( ad a 30% weight loss--the equivalent of...)Decrease of 'Hunger Hormone' after Obesity Surgery,Health

ad a 30% weight loss--the equivalent of 34 pounds for a 200-pound woman--had a 24% increase in ghrelin levels compared with their pre-diet levels. In contrast, people who underwent surgery had ghrelin levels 80% lower than normal-weight people, even though they had a 30% weight loss.

Hormone levels also rose sharply before meals and declined after eating among obese dieters and normal-weight adults but remained steady in individuals who had surgery. Dr. Jeffrey S. Flier from Medical Center in Boston, Massachusetts notes that research into whether these drugs will mimic the effects of gastric bypass surgery or result in unexpected medical consequences is needed.

It is also unclear how gastric bypass surgery leads to a reduction in ghrelin levels. Nonetheless, the findings indicate that the hormone contributes to hunger and plays a key role in the long-term regulation of body weight, the study authors note. They concluded that their finding showed significant reduction of ghrelin levels after gastric bypass and thereby suggests that suppression of ghrelin can be studied as a potential mechanism by which this procedure causes weight loss.


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