Navigation Links
Defect In Cardiac Cells Lead To Heart Failures

Defect in the molecular level in the cells of the heart may be responsible for causing heart failures.

The findings, by researchers at The Ohio State University Dorothy M. Davis Heart and Lung Research Institute, // show that specialized proteins called ryanodine receptors (RyRs) malfunction in the failing heart. The RyRs form channels that become leaky, leading to calcium imbalances that prevent the heart from contracting effectively and relaxing adequately. The condition worsens until the heart can no longer work as a pump. The root causes of heart failure are not known.

Researchers had found some drastic changes in the way muscle cells in the failing heart handle calcium. Discovery of this mechanism suggests at least one potential target for treating the causes of this disease in a rational manner.

Currently, the only way to correct heart failure is by heart transplantation. Those with the condition are at six to nine times greater risk of experiencing sudden cardiac death than someone in the general population. From 1992 to 2002, deaths from heart failure rose 35 percent and the incidence is expected to keep rising.

Calcium plays a fundamental role in muscle contraction, particularly in heart muscle. A heart contraction begins when the heart’s pacemaker sends an electrical signal to heart-muscle cells. The electrical signal triggers the release of calcium from a large storage site within each muscle cell. The released calcium activates the muscle cell’s contractile machinery, which causes the cell, and the heart as a whole, to contract.

This calcium storage site is known as the sarcoplasmic reticulum (SR), and it resembles a convoluted, flattened sack within the cell. The delicate, membrane-bound walls of the SR are penetrated with thousands of RyR channels. These serve as gatekeepers that allow calcium to flood into the cell to initiate contraction.

The amount of calcium stored in the SR dete rmines the strength of the heartbeat and how much blood the heart ejects when it contracts. At the end of a contraction, the channels close tightly. Molecular pumps, also located in the walls of the SR, then suck the released calcium back into the SR to prepare for the next contraction.

Source: Newswise

Related medicine news :

1. IVF technique May Increase The Risk Of Birth Defects
2. Epilepsy Drugs Can Enhance Risk of Birth Defects
3. Defective heart valve causes problems
4. Fortifying Foods Found To Reduce Birth Defects
5. Making Fortification Mandatory In Order To Reduce Birth Defects
6. Birth Defects Caused By Drugs Used For Epilepsy
7. Birth Defects Caused By Acne Medication Can Be Minimized By Voluntary Pregnancy Prevention
8. Addition Of Folic Acid In Flour Proposed To Arrest Birth Defects In The UK
9. Risk Of Birth Defects Slightly Increased Due To IVF
10. Risk Of Birth Defects Increased Due To Anti-Depressant Medication
11. Down’s Syndrome Is The Leading Birth Defect In the U
Post Your Comments:

(Date:10/13/2015)... ... October 13, 2015 , ... ... have developed valuable new strategies for enrolling and serving insurance consumers who do ... obtain health insurance and pay monthly premiums. In “Health Plan Engagement Strategies: The ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... ... smoke-free communities, and the Florida Apartment Association (FAA) has partnered with the Florida ... communities meet the demand. , The FAA Smoke-Free Multifamily Housing Program launched ...
(Date:10/13/2015)... ... 13, 2015 , ... Just under three months ago, eMarketing Concepts ... promotion – effectively offering all of their services for just a buck in the ... flooded with phone calls from interested buyers. As a genuine one-stop-shop for internet marketing, ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... a new PDF automation tool to batch conversions of CAD drawings, plans, ... 100% document fidelity. , CADConverter eliminates the complexity requirement of specialized applications to ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... The Bill ... in San Diego, also offering expert reconstruction and flood remediation services. Family-owned and operated ... They have been named the Best San Diego plumber two years in a row ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... Va. , Oct. 12, 2015  Today, Divurgent is ... of Advisory Services. As a former CIO, Paul brings 15 ... not just understand or sympathize with today,s CIOs, he is ... the same challenges Paul has faced, and his new role ... in ensuring technology efficiencies across an organization. ...
(Date:10/12/2015)... DENVER , Oct. 12, 2015 Beginning ... ICD-10 Codes. Therapy Partner, the fastest growing practice management ... automated technology that easily converts all patient diagnostic codes ... --> --> ... Brief for all mental health practitioners to easily understand ...
(Date:10/12/2015)... INDIANAPOLIS , Oct. 12, 2015 Eli ... ACCELERATE study,s academic leadership have accepted the recommendation of ... 3 trial of the investigational medicine evacetrapib, due to ... the treatment of high-risk atherosclerotic cardiovascular disease and will ... --> --> The independent data ...
Breaking Medicine Technology: