Navigation Links
Cytokine IL6 as a New Chemotherapeutic Target for Ras-driven Cancers

Dr. Christopher Counter and colleagues at the Duke University Medical Center have identified IL6 as a new target in the battle against Ras-induced cancers .

Ras is a key intracellular messenger protein that directs, among other things, cell growth and proliferation. Over-expression of the Ras oncogene, or of its growth-promoting pathway, is an integral step in the development of a number of human cancers, particularly pancreatic and lung cancer.

Unfortunately, though, attempts to target Ras for inhibition in a clinical setting have proved unsuccessful.

"We knew Ras was really important for cancer, but time after time it defied attempts to be inhibited in the clinic. So we decided, why not go after something that you can make a drug against that Ras activates"" explains Dr. Counter.

Dr. Counter and colleagues sought to identify other proteins that are secreted when Ras is activated, and evaluate them as potential therapeutic candidates. One factor, in particular, is receiving a lot attention.

Interleukin-6 (IL6) is an inflammatory cytokine (growth factor) that stimulates the immune system in response to injury. Dr. Counters team has demonstrated that Ras induces the secretion of IL6 in a number of different cell types.

The scientists then showed that IL6 promotes tumorigenesis by encouraging new blood vessel growth.

Dr. Counter and colleagues were able to successfully fight tumor formation in a preclinical model by suppressing IL6 activity. While further research is needed to determine the effectiveness of IL6 targeted cancer therapies, these initial results are encouraging.

"Targeting secreted proteins that Ras activates has opened the door to inhibit the oncogenic signal of Ras via druggable proteins," states Dr. Counter.


'"/>




Page: 1

Related medicine news :

1. Experimental Drug Causes Cytokine Storm
2. Drexel Research in Cytokines Could Treat Sepsis
3. Cytokine Resistance Contributes to Pathology of Type 2 Diabetes
4. Target for obesity treatment
5. Gel Offers A More Targeted Approach
6. In Search Of A New Drug To Target Cholesterol
7. In Search Of A New Drug To Target Cholesterol
8. Target of diabetes type 1 identified
9. Gene Target For Tuberculosis Identified
10. New Vaccine Targeted At Effective Treatment Against Tuberculosis
11. Novel Technique For Targeting Small-Cell Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cytokine New Chemotherapeutic Target for Ras driven Cancers

(Date:4/22/2014)... 22, 2014: The Association for Molecular Pathology (AMP) ... of Molecular Diagnostics on recommendations for a ... master,s levels of education. The report was prepared ... Force of the AMP Training and Education Committee. ... of educating future medical laboratory scientists appropriately in ...
(Date:4/22/2014)... NY, April 22, 2014Hemoglobin A1c is the standard measurement ... diabetes. Blood levels of A1c are typically measured every ... developed a data-based model that accurately estimates A1c using ... Diabetes Technology & Therapeutics ( DTT ), a ... article is available free on the DTT ...
(Date:4/22/2014)... To help rein in massive health care spending, a ... urgently find ways to incentivize pharmaceutical companies and device ... Instead of examining existing medical technologies and their use, ... affect what drugs and medical devices get created in ... health care spending with as little loss of health ...
(Date:4/22/2014)... 10 Americans support mandated coverage of birth control medications, ... the University of Michigan Health System. , Women, blacks, ... at home, and adults with private or public insurance ... universal coverage of birth control medications, according to the ... American Medical Association ( JAMA ). , Individuals ...
(Date:4/22/2014)... German . Scientists ... Vienna and the Medical University of Vienna, together with colleagues ... RNA, such as viral genetic information, is prevented from entering ... viral infection, the protein ADAR1 moves from the cell nucleus ... inhibit reproduction of the virus. But how is the human ...
Breaking Medicine News(10 mins):Health News:AMP publishes curriculum recommendations for medical laboratory scientists 2Health News:US medical innovation needs smarter incentives to cut health spending, study finds 2Health News:US medical innovation needs smarter incentives to cut health spending, study finds 3Health News:More than two-thirds of Americans support mandated coverage of birth control in health plans 2Health News:How the body fights against viruses 2Health News:How the body fights against viruses 3
... government, through the U.S. Agency for International Development (USAID), is ... Assistance Response Team (DART) to help combat the cholera outbreak ... than $4.6 million for emergency water, sanitation, and hygiene program ... , This new funding will provide additional ...
... 11 Mary Beth Bolton, MD, FACP, a Detroit internal ... by the Michigan State Medical Society (MSMS). , ... Chief Medical Officer with Health Alliance Plan (HAP) since 2000, ... career-long commitment to improving primary patient care through increasing access, ...
... to "Tell Their Stories" , , ... that healthcare reform will be a top priority in his ... serve as health and human services secretary, is the leader ... to help with reform efforts by sharing their healthcare experiences ...
... million people die every year from infectious diseases, ... The discovery of penicillin to treat bacterial ... previously incurable virus diseases such as polio and ... mid-20th century. , Recently, spectacular advances in medical ...
... company, announced today that beginning January 1, 2009, ... for incomplete spinal cord injury patients suffering from ... Medicare and Medicaid Services (CMS) establishes a new ... devices including the NESS L300™ Foot Drop System. ...
... GLENVIEW, IL, Dec. 11, 2008 Federal funding for pain research ... according to a new study published in The Journal of ... only 0.6 percent of all grants awarded by the National Institutes ... the U.S. , "This startling finding shows the government,s ...
Cached Medicine News:Health News:USAID Provides Additional $6.2M for Zimbabwe Cholera Outbreak 2Health News:Mary Beth Bolton, MD, Named 'Woman Physician of the Year' by Michigan State Medical Society 2Health News:Hospice Community Encouraged to Respond to Daschle Request to Participate in Information Gathering about Healthcare Concerns 2Health News:Mathematical models of adaptive immunity 2Health News:Mathematical models of adaptive immunity 3Health News: Medicare to Reimburse for the Bioness L300™ Foot Drop System for Spinal Cord Injury 2Health News: Medicare to Reimburse for the Bioness L300™ Foot Drop System for Spinal Cord Injury 3Health News:Study shows major pain research funding decline at NIH 2
(Date:1/14/2014)... North America,s leading business partnering event ... 30 th edition of its annual conference at the ... 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ) ... specialty chemical companies will take part in the conference, which ...
(Date:1/14/2014)... Emergency Critical Care, a LifeCentre partner practice, located at 165 Fort ... first in Loudoun County to receive a ... M. Barnes , Medical Director, is a well-seasoned veterinarian of more ... , are avid scuba divers. "As altitude skiers and hikers, we ...
(Date:1/14/2014)... 14, 2014 Equashield ( http://www.equashield.com ... drugs, today announced that it has achieved 60% ...   Equashield,s closed systems reduce the ... and other medical professionals who prepare and administer ...
Breaking Medicine Technology:Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Equashield's Sales Grow by 60% in 2013 2
...  Cell Therapeutics, Inc. ("CTI") (NASDAQ and MTA: CTIC) ... granted a positive opinion for conditional approval from ... Products for Human Use ("CHMP"). Based on the ... authorization for Pixuvri should be granted by the ...
...  A new look at the three most highly regarded ... of its kind to consider long-term cost and quality ... prostatectomy surgery and brachytherapy to be less expensive and ... the treatment of prostate cancer . ...
Cached Medicine Technology:European Medicines Agency's Committee For Medicinal Products For Human Use Issues Positive Opinion For Conditional Approval On Marketing Authorization Application For Pixuvri™ 2European Medicines Agency's Committee For Medicinal Products For Human Use Issues Positive Opinion For Conditional Approval On Marketing Authorization Application For Pixuvri™ 3European Medicines Agency's Committee For Medicinal Products For Human Use Issues Positive Opinion For Conditional Approval On Marketing Authorization Application For Pixuvri™ 4European Medicines Agency's Committee For Medicinal Products For Human Use Issues Positive Opinion For Conditional Approval On Marketing Authorization Application For Pixuvri™ 5Prostate Cancer Treatment Options Go Head-to-Head 2Prostate Cancer Treatment Options Go Head-to-Head 3
MDI will work with your facility to determine the best interim lab to fit your needs and your site....
... large number of mobile, modular and transportable ... fleet. The labs are typically leased to ... The Cath Lab Leasing Company allows hospitals ... upgrading existing equipment, initiating a new service ...
... PowerSuite holmium laser combines excellent cutting, ... virtually bloodless procedures. It is also ... gall bladder stones of all compositions, ... tool. Because its laser light is ...
... technology has allowed for perfecting mini-invasive endoscopic ... various pathologies with a considerable social impact. ... reducing the post-operatory times and represents a ... in all hospital structures.,DEKAs family of Nd:YAG ...
Medicine Products: