Navigation Links
Crucial Gene may Be Indicator of Breast Cancer Metastasis

Researchers at Fox Chase Cancer Center have zeroed in on a crucial gene, thought to be the reason for the spread of breast cancer and resistance// to long-term estrogen deprivation. The gene may be beneficial in ascertaining the risk factors of breast cancer reappearance, and would enable a good idea to specialists about potential treatment options.

The research targeted breast cancer cells which had developed resistance to a particular class of anti-hormone drug called aromatase inhibitors. These inhibitors cause the closure of an enzyme aromatase, which causes the body to produce estrogen outside the ovaries. These drugs offer the most effective hormone therapies for women whose estrogen in the body propels the growth of cancer cells.

Fox Chase Cancer Center biochemist Joan S. Lewis-Wambi, Ph.D said, "Unfortunately, one of the drawbacks to extended use of an AI may be that some of the cancer cells develop resistance to the drug and are able to grow and spread independent of estrogen. Our laboratory has developed several AI-resistant breast cancer cell lines and have found that these cells are very invasive compared to AI-sensitive breast cancer cells. Analyses of gene activity in these AI-resistant cells have shown that they express high levels of genes associated with invasiveness and metastasis."

The researchers also found a solution, to employ molecules called "small interfering RNAs" which would quash the gene called CEACAM6 (carcinoembryonic antigen-related cell adhesion molecule6). Lewis-Wambi concluded, “Overall, these findings identify CEACAM6 as a unique mediator of the aggressiveness and spread of AI-resistant breast cancer. This suggests that it might be an important biomarker for metastasis and a possible target for novel treatments for patients with metastatic breast cancer.”
SAV/
'"/>




Page: 1

Related medicine news :

1. Fear Factor Found To Be Crucial In Shaping An Individual’s Personalit
2. Prevention And Control Of Diabetes Crucial To Indian Population
3. Media Plays Crucial Role In Flu Vaccinations
4. Farming Plays A Crucial Role In Reducing Global Warming
5. Crucial steps taken by the Chinese government to protect its grasslands
6. Eye Hygiene Crucial To Keep Fungus at Bay
7. Crucial to regulate your body pH, key determiner for good health
8. Heart Has Enough Oxygen to Survive Hypothermia; CPR Crucial
9. Timely Detection of Type-1 Diabetes Crucial
10. Scientist Discovers Crucial Part of Blood-Clotting Process
11. Genetics Plays A Crucial Role In Preemies Destructive Eye Disease
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Crucial Gene may Indicator Breast Cancer Metastasis

(Date:7/28/2014)... 28, 2014 A lush green lawn offers ... the summer. However, the summer heat, lack of rain, foot ... brown, weak and unhealthy. The Grounds Guys recommends these suggestions ... a lawn once a week and set the height on ... protects the grass roots from heat and allows roots to ...
(Date:7/28/2014)... 2014 An estimated 68,000 women and ... breast and prostate cancers – an aggressive form of ... to other parts of the body, such as the ... Drexel University College of Medicine have developed a ... metastatic progression by blocking tumor cells from “re-seeding.” Their ...
(Date:7/28/2014)... Ticket Down is reliable source for cheap ... at the Cotton Bowl. The 2014 Guinness International Champions Cup ... an eight team tourney. The tournament participants are top ... Liga, Serie A, English Premier League, and Superleague Greece. ... pitch include: Manchester United, Manchester City, Olympiacos, Inter Milan, ...
(Date:7/28/2014)... 28, 2014 Ticket Down is ... in Miami, FL at the Sun Life Stadium in ... football between Argentina and Brazil has is one that has ... more rivalries are forming on a consistent basis. The ... new height in the recent 2014 World Cup. To ...
(Date:7/28/2014)... Steven Reinberg HealthDay Reporter ... dementia and heart rhythm irregularities are more likely to get ... In fact, the study of more than 16,000 people ... more likely to get a pacemaker than those without the ... is why folks with dementia are so much more likely ...
Breaking Medicine News(10 mins):Health News:Nurturing Lawns in the Summer Heat: The Grounds Guys® Offers Tips on Caring for Lawns This Summer 2Health News:Drexel Scientists Develop Compound to Stop Spread of Metastatic Cancer Cells 2Health News:Drexel Scientists Develop Compound to Stop Spread of Metastatic Cancer Cells 3Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Cuts Ticket Prices for AS Roma vs. Real Madrid International Champions Cup Tickets 2Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Cuts Ticket Prices for AS Roma vs. Real Madrid International Champions Cup Tickets 3Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Showdown 2Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Showdown 3Health News:Pacemakers Common for Those With Dementia and Irregular Heartbeats 2Health News:Pacemakers Common for Those With Dementia and Irregular Heartbeats 3
... ... will host two international events for Valentine,s weekend in Las Vegas: ... Rugby teams and the Power Pilates "Power Higher" Conference will host ... 16 national rugby teams, Pilates professionals and thousands of spectators from ...
... from University Hospital in Umea, Sweden, have identified several ... to rheumatoid arthritis (RA) disease onset. These findings ... risk of developing RA can be predicted and disease ... are published in the February issue of Arthritis ...
... Three new regional research centres that will study ... $6 million over five years from the Canadian Institutes ... of Health, made the announcement today at a national ... gender and health research. "Violence is a major ...
... , IRVINE, ... Cat College has commenced, but it,s not too late to register ... 2010 . , Cat College, sponsored by Eukanuba brand cat food, ... premier cat publication, and CatChannel.com, the leading online destination for cat ...
... who had brain or other central nervous system cancers, ... general public, according to an article published online January ... Institute . This study was undertaken because previous ... small, had contradictory findings, or were not population-based. ...
... study of Parkinson,s disease in the United States has found ... the Northeast and is twice as likely to strike whites ... on data from 36 million Medicare recipients, is both the ... disease in minorities and to show geographic clusters for the ...
Cached Medicine News:Health News:Rugby & Pilates Have a Date for Valentine's Weekend in Vegas 2Health News:Rugby & Pilates Have a Date for Valentine's Weekend in Vegas 3Health News:Rugby & Pilates Have a Date for Valentine's Weekend in Vegas 4Health News:Rugby & Pilates Have a Date for Valentine's Weekend in Vegas 5Health News:Blood test can predict rheumatoid arthritis before symptoms arise 2Health News:Government of Canada invests in research to help prevent violence 2Health News:Eukanuba Partners With Cat Fancy(R) to Launch Cat College 2Health News:Eukanuba Partners With Cat Fancy(R) to Launch Cat College 3Health News:Eukanuba Partners With Cat Fancy(R) to Launch Cat College 4Health News:US Parkinson's rates highest in whites, Hispanics, and Midwest, Northeast 2
(Date:7/28/2014)... 28, 2014 Southern Research Institute today ... President and CEO of Southern Research Institute, has ... (CRS) for the 2014-2015 term.  The inauguration took ... 12 in Chicago with ... The Controlled Release Society is an international, ...
(Date:7/28/2014)... AUSTIN, Texas , July 28, 2014  MedSpring Urgent Care, ... new walk-in clinic at 517 S. Lamar Blvd., Austin, ... urgent care clinic is located on the southeast corner of ... doctor on-site from 9 a.m. - 9 p.m. daily, including weekends ... University of Texas, Central Austin , Anderson ...
(Date:7/28/2014)... , July 28, 2014 /PRNewswire/ ... in lifestyle healthcare and subsidiary of ... has acquired Physician Recommended Nutriceuticals (PRN) ® ... and related products for dry eye ... in a transaction worth up to ...
Breaking Medicine Technology:Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 2Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 3MedSpring Urgent Care opens Barton Springs walk-in clinic in Austin, TX 2ALPHAEON Acquires PRN, A Leading Specialty Nutriceutical Company 2ALPHAEON Acquires PRN, A Leading Specialty Nutriceutical Company 3
... HILDEN, Germany, August 16, 2011   ... patients with non-small cell lung cancer (NSCLC) ... whether there is a subset of patients who are more likely ... Collaboration in lung cancer follows QIAGEN ...
... 2011 /PRNewswire-Asia-FirstCall/ -- 3SBio Inc. (NASDAQ: SSRX ... company focused on researching, developing, manufacturing and marketing biopharmaceutical ... second quarter and first half ended June 30, 2011. ... Total net revenues increased by 29.0% over ...
Cached Medicine Technology:QIAGEN and Pfizer Partner to Develop Companion Diagnostic for Novel Compound in Global Clinical Trials for Lung Cancer 2QIAGEN and Pfizer Partner to Develop Companion Diagnostic for Novel Compound in Global Clinical Trials for Lung Cancer 3QIAGEN and Pfizer Partner to Develop Companion Diagnostic for Novel Compound in Global Clinical Trials for Lung Cancer 4QIAGEN and Pfizer Partner to Develop Companion Diagnostic for Novel Compound in Global Clinical Trials for Lung Cancer 53SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 23SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 33SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 43SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 53SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 63SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 73SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 83SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 93SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 103SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 113SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 123SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 133SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 143SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 153SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 163SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 173SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 183SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 19
... Like our coat apron, weight ... allowing hours of comfortable wear without ... body movement, our front closing special ... access "Velcro closures that make it ...
... Wolfs Easy Wrap Apron has ... because theyre easy to put-on, adjust ... even more comfortable! The new Easy ... to adjust the fit more easily. ...
... EEG is an extremely modular and flexible system that ... your patient is in the comfort of their home. ... worn in a lightweight pouch. The alkaline batteries are ... medium used is a standard flash memory card. EEG ...
... The GUARDIAN® Limb Salvage System offers ... The materials used to make these components ... and titanium. All GUARDIAN products are extensions ... knee replacement products. , ,The distal ...
Medicine Products: