Navigation Links
Death and Disability from Brain Injury Reduced, Emory Researchers Report

About 1.5 to 2 million people in the U.S. sustain a traumatic brain injury (TBI) each year, leading to 50,000 deaths and 80,000 new cases of long-term disability. It also is a major cause of death and disability among children and military personnel.

Despite the enormity of the problem, scientists have failed to identify effective medications to improve outcomes following a TBI. In fact, no new medical therapies have been developed for traumatic brain injuries in over 30 years.

The study gives hope of finally identifying an agent for the treatment of traumatic brain injury - and possibly other neurological injuries such as stroke, spinal cord injury and multiple sclerosis.

"This is the first therapy exists that improves the outcome of brain injury patients," says Dr. Wright. Emory's researchers designed a clinical trial to assess the promise of progesterone for treatment of TBI. Their three-year pilot study, called ProTECT (which stands for "Progesterone for Traumatic brain injury-Experimental Clinical Treatment"), enrolled 100 participants.

The phase II study was primarily designed to evaluate whether progesterone can be administered intravenously in a reliable way, and whether the treatment is safe to use in humans with TBI. The researchers also hoped to find preliminary evidence that the treatment might be effective.

Although it is widely considered a "sex steroid," progesterone is also a neurosteroid that exerts protective effects on human tissue. It is naturally present in small but measurable amounts in the brains of males and females. Laboratory studies suggest that progesterone is critical for the normal development of neurons in the brain and exerts protective effects on damaged brain tissue.

The research team is now planning a large, multi-center, phase III clinical trial designed to test the effectiveness of progesterone in 1,000 patients with TBI. They also hope to study the effects of progesterone treatment in animal models of blast-related brain injury, a major cause of death among combat personnel. Additionally, they plan to implement a study of progesterone to treat pediatric brain injury, which is a leading cause of death and disability in children.


'"/>




Related medicine news :

1. White Cells Count Can Predict Heart Attack Death Risk
2. Bayer Voluntarily Withdraws BAYCOL - A Drug Associated With 50 Deaths
3. AIDS toll set to exceed Black Death
4. Fish Oil Fights Arrhythmias, Sudden Death
5. Painkiller Linked to Deaths
6. Death due to premature heartbeat after exercise
7. Preventing Childhood Deaths
8. Death Risk Higher in Obese Women with Colon Cancer
9. Death Among the Homeless
10. Diabetes on the Increase but Death Rate Falling
11. Drug Users and Risk of Death
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2016)... ... February 11, 2016 , ... Colorado spine surgeon, ... of 334 spine surgeons to know in 2016 . The list consists of ... of spine surgery. , Dr. Corenman understands the importance of clinical excellence; he ...
(Date:2/11/2016)... ... ... The annual list showcases the 20 Most Promising SharePoint Solution Providers in ... commitment to the SharePoint ecosystem. A panel of experts and members of CIOReview’s editorial ... and promote technology entrepreneurship. , The survey was made at the end of ...
(Date:2/11/2016)... San Diego, CA (PRWEB) , ... February 11, 2016 , ... ... Combine which was held in San Diego, CA, on February 6th & 7th, 2016 ... NFL combine for those who were not invited to the NFL’s combine in Indianapolis,” ...
(Date:2/10/2016)... ... , ... President Obama’s budget proposal yesterday enables the HHS ... via telehealth, estimated to generate more than $160 million in savings over 10 ... Although there is more to be done, this represents an important victory ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... , a full-service health care communications company offering education, research and medical ... for practitioners and specialists working in infectious diseases. , As the all-inclusive ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... NEW YORK , Feb. 11, 2016 /PRNewswire/ ... a foot-focused suite of products designed to support ... ExoSOLS™, are custom orthotic insoles that combine years ... 1,000 partners in the podiatric field with cutting ... align, and propel . It is supported by ...
(Date:2/10/2016)... DUBLIN , February 11, 2016 /PRNewswire/ ... the addition of the "Molecular Diagnostics ... --> http://www.researchandmarkets.com/research/rp4pg8/molecular ) has announced ... Reports Bundle" report to their offering. ... http://www.researchandmarkets.com/research/rp4pg8/molecular ) has announced the addition of ...
(Date:2/10/2016)... och PITTSBURGH , ... lämnas inte, och detta pressmeddelande får inte ... eller till, och inga anmälningssedlar kommer att ... i, något land där Erbjudandet, distribution av ... Erbjudandet skulle strida mot tillämpliga lagar eller ...
Breaking Medicine Technology: