Navigation Links
Dartmouth researchers zero-in on a gene that heightens muscle performance

A group of researchers, led by scientists at Dartmouth Medical School and Dartmouth College, have discovered and examined a gene that is capable of changing muscle metabolism and performance. // The researchers are optimistic that this discovery could assist in the management of muscle diseases.

The researchers have found that the enzyme called AMP-activated protein kinase (or AMPK) is responsible for realizing the best muscle activity.

The team bred a mouse that genetically expressed AMPK in an activated state. Like a trained athlete, this mouse enjoyed increased capacity to exercise, manifested by its ability to run three times longer than a normal mouse before exhaustion. One particularly striking feature of the finding was the accumulation of muscle glycogen, the stored form of carbohydrates, a condition that many athletes seek by "carbo-loading" before an event or game. The study appears in the Nov. 14 online issue of the American Journal of Physiology: Endocrinology and Metabolism.

"Our genetically altered mouse appears to have already been an exercise program," says Lee Witters, the Eugene W. Leonard 1921 Professor of Medicine and Biochemistry at Dartmouth Medical School and professor of biological sciences at Dartmouth College. "In other words, without a prior exercise regimen, the mouse developed many of the muscle features that would only be observed after a period of exercise training."

Witters, whose lab led the study, explains that this finding has implication for anyone with a muscle disease and especially for the growing proportion of the population that is aging. Deteriorating muscles often make the elderly much more prone to fall, leading to hip and other fractures. According to Witters, there is tremendous interest in the geriatric field to find ways to improve muscle performance.

"We now wonder if it's possible to achieve elements of muscular fitness without having to exercise, which in turn, raises many questions about possible modes of exercise performance enhancement, including the development of drugs that could do the same thing as we have done genetically," he says. "This also might raise to some the specter of 'gene doping,' something seriously being talked about in the future of high-performance athletes."

Witters says that the carbohydrate, glucose, is a major fuel that powers muscles, and this contributes directly to a muscle's ability to repetitively contract during exercise. The activated AMPK in the Dartmouth mouse appears to have increased glycogen content by actually switching on a gene that normally synthesizes liver glycogen.

"The switching on of this liver gene in muscles," he says, "is a shift in the conception of the biochemistry of muscle metabolism, since many enzyme genes are thought to only be active in just one tissue."

Other authors on the paper include Laura Barré, Christine Richardson, and Steven Fiering, all at Dartmouth; Michael Hirshman and Laurie Goodyear of Joslin Diabetes Center in Boston; Joseph Brozinick with Eli Lilly and Company; and Bruce Kemp of the St. Vincent's Institute in Australia.

This research is funded by the National Institutes of Health.



Source-Eurekalert
'"/>




Related medicine news :

1. Vitamin Extends Life in Yeast, Dartmouth Medical School Researchers Find
2. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
3. Gene researchers make Malaria-resistant mosquito
4. Calcium Supplementation May Not Actually Prevent colon cancer say researchers
5. Lung cancer molecular profile discovered by researchers.
6. A great hope for quitters of smoking by researchers
7. Vitamins may not protect against cancer say researchers
8. Autoimmune disorders studied in detail by U-M researchers.
9. A high BMI may not determine obesity, researchers say
10. Medical researchers being stifled by NHS Red tape
11. Tissue implant scandal heightens FDA’s concer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/4/2016)... , ... May 04, 2016 , ... ... Continence Nurses (WOCN) Society™ and Canadian Association for Enterostomal Therapy (CAET) will ... time saving and planning tools to attendees and exhibitors for the 2016 WOCN ...
(Date:5/4/2016)... ... May 04, 2016 , ... May kicked off with Melanoma ... United States. Dermatologist Dr. Ellen Turner is encouraging her patients, as well as residents ... on skin safety and health now and in the future. , The dermatology-specific awareness ...
(Date:5/4/2016)... ... , ... Recognizing that lifestyle medicine is essential to health and healthcare, ... Katz, MD, MPH, president of the American College of Lifestyle Medicine, as their first ... gratifying,” said Katz. “There is so much opportunity to add years to lives, and ...
(Date:5/4/2016)... TX (PRWEB) , ... May 04, 2016 , ... ... Nightstick all-LED multi-function small and compact tactical (6.7 inch) dual-light flashlights in models ... Las Vegas, model NSP-9842XL (average retail starting at $59.95) uses 2 included CR-123 ...
(Date:5/4/2016)... ... May 03, 2016 – (PRWEB) May 04, ... child products, today revealed the non-toxic benefits of its Tutti Frutti ... with teething pain is just part of the story. These food-grade, ... BPA-, PVC-, and phthalate-free. , “Many baby toys contain BPA, ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... 3, 2016 BioNovus Innovations LLC and ... Advancing Medical Innovation (IAMI) today announced a new ... and medical devices. An agreement between ... to license, develop and commercialize medical innovations advanced ... "This partnership represents a significant advance in our ...
(Date:5/3/2016)... May 3, 2016  As a teenager, an active ... fever, which damaged his heart. He continued enjoying sports ... June 2013, Shepherd,s heart was giving out and he ... June 20, 2013, the Mesa, Arizona ... (TAH-t). Like a heart transplant, the SynCardia TAH-t is ...
(Date:5/3/2016)... , May 3, 2016  While you may be familiar with watching a film or ... also known as ultra-high-definition or 8MP in the Medical Industry.  Ampronix  is a renowned authorized ... innovative technology. Photo - http://photos.prnewswire.com/prnh/20160502/362730 ... ... ...
Breaking Medicine Technology: