Navigation Links
DNA-bound p53 Tumor Suppressor Protein Structure Determined

More than half of human cancers involve mutations in the p53 tumor-suppressor gene, suggesting the critical role played by the normal p53 protein in defending// against cancer. Similarly, roughly 95 percent of cancer-causing mutations in the p53 protein occur in its DNA-binding core domain, pointing to this region of the p53 protein as being pivotal to its anti-cancer activity.

Clearly, a detailed view of the p53 protein in direct contact with DNA could provide important insights into preventing and treating an array of human cancers. To date, however, despite having learned a good deal about the protein’s biochemistry over the years, scientists have been unable to "see" the protein – using the tools of structural biology – bound to DNA in its naturally occurring form. This naturally occurring form contains a pairing of two p53 proteins, called a dimer, that then binds to a second p53 dimer in a similar way to create the precisely oriented four-protein complex, called a tetramer, that binds DNA.

Now, in a new study featured as a "paper of the week" and on the cover of the July 21 issue of the Journal of Biological Chemistry, researchers at The Wistar Institute have successfully determined the three-dimensional structure of the p53 protein bound as a dimer to DNA and used the structure to produce an accurate model of the p53 tetramer bound to DNA.

"The bottom line is that we now have a detailed picture of how p53 binds DNA," says Ronen Marmorstein, Ph.D., a professor in the Gene Expression and Regulation Program at Wistar and senior author on the study. "Given the fact that p53 is an important tumor suppressor that is mutated in the majority of human cancers, this will undoubtedly be useful information."

Earlier work had shown how p53 binds to DNA as a stand-alone entity, a form that does not represent the natural state of p53 binding to DNA. The present work captures p53 bound to DNA in its natural dimeric units and th
'"/>




Page: 1 2

Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Radiofrequency Energy Cooks Tumors Without Surgery
3. New Liver Tumor Treatment
4. Latest Tumor Classification More Informative
5. New Technique For Benign Breast Tumors
6. Another Treatment Option for Benign Tumors
7. Understanding The Origin Of Tumors
8. Outpatient Treatment Possible For Patients with Uterine Fibroid Tumors
9. Stem Cells, Tumor Cells Share Similar Properties: Scope For Treatment and Prevention?
10. Lipoma Arborescens: A Rare Tumor Of The Knee
11. Researchers Develop Mouse Model Of Brain Tumor
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: DNA bound Tumor Suppressor Protein Structure Determined

(Date:9/20/2014)... TX (PRWEB) September 20, 2014 ... Forecast and Market Analysis to 2023?. The asthma ... decade, as it has become saturated with relatively ... inhaled corticosteroids (ICSs), inhaled corticosteroids and long-acting beta-agonists ... facing increasing generic competition. However, the launch of ...
(Date:9/20/2014)... September 20, 2014 Recently, Best ... site, has launched its new website. The new ... of popular hosting products for customers. Here, people ... make a purchasing decision. Also, it has recommended ... , One of the great web hosting ...
(Date:9/20/2014)... "As a nurse, patients always ask me how much ... Tamaqua, Pa. "The reason that they cannot tell is because ... My invention enables them to check oxygen levels on their ... it easier to monitor the contents of an oxygen tank. ... is low. It allows changeovers to be performed under optimal ...
(Date:9/20/2014)... (PRWEB) September 20, 2014 Earlier this week, ... customers may have had their credit card information pilfered by ... spawning a slew of headline articles like this one ... the only eye opening numbers. , “Most people tend ... almost like it’s a way to score a game,” says ...
(Date:9/20/2014)... Final Cut Pro X Plugin developers ... Information theme for FCPX filmmakers. , “Fun, cool, and simple ... theme,” says Christina Austin, CEO of Pixel Film Studios. “It ... Information features easy to use controls that give the user ... the background color, color of each circle outline, the position ...
Breaking Medicine News(10 mins):Health News:Symbicort Asthma Market Forecasts to 2023 - Overview, Efficacy, Safety & SWOT Analysis in New Report Available at LifeScienceIndustryResearch.com 2Health News:Symbicort Asthma Market Forecasts to 2023 - Overview, Efficacy, Safety & SWOT Analysis in New Report Available at LifeScienceIndustryResearch.com 3Health News:Symbicort Asthma Market Forecasts to 2023 - Overview, Efficacy, Safety & SWOT Analysis in New Report Available at LifeScienceIndustryResearch.com 4Health News:Best Cheap Hosting USA Launches Its New Website And Recommends InMotion To Worldwide People 2Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 2Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 3Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 4Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 5Health News:Today Pixel Film Studios Announced the Release of the Information Theme for Final Cut Pro X 2
... Systems Using New Software That Enables SPECT Procedures ... That Meet New ASNC Technology Standards, ... a leading provider of diagnostic imaging systems and,services to physicians, ... from the U.S. Food and Drug,Administration (FDA) 510(k) clearance for ...
... Enhance Computer Security, ATLANTA, Sept. 22 ... has published the locations,of the computers, from which ... its clients in 2008. The United States topped ... computers within the,country and China ran second with ...
... to eat tomatoes this summer and when tomatoes were vindicated, ... safety expert says there is only so much that can ... "We basically want perfect food, but produce is not sterile," ... MU College of Agriculture, Food and Natural Resources. "We all ...
... Stern + Associates (S+A), the,rapidly growing, full-service ... New Jersey with offices in Cambridge,Mass., has added ... Corporation and the Pain Control product area of ... expanded its public relations,programming for Bracco Diagnostics Inc. ...
... Healthcare’s announcement that it will discontinue several key anesthesia ... to Ohmeda customers. , ... ... DRE, Inc., a premier international http://www.dremed.com [surgical ...
... demonstrating significant effect of new, formulation of Rebif(R) on disease activity ... ... -- Data presented at late-breaking session of the World Congress on ... GENEVA, Sept. 22 Merck Serono, a division of Merck,KGaA, Darmstadt, Germany, ...
Cached Medicine News:Health News:Digirad Corporation Receives FDA 510(k) Clearance for nSPEED(R) Reconstruction Software for Improved Image Quality in Less Time With Less Radiation 2Health News:Digirad Corporation Receives FDA 510(k) Clearance for nSPEED(R) Reconstruction Software for Improved Image Quality in Less Time With Less Radiation 3Health News:Compromised US and Chinese Computers Launch Greatest Number of Cyber Attacks, According to SecureWorks' Data 2Health News:Compromised US and Chinese Computers Launch Greatest Number of Cyber Attacks, According to SecureWorks' Data 3Health News:Is the salad bar safe? Produce concerns linger after summer scares 2Health News:Stern + Associates Signs New Clients to Health Care Practice 2Health News:DRE Medical Equipment Offers Valuable Discounts to GE Healthcare Customers 2Health News:Results From IMPROVE Study Show Therapeutic Effect of New Formulation of Rebif(R) at 16 Weeks in Patients With Multiple Sclerosis 2Health News:Results From IMPROVE Study Show Therapeutic Effect of New Formulation of Rebif(R) at 16 Weeks in Patients With Multiple Sclerosis 3Health News:Results From IMPROVE Study Show Therapeutic Effect of New Formulation of Rebif(R) at 16 Weeks in Patients With Multiple Sclerosis 4Health News:Results From IMPROVE Study Show Therapeutic Effect of New Formulation of Rebif(R) at 16 Weeks in Patients With Multiple Sclerosis 5
(Date:9/19/2014)... 19, 2014  4WEB Medical announces the formal launch ... ankle osteotomy implants on the market today at ... meeting in Chicago .  The Osteotomy ... osteotomy needs with 74 size options included in one ... of only 15 to 18 implant sizes, which limited ...
(Date:9/19/2014)... Merck (NYSE: MRK ), known as MSD ... Canada , is teaming with celebrity chef and cookbook author ... , an educational program encouraging Hispanics with type 2 diabetes to ... goal to help reduce the risk of serious health problems. Hispanics ... higher risk for developing type 2 diabetes than non-Hispanic white adults, ...
(Date:9/19/2014)... 2014  Diplomat, the nation,s largest independent specialty pharmacy, ... to the Board of Directors on September 15, 2014. ... serve as chair of the Audit Committee. ... financial, compliance and operating experience in the health care ... chief financial officer, chief operating officer and secretary of ...
Breaking Medicine Technology:4WEB Medical Unveils 3D-Printed Osteotomy Truss System 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 3Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 5David Dreyer Appointed to Diplomat Board of Directors 2
... AVIV, Israel , June 29, 2010 ... invasive, accurate,diagnosis of heart diseases, announced today that its ... intended for,improved diagnostic performance of Stress ECG, has been ... is an add-on system with the,HyperQ technology which is ...
... ,, NEW YORK , ... the "Company") (NYSE Amex: NBS ), an international ... , announced on June 15, 2010 that ... government,inspection by the State Food and Drug Administration ("SFDA") ...
Cached Medicine Technology:BSP Granted CE Mark for its HyperQ AD-100 Product Enabling Improved Diagnostic Performance of Stress ECG 2NeoStem Pharmaceutical Subsidiary Announces Two cGMP Lines are Now Fully Operational in New Facility 2NeoStem Pharmaceutical Subsidiary Announces Two cGMP Lines are Now Fully Operational in New Facility 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: