue to follow these patients to see if GMR in the temporal cortex of the Down syndrome patients begins to mimic that seen in the Alzheimer's patients as clinical signs of dementia develop. Ultimately, they hope to find a very early stage at which GMR occurs in the brains of Alzheimer's patients and a way to scan for this occurrence, leading to better treatment for the condition.


'"/>




Related medicine news :

1. Dementia - a global problem
2. Dementia linked to HIV
3. Stroke and Dementia - a ghastly association
4. Change in walking might indicate Dementia
5. Hormone Therapy Linked to Dementia
6. Protection from Dementia
7. Drug Effective for Vascular Dementia
8. Lifestyle changes Can Delay the Onset Of Dementia
9. Lifestyle changes Can Delay the Onset Of Dementia
10. Lifestyle changes Can Delay the Onset Of Dementia
11. Could Midlife Alcohol Drinking Lead To Dementia ?
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2016)... ... 12, 2016 , ... The aging population and longer life ... care. With that, says Patrick Loughney, president of Longtree & Associates, LLC ... term care environments. His company, which offers prep courses and workshops in long ...
(Date:2/12/2016)... ... , ... Planet Future is a Final Cut Pro X themed ... showcasing pictures, videos as well as text in an exciting cartoon environment. Planet Future ... a beautiful frame overlay. Pixel Film Studios makes editing easy; simply insert media into ...
(Date:2/11/2016)... ... February 12, 2016 , ... Fitbody Personal Training offers ... fun and exciting way to get fit and healthy. Located in Phoenixville, PA, the ... for a class designed for horseback riders who want to lose weight and tone ...
(Date:2/11/2016)... ... February 11, 2016 , ... SPH Analytics announced ... analytics leader’s population health solutions, MDinsight® and IndiGO®, for its primary care clinicians. ... system. Details of the contract were not disclosed. , As the healthcare market ...
(Date:2/11/2016)... ... February 11, 2016 , ... Dr. Sadati’s recent feature in ... Along with performing procedures, the magazine also highlights that Dr. Sadati has pioneered ... of the most common procedures he performs is his natural facelift. “As people ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Calif. , Feb. 11, 2016  Walgreens has ... across 39 states and Washington, D.C. ... a move that was commended by shareholder advocacy organization As ... at As You Sow. "Many people hold on to unneeded ... which can have tragic consequences." --> Conrad ...
(Date:2/11/2016)... 2016 Potrero Medical, Inc., the developer of the ... appointment of George M. Rapier, III , MD, to ... , WellMed is one of the nation,s largest physician ... members in Texas and ... his own internal medicine practice, he has been instrumental to ...
(Date:2/11/2016)... N.C. , Feb. 11, 2016 ... leading provider of custom manufacturing and development services ... expanded sterile fill-finish capabilities and capacity in its ... growth in demand has driven several recent investments. ... 2001 it had one filling line with small-scale ...
Breaking Medicine Technology: