Navigation Links
Decoding the Fungi Genome Will Save Millions of Lives.

Researchers from the University of Manchester, US, have decoded the genetic code of the Fungus belonging to the family Aspergillus. This has been the major cause of death due to secondary infection in patients suffering from // leukemia and those who have undergone marrow transplants.

This research is primarily focused on the idea of saving lives of millions of people by developing new drugs which could arrest these fungal infections. Three different species were studied; they are Aspergillus fumigatus, Aspergillus nidulans and Aspergillus oryzae. It was very surprising to know that they were very different genetically.

This was established when their genome was completely mapped and published in the science magazine Nature. The genetic maps were as different as that of the man and fish.

Aspergillus is a very common air-borne fungus, carried all over the world as spores. Although usually harmless, the species Aspergillus fumigatus was identified as a cause of infection as long ago as 1848 and is now the leading infectious cause of death in vulnerable leukemia and bone marrow transplant patients.

Aspergillus nidulans has been a leading experimental system helping to unravel many fundamental cellular processes for the last 50 years, whilst Aspergillus oryzae has been used in the Far East for 2000 years to produce sake (rice wine), miso (soybean paste) and shoyu (soy sauce).

The researchers have found that the three species only display around 68 percent of the same proteins, a similar percentage to that shared by mammals and fish which diverged 450 million years ago. They also differ considerably in genome size, with Aspergillus oryzae being 31 percent bigger than Aspergillus fumigatus and 24 percent bigger than Aspergillus nidulans.

"Fungi play a critical role in the earth's ecosystem, being responsible for almost all degradation of plant material as well as recycling nitr ogen. Aspergillus fumigatus is a major constituent of compost, and mould fungi have been important sources of drugs including penicillin and cyclosporin," said The David Denning, who coordinated the project.

However, they also produce toxins known as mycotoxins, such as aflatoxin which can cause liver cancer. Aspergillus causes a life-threatening infection for transplant and leukemia patients, as well as being a major allergen for asthmatics.

"Identifying these genome sequences will transform scientific understanding of why this group of fungi is so lethal and allergenic. The importance of the project in helping develop new drugs and diagnostic tests, and understand and prevent allergies and diseases like pneumonia and sinusitis, cannot be overestimated. The information revealed will also develop our understanding of the biology of composting and mycotoxin production, and provide benefits for many other areas of science and medicine," Denning said. (edited ANI)


'"/>




Related medicine news :

1. Decoding the Medicare Code
2. Smell Decoding System In Brain –Research Find
3. Fruit Crop Fungicide Induces Permanent Changes in Mating Behavior
4. Human Genome Project Achieves Technological Triumph
5. Human Diseases May Have Clue In Human-Chimp Genome Difference
6. Race Based Genome Project Launched By Mexico
7. Dog (Mans best friend) Genome Sequenced
8. Yeast Genome Unravels Genes Critical For Maintaining DNA Integrity
9. Unraveling the Secrets of MHC in Human Genome
10. NHGRI Aims To Sequence Primate Genomes
11. p53, the Guardian of Our Genome
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... As health professionals work to improve their approach ... patient is doing more than filling out a survey; in many cases health professionals ... emphasis in health care and research on the importance of active engagement with patients ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family ... next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. ... 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming the ...
(Date:10/13/2017)... ... , ... PurhealthRX , a leading Health and Nutrition Company, is announcing ... full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing the ... incorporated into liquid products, while reducing costs to end users. , The team of ...
(Date:10/13/2017)... ... 13, 2017 , ... Lori R. Somekh, founder of the Law Office ... of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our office ... forum to network with elder law attorneys nationwide,” said Somekh. , ElderCounsel ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Many families ... However, many long-term care insurance companies have a waiver for care if the client ... elimination period, when the family pays for care, is often waived, so the benefits ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... MENLO PARK, Calif. , Oct. 11, 2017 /PRNewswire/ ... a national scientific team that developed an innovative way ... and quantity of the delivery of new drugs. ... the 2017 Fall Clinical Dermatology Conference will show how ... Massachusetts General Hospital, Harvard Medical School used a suite ...
(Date:10/10/2017)... Oct. 10, 2017   West Pharmaceutical Services, Inc. ... for injectable drug administration, today shared the results of ... for improving the intradermal administration of polio vaccines. The ... Summit in May 2017 by Dr. Ondrej Mach ... World Health Organization (WHO), and recently published in the ...
(Date:10/4/2017)... 2017 OBP Medical , a ... devices, today announced regulatory approval from ... Agência Nacional de Vigilância Sanitária (ANVISA)) to market ... retractor with integrated LED light source and smoke ... exposure of a tissue pocket or cavity during ...
Breaking Medicine Technology: