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DelSite Working Toward Solving Delivery of Influenza Vaccine in Pandemic Situations

el from China to the U.S. With today's faster transportation systems allowing 1.2 million people to enter the U.S. each day, it is anticipated the virus would spread much faster. For containment of disease, a massive and expeditious vaccination program, along with other measures, would have to be initiated as quickly as possible.

According to the same expert, about 10 million doses per week for 25 weeks would have to be delivered in order to protect the U.S. population during a full pandemic. Current cold chain distribution systems may not be able to respond, but a nasal powder vaccine that can be shipped at room temperature and be self-administered may be a solution. DelSite's nasal powder technology meets these criteria and could add additional value by providing immunological protection to recipients at the site where viruses normally enter the body: the respiratory tract.

3. An effective adjuvant to make the vaccine more powerful. One proposed approach was to have the vaccine in one vial and the adjuvant in another vial, and then combine the vaccine with the adjuvant at the site of vaccination. It was suggested that this approach would allow or better stockpiling of the adjuvant, which would have a longer shelf life than the vaccine antigen. However, this system may double distribution logistics and therefore may be less feasible. DelSite has data indicating that the GelVac(TM) powder formulation could be shipped as a powder and reconstituted with sterile water just prior to injection. GelVac(TM) powder formulation also has a strong immuno-enhancing or adjuvant-like effect when it is injected after reconstitution through sustained release of the injected antigen. This effect could provide protection for more people at lower doses without the need for a separate adjuvant.

4. A way to reduce the number of months required to produce necessary antigen, if different from stockpile. Currently, chicken eggs are used in th
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