Navigation Links
Cough and Phlegm Cause Fourfold Increase in COPD Incidence

Young adults (ages 20 to 44) with normal lung function who later develop chronic cough and phlegm// have a fourfold higher risk of developing chronic obstructive pulmonary disease (COPD).

The results of this 10-year respiratory study appear in the first issue for January 2007 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Isa Cerveri, M.D., of the Division of Respiratory Diseases at San Matteo Hospital and University of Pavia in Italy, and 19 associates showed that the presence of chronic cough and phlegm among study participants was an independent and statistically significant predictor of COPD. Of the 5,002 individuals in the study cohort, 123 were diagnosed with COPD. All participants had normal lung function at baseline.

COPD is the fourth leading cause of death in the United States, killing 122,283 Americans in 2003. It results from chronic bronchitis and emphysema, two lung diseases which frequently co-exist and cause obstruction to airflow that interferes with normal breathing. Smoking is the primary cause of COPD.

“In a large international cohort of individuals from ages 20 to 44, the 10-year cumulative incidence of COPD was 2.8 percent,” said Dr. Cerveri. “It was 4.6 percent in adults aged 40 to 44. This finding points out that COPD is a major health problem even in young adults who are usually not considered to be at risk. In agreement with previous research, we found that the progression toward airflow obstruction is a continuous and gradual process, where sudden changes are extremely unlikely.”

Among the study group, about 77 percent of the 123 COPD cases were smokers. In the sample as a whole, about 55 percent smoked.

The authors noted their results confirm that, from a public health perspective, the prevention of smoking and smoking cessation are the most effective strategies to deter the occurrence of COPD and reduce its burden.

“Our results show that the presence of chronic cough and phlegm is not an innocent symptom, but is an early marker of airflow obstruction,” said Dr. Cerveri.

In addition to cough and phlegm in participants, researchers considered such factors as sex, age, dyspnea (breathlessness), smoking habits and level of education. All participants received lung function tests and blood workups at the beginning and end of the study.

In an editorial on the research in the same issue of the journal, J?rgen Vestbo, M.D., of Hvidovre University Hospital in Denmark and the University of Manchester in the United Kingdom, wrote: “The virtue of the study by Drs. Cerveri and colleagues lies in its size and thus the ability to calculate estimates with acceptable reliability. In this respect, it adds to previous work from the same group and indicates that the statement ‘15 percent of smokers will develop COPD’ is wrong and that lifetime risk of COPD in smokers is significantly higher, probably about 35 to 50 percent.”

He continued: “The predictive value of chronic cough and phlegm is probably more surprising given the fact that this cohort was young and had normal lung function at baseline.”

Dr. Vestbo concluded: “How does the study impact our understanding of the natural history of COPD? As recently reported in this journal, it has taken the respiratory community a painstakingly long time to do properly sized studies in young adults with sound methodology and state-of-the-art analysis. With COPD epidemiology growing in the European Community Respiratory Health Survey and other cohorts of young adults, we may get a better picture of early events in COPD---although our colleagues in pediatric epidemiology will probably continue to claim that we are still only looking at ‘the elderly’!”


Related medicine news :

1. Cough Syrup Ingredient Linked to Stroke
2. Women Worse Affected By Chronic Cough
3. A Drug That Might Relieve Chronic Cough
4. Studying The Effectiveness Of Cough Syrups
5. Foods Rich In Flavonoids Effective In Prevention Of Cough
6. Cough medication to cure fibromyalgia
7. Study Warns About The Use Of Popular Asthma Drug To Stop Childrens Coughs
8. Rising Rates of Whooping Cough in Idaho
9. Cough Syrups No More Effective Than Sugar Water
10. Bariatric Surgery: Medicare, Will Now Cough Up For ‘Throwing Weight
11. Zimbabweans Will Need To Cough Up More on Health Costs
Post Your Comments:

(Date:11/25/2015)... , ... November 25, 2015 , ... ... announced that it has undertaken significant expansion of its current state of the ... is part of PharmaTech’s strategy to increase its manufacturing capacity as well as ...
(Date:11/25/2015)... ... November 25, 2015 , ... Since its launch in ... involving adult stem cell therapies to patients with chronic degenerative medical conditions. Now, ... a Registered Trademark (RTM). , Organizations are required to hold a registered trademark ...
(Date:11/24/2015)... ... November 24, 2015 , ... Eric C. Seidel, DMD and ... of the revolutionary BIOLASE WaterLase iPlus 2.0™ system. This advanced laser technology uses ... a dentist in Gettysburg, PA . From routine visits to cosmetic treatments, ...
(Date:11/24/2015)... Dallas, Texas (PRWEB) , ... November 24, 2015 , ... ... of all charitable donations are made in the last five weeks of the year ... #GivingTuesday was created in 2012 to connect the nation’s charities with those individuals who ...
(Date:11/24/2015)... ... November 24, 2015 , ... DMG Productions announced that they will ... first quarter 2016 via Discovery Channel. Dates and show times TBA. , Aphria, Inc., ... in the business of producing and supplying medical marijuana pursuant to the Marijuana for ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... BOULDER, Colo. , Nov. 24, 2015 /PRNewswire/ ... announced that its Chief Executive Officer, Ron ... Annual Healthcare Conference in New York.  The public ... a webcast on the Array BioPharma website.Event:Piper Jaffray ... OfficerDate:  , Wednesday, December 2, 2015Time:1:30 p.m. Eastern ...
(Date:11/24/2015)... , Nov. 24, 2015  DILON Diagnostics and GE ... an agreement for DILON to distribute GE,s Discovery NM750b ... globe. The signing of this distribution agreement will provide Dilon,s ... Breast Imaging system and is considered an initial step ... healthcare solutions for clinicians and their patients. ...
(Date:11/24/2015)... . --> ... Latest Guidebook for Chinese Medical Device GMP Regulations ... November 2015 to the medical devices market data ... . China ... economies with a fifth population in the world, ...
Breaking Medicine Technology: