Navigation Links
Crucial Gene may Be Indicator of Breast Cancer Metastasis

Researchers at Fox Chase Cancer Center have zeroed in on a crucial gene, thought to be the reason for the spread of breast cancer and resistance// to long-term estrogen deprivation. The gene may be beneficial in ascertaining the risk factors of breast cancer reappearance, and would enable a good idea to specialists about potential treatment options.

The research targeted breast cancer cells which had developed resistance to a particular class of anti-hormone drug called aromatase inhibitors. These inhibitors cause the closure of an enzyme aromatase, which causes the body to produce estrogen outside the ovaries. These drugs offer the most effective hormone therapies for women whose estrogen in the body propels the growth of cancer cells.

Fox Chase Cancer Center biochemist Joan S. Lewis-Wambi, Ph.D said, "Unfortunately, one of the drawbacks to extended use of an AI may be that some of the cancer cells develop resistance to the drug and are able to grow and spread independent of estrogen. Our laboratory has developed several AI-resistant breast cancer cell lines and have found that these cells are very invasive compared to AI-sensitive breast cancer cells. Analyses of gene activity in these AI-resistant cells have shown that they express high levels of genes associated with invasiveness and metastasis."

The researchers also found a solution, to employ molecules called "small interfering RNAs" which would quash the gene called CEACAM6 (carcinoembryonic antigen-related cell adhesion molecule6). Lewis-Wambi concluded, “Overall, these findings identify CEACAM6 as a unique mediator of the aggressiveness and spread of AI-resistant breast cancer. This suggests that it might be an important biomarker for metastasis and a possible target for novel treatments for patients with metastatic breast cancer.”
SAV/
'"/>




Page: 1

Related medicine news :

1. Fear Factor Found To Be Crucial In Shaping An Individual’s Personalit
2. Prevention And Control Of Diabetes Crucial To Indian Population
3. Media Plays Crucial Role In Flu Vaccinations
4. Farming Plays A Crucial Role In Reducing Global Warming
5. Crucial steps taken by the Chinese government to protect its grasslands
6. Eye Hygiene Crucial To Keep Fungus at Bay
7. Crucial to regulate your body pH, key determiner for good health
8. Heart Has Enough Oxygen to Survive Hypothermia; CPR Crucial
9. Timely Detection of Type-1 Diabetes Crucial
10. Scientist Discovers Crucial Part of Blood-Clotting Process
11. Genetics Plays A Crucial Role In Preemies Destructive Eye Disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... 2016 , ... EB Medicine presented its first-ever “Issue of ... in Ponte Vedra Beach, FL. The awards honor the outstanding work of leading ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the efforts ...
(Date:6/24/2016)... ... 2016 , ... National recruitment firm Slone Partners is pleased to ... genomics experience, as Vice President of North American Capital Sales at HTG Molecular ... the sales team in the commercialization of the HTG EdgeSeq system and associated reagents ...
(Date:6/24/2016)... ... ... Finally, a bruise cream that really works. Originally designed to reduce ... post-surgical treatment plans of a variety of other procedures including, but not limited to, ... bruising and causes a rapid resolution of bruising and inflammatory changes compared to no ...
(Date:6/24/2016)... ... 24, 2016 , ... SpiritQuest Sedona Retreats, located in Arizona has re-located to ... vortex sites: Cathedral Rock, Airport Mesa, and Boynton Canyon. The new retreat center ... as well as the Sedona Rouge, both popular accommodations for SpiritQuest clients. The ...
(Date:6/23/2016)... ... 23, 2016 , ... vcfo, a consulting firm that provides ... announce the promotion of Mike Mackey to Regional Vice President of Southeast Texas. ... responsible for managing client projects and overseeing vcfo financial consultants in the Houston ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 According to ... Type (Standard Pen Needles, Safety Pen Needles), Needle Length ... Growth Hormone), Mode of Purchase (Retail, Non-Retail) - Trends ... report studies the market for the forecast period of ... USD 2.81 Billion by 2021 from USD 1.65 Billion ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced ... as its e-clinical software solution of choice.  This ... best possible value to their clients by offering ... The preferred relationship establishes nowEDC as the EDC ... for MedSource,s full-service clients.  "nowEDC has long been ...
(Date:6/23/2016)... 23, 2016  In a startling report released today, National ... by lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... of how states are tackling the worst drug crisis in recorded ... – Kentucky , New Mexico ... . Of the 28 failing states, three – Michigan ...
Breaking Medicine Technology: