Navigation Links
Dartmouth researchers zero-in on a gene that heightens muscle performance

A group of researchers, led by scientists at Dartmouth Medical School and Dartmouth College, have discovered and examined a gene that is capable of changing muscle metabolism and performance. // The researchers are optimistic that this discovery could assist in the management of muscle diseases.

The researchers have found that the enzyme called AMP-activated protein kinase (or AMPK) is responsible for realizing the best muscle activity.

The team bred a mouse that genetically expressed AMPK in an activated state. Like a trained athlete, this mouse enjoyed increased capacity to exercise, manifested by its ability to run three times longer than a normal mouse before exhaustion. One particularly striking feature of the finding was the accumulation of muscle glycogen, the stored form of carbohydrates, a condition that many athletes seek by "carbo-loading" before an event or game. The study appears in the Nov. 14 online issue of the American Journal of Physiology: Endocrinology and Metabolism.

"Our genetically altered mouse appears to have already been an exercise program," says Lee Witters, the Eugene W. Leonard 1921 Professor of Medicine and Biochemistry at Dartmouth Medical School and professor of biological sciences at Dartmouth College. "In other words, without a prior exercise regimen, the mouse developed many of the muscle features that would only be observed after a period of exercise training."

Witters, whose lab led the study, explains that this finding has implication for anyone with a muscle disease and especially for the growing proportion of the population that is aging. Deteriorating muscles often make the elderly much more prone to fall, leading to hip and other fractures. According to Witters, there is tremendous interest in the geriatric field to find ways to improve muscle performance.

"We now wonder if it's possible to achieve elements of muscular fitness without having to exercise, which in turn, raises many questions about possible modes of exercise performance enhancement, including the development of drugs that could do the same thing as we have done genetically," he says. "This also might raise to some the specter of 'gene doping,' something seriously being talked about in the future of high-performance athletes."

Witters says that the carbohydrate, glucose, is a major fuel that powers muscles, and this contributes directly to a muscle's ability to repetitively contract during exercise. The activated AMPK in the Dartmouth mouse appears to have increased glycogen content by actually switching on a gene that normally synthesizes liver glycogen.

"The switching on of this liver gene in muscles," he says, "is a shift in the conception of the biochemistry of muscle metabolism, since many enzyme genes are thought to only be active in just one tissue."

Other authors on the paper include Laura Barré, Christine Richardson, and Steven Fiering, all at Dartmouth; Michael Hirshman and Laurie Goodyear of Joslin Diabetes Center in Boston; Joseph Brozinick with Eli Lilly and Company; and Bruce Kemp of the St. Vincent's Institute in Australia.

This research is funded by the National Institutes of Health.



Source-Eurekalert
'"/>




Related medicine news :

1. Vitamin Extends Life in Yeast, Dartmouth Medical School Researchers Find
2. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
3. Gene researchers make Malaria-resistant mosquito
4. Calcium Supplementation May Not Actually Prevent colon cancer say researchers
5. Lung cancer molecular profile discovered by researchers.
6. A great hope for quitters of smoking by researchers
7. Vitamins may not protect against cancer say researchers
8. Autoimmune disorders studied in detail by U-M researchers.
9. A high BMI may not determine obesity, researchers say
10. Medical researchers being stifled by NHS Red tape
11. Tissue implant scandal heightens FDA’s concer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/10/2016)... ... February 10, 2016 , ... A ... Ohio Safety Congress and Expo event March 9-11, 2016. Hosted by Ohio's Bureau ... Center. , As the longest running and largest worker's compensation event in ...
(Date:2/10/2016)... MD (PRWEB) , ... February 10, 2016 , ... ... to make Everseat digital self-scheduling readily available to physicians. The integration ... patients can find and select appointments via Everseat’s free mobile app. , The ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... Jacksonville, FL 32224, February 26th: Amateur & Professional Divisions - Time: 7:00pm ... 7:00pm – 10:00pm | Ticket Prices $30, Social Media: http://www.USPoleSportsFed.org , ...
(Date:2/10/2016)... ... 10, 2016 , ... Workrite Ergonomics, who is celebrating their 25th year of ... to being an internationally recognized leader in their industry. , "We are very proud ... President of Workrite. “Workrite recognized the importance of good ergonomics before most of ...
(Date:2/10/2016)... ... February 10, 2016 , ... Anxiety of older Americans over ... of Medicare Part D a decade ago, according to The Senior Citizens League ... on how they are coping with rapidly rising costs. “The implications are chilling, ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... Feb. 9, 2016   AllCare Plus Pharmacy ... Gold Seal of Approval ® for Home ... performance standards. The Gold Seal of Approval ® ... commitment to providing safe and effective care.  ... Pharmacy underwent a rigorous on-site survey in January 2016. ...
(Date:2/9/2016)... , Feb. 9, 2016 Hearing protection devices ... sound energy transmitted to the inner ear. Hearing protection ... bands. These devices are recommended for users exposed to ... Earplugs refer to HPD that are inserted in the ... are designed to provide more natural sound perception with ...
(Date:2/9/2016)... LONDON , Feb. 9, 2016 The new report "Global Blood ... Spearhead Acuity Business Research & Consulting group reveals that global market ... 17,770.3 million in 2014 and expected to grow to US$ 24,830.1 ... 2019. North America , Europe ... , Middle-East and Africa ...
Breaking Medicine Technology: