Navigation Links
Cystatin C Test- A Reliable Test to Detect Chronic Health Risks

The Cystatin C test appears to be a good alternative for identifying risks for kidney disease, cardiovascular disease, that the creatinine test might miss//. A study conducted by a researcher at the San Francisco VA Medical Center, has shown the inefficacy of routine kidney function test that is incapable of picking up chronic health risks among the elderly.

"For the clinician who treats older people or others at risk for kidney disease, this is an important message: A normal creatinine level should not reassure you that your patient has normal kidney function," says lead author Michael Shlipak, MD, chief of general internal medicine at SFVAMC and an associate professor of medicine, epidemiology, and biostatistics at the University of California, San Francisco. "It shows that cystatin is a very promising new tool that complements creatinine in the ongoing effort to detect early kidney disease and prevent its complications."

The study appears in the August 15, 2006 issue of Annals of Internal Medicine.

Shlipak and his colleagues tested blood samples from 4,663 elders living independently in the community who participated in the Cardiovascular Health Study, a national longitudinal study of people aged 65 and older sponsored by the National Institutes of Health.

The researchers measured each participant's creatinine – an end-product of muscle metabolism that is filtered through the kidneys and has been a standard marker of kidney health for "probably 100 years," according to Shlipak – and cystatin C, a blood protein that is also filtered through the kidneys. They then matched test results with health outcomes up to nine years later.

Among participants with no diagnosed chronic kidney disease, those with high levels of cystatin C had significantly greater risk for poor health than those with normal cystatin C levels. Individuals in the high cystatin group were 50 percent more likely to die overall, nearly twice as l ikely to die of cardiovascular problems, and 30 percent more likely to die of non-cardiovascular problems. They had increased risks of 40 percent for heart failure, 30 percent for heart attack, and 20 percent for stroke. Finally, they were more than three times more likely to develop chronic kidney disease.

"In contrast," the researchers report, "creatinine concentrations had associations with each outcome that were much weaker, and significant only for the outcome of cardiovascular death."

Shlipak says, "This tells us that the creatinine test, while broadly useful as a measure of kidney health, is insensitive. If a creatinine level is high, that's probably an indication of kidney disease. But if it's low, you don't know. You would need to do a cystatin test if there's any other indication of kidney disease or if the patient is in a group that's at risk."

Groups at risk for chronic kidney disease include people over 65, people with diabetes, hypertension, or cardiovascular disease, and African Americans, American Indians, and Hispanic Americans.

"This is also telling us that kidney function declines much more with age than we realized before," adds Shlipak. He terms this syndrome "pre-clinical kidney disease," or pre-CKD.

"We have the tools to slow kidney disease," he notes, including blood pressure control, sugar control for diabetes, and specific medications known as ACE inhibitors. "It's well-established that end-stage kidney disease is rising at a rate of 10 to 20 percent per year. With a heightened awareness of pre-CKD, we can be more aggressive in taking steps to prevent it."

Accurate knowledge of kidney function is also a matter of patient safety, according to Shlipak: "Surgery, some other medical procedures, and certain medications all can have an adverse impact on kidney health."

The cystatin test itself is relatively inexpensive and already widely available, he says. "As deman d for it increases, it should become even more commonly available."

The next steps for researchers, says Shlipak, should include longitudinal studies that determine whether a screening test for cystatin C can improve clinical care and health outcomes for large patient populations. "We also want to map out the physiologic consequences of early mild kidney dysfunction, now that we can measure it."

Source : Eureka Alert


'"/>




Related medicine news :

1. Test-tube babies show no emotional problems
2. First Test-tube Baby Set to Become a Mother Herself
3. Shortness Of Breath A More Reliable Indicator Of High Risk Cardiac Disease
4. Are Conventional Tests for Heart attacks Reliable?
5. Reliable Help For Smokers From Nicotine Patches and Former Smokers
6. Parents – Teen’s Most Reliable Source for Sex Educatin
7. Male Contraceptives-Soon to be Reliable and Reversible
8. Are Alternative Therapies A Reliable Alternative?
9. Doctors Find Internet A Reliable Tool For Diagnosing Diseases
10. Mifepristone Reliable For Treating Uterine Fibroids
11. Are Computer-aided Mammogram Reports Reliable?
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... NY (PRWEB) , ... March 24, 2017 , ... ... scale; from third world countries to hospitals in the United States, it’s a ... conversation on the current obstacles facing infection prevention and offers strategies for the ...
(Date:3/24/2017)... ... March 24, 2017 , ... According to a new study by NCPA ... does not obey the rules Congress has directed the CBO to follow. The CBO ... reform would restore. Yet, it estimates a reduction in employer-based coverage due to the ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... planning, and related services to families and business owners across eastern Michigan, is ... feeding regional families struggling with financial difficulties. , The Oxford/Orion FISH Food Pantry ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... Society (ONS) wanted to create a communications platform that positions them as the ... Elliance and ONS reinvented their online publication as an always-on, always-fresh news, views ...
(Date:3/24/2017)... Westchester County, NY (PRWEB) , ... March 24, 2017 , ... ... in Somers and White Plains, N.Y., is pleased to announce Westchester resident Lauren C. ... as a law clerk for the firm, will concentrate her practice in elder law, ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)...   The Accreditation Council for Medical Affairs ... the pharmaceutical industry has appointed Dr. Jane ... formed scientific advisory board. Dr. Chin will be ... ever medical affairs think tank within the pharmaceutical ... ACMA, please visit  www.medicalaffairsspecialist.org .  Connect with ...
(Date:3/24/2017)... , Mar. 24, 2017 Research and Markets ... Pipeline Analysis, 2016" report to their offering. ... The IPF pipeline is very strong with a ... Merck & Co., Inc., Biogen and Sanofi are involved in the development ... of which one is in Phase III stage, 15 are in Phase ...
(Date:3/24/2017)... March 24, 2017 Today Stock-Callers.com have ... which are: Neovasc Inc. (NASDAQ: NVCN), Hologic Inc. (NASDAQ: HOLX), ... SSH ). These companies are part of the ... on Thursday, March 23 rd , 2017, with the NYSE ... of health care companies in the S&P 500 were down ...
Breaking Medicine Technology: