Navigation Links
Cytokine IL6 as a New Chemotherapeutic Target for Ras-driven Cancers

Dr. Christopher Counter and colleagues at the Duke University Medical Center have identified IL6 as a new target in the battle against Ras-induced cancers .

Ras is a key intracellular messenger protein that directs, among other things, cell growth and proliferation. Over-expression of the Ras oncogene, or of its growth-promoting pathway, is an integral step in the development of a number of human cancers, particularly pancreatic and lung cancer.

Unfortunately, though, attempts to target Ras for inhibition in a clinical setting have proved unsuccessful.

"We knew Ras was really important for cancer, but time after time it defied attempts to be inhibited in the clinic. So we decided, why not go after something that you can make a drug against that Ras activates"" explains Dr. Counter.

Dr. Counter and colleagues sought to identify other proteins that are secreted when Ras is activated, and evaluate them as potential therapeutic candidates. One factor, in particular, is receiving a lot attention.

Interleukin-6 (IL6) is an inflammatory cytokine (growth factor) that stimulates the immune system in response to injury. Dr. Counters team has demonstrated that Ras induces the secretion of IL6 in a number of different cell types.

The scientists then showed that IL6 promotes tumorigenesis by encouraging new blood vessel growth.

Dr. Counter and colleagues were able to successfully fight tumor formation in a preclinical model by suppressing IL6 activity. While further research is needed to determine the effectiveness of IL6 targeted cancer therapies, these initial results are encouraging.

"Targeting secreted proteins that Ras activates has opened the door to inhibit the oncogenic signal of Ras via druggable proteins," states Dr. Counter.


'"/>




Page: 1

Related medicine news :

1. Experimental Drug Causes Cytokine Storm
2. Drexel Research in Cytokines Could Treat Sepsis
3. Cytokine Resistance Contributes to Pathology of Type 2 Diabetes
4. Target for obesity treatment
5. Gel Offers A More Targeted Approach
6. In Search Of A New Drug To Target Cholesterol
7. In Search Of A New Drug To Target Cholesterol
8. Target of diabetes type 1 identified
9. Gene Target For Tuberculosis Identified
10. New Vaccine Targeted At Effective Treatment Against Tuberculosis
11. Novel Technique For Targeting Small-Cell Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/25/2017)... , ... July 25, 2017 , ... ... announce the launch of their partnership to provide the Pharmacist eCare Plan ... pharmacy-focused platform in the country with the ability to develop the Pharmacist eCare ...
(Date:7/25/2017)... ... July 25, 2017 , ... ... director. Dr. Negrette has more than a decade of experience in psychiatry, treating ... with individuals fighting addictions, eating disorders, psychotic and manic conditions, as well as ...
(Date:7/24/2017)... JACKSONVILLE, Florida (PRWEB) , ... ... ... Klaproth, Division Marketing Director,      (407) 916-7235, kklaproth(at)robinsmorton(dot)com , Robins ... guests joined together to celebrate the structural topping out of the new ...
(Date:7/24/2017)... ... 24, 2017 , ... Horizon Goodwill Industries, SourceAmerica ... helps high school girls succeed in STEM programs as well as help Horizon ... host over 20 high school girls at their corporate headquarters on Tuesday, July ...
(Date:7/24/2017)... ... July 24, 2017 , ... Axiad IDS , a leading provider of ... with WALLIX to expand its solution to help government contractors more quickly ... number of ways to address the authentication requirements within NIST SP800-171, but no ...
Breaking Medicine News(10 mins):
(Date:7/12/2017)... is a revolutionary new product that relieves painful carpal tunnel syndrome ... affects more than 8 million people a year. Women suffer from ... methods of treating CTS are painful surgery, the use of NSAIDs ... ... a clear patch worn on the palm of the hand. It ...
(Date:7/11/2017)... Research Corp., also known as ,The Epigenetics Company, announced today the release ... manner using the myDNAge ™ test. Based on Horvath,s Clock, so ... and biostatistics at the David Geffen School of Medicine at UCLA ... DNAge ™ technology is used to analyze DNA methylation patterns of ... ...
(Date:7/11/2017)...  The global market for liquid biopsy diagnostic and ... in 2016.  Although in early stages, the global market ... as a result of the gradual shift towards personalized ... of a significant number of new liquid biopsy tests ... biomarkers to guide treatment decisions. ...
Breaking Medicine Technology: