Navigation Links
Cost-effective Treatments for Breast Cancer

New adjuvant treatments for breast cancer are cost-effective at improving survival, according to two new studies. A peer-reviewed journal of the American Cancer Society, looked at the cost-effectiveness of different drugs for the management of adjuvant therapies for early breast cancer.

In a Canadian economic study of estrogen receptor positive breast cancers, switching from tamoxifen to the oral steroidal aromatase inhibitor exemestane (trade name: Aromasin) extended disease free survival at a minimal cost per person. In another of study of human epidermal growth factor receptor 2 (HER2)-positive breast cancer, the addition of the anti-HER2 receptor monoclonal antibody, trastuzumab (trade name: Herceptin), is projected to improve life expectancy at a relatively low cost.

Breast cancer is a major cause of cancer mortality, second only to lung cancer as a cause of cancer death in women. The five-year survival rate for localized breast cancer has increased from 80 percent in the 1950s to 98 percent today. Mammography has led to cancers being detected earlier, when early treatments may be more effective.

A greater understanding of the molecular biology of breast cancer has led to new post-surgical treatments, including hormone modulators and monoclonal antibodies. Many of these agents have led to decreased mortality and disease recurrence. As the therapeutic effectiveness of these drugs has been verified and is included in professional treatment guidelines, their cost-effectiveness is being investigated.

Cost-effectiveness is measured not just in life years (LY) gained but is adjusted also for the quality of life gained. This combination is expressed as a quality-adjusted life year (QALY). The ratio of cost to QALY is calculated to provide a quantitative estimate of the cost-effectiveness of a therapy.

A recent study showed that switching from tamoxifen to exemestane after two to three years of tamoxi fen significantly improves disease-free survival compared to tamoxifen alone. Ms. Nancy Risebrough from the HOPE Research Centre, Sunnybrook Health Sciences Centre in Toronto and Dr. Nicole Mittmann from the HOPE Research Centre at Sunnybrook Health Sciences Centre in Toronto and the University of Toronto and colleagues evaluated the cost-effectiveness of switching from tamoxifen to exemestane after two to three years.

The authors found that over 7.5 years, a tamoxifen-exemestane adjuvant protocol improved disease free survival (LY and QALY) at an additional cost of Can dollars2,889 per patient. The incremental cost-effectiveness ratio was calculated to be Can dollars24,185/QALY gained, well below a recognized threshold of Can dollars50,000/QALY gained.

Based on three-year follow-up of a recent clinical trial, the addition of trastuzumab to adjuvant chemotherapy treatment has been projected to improve significantly the long-term survival of early HER2-positive breast cancers. Dr. Louis Garrison, Jr of the University of Washington in Seattle and co-investigators evaluated the cost-effectiveness of adding trastuzumab to standard chemotherapy.

Dr. Garrison and co-authors estimated that life expectancy would improve by three years on average with the addition of this drug due to reduced disease recurrence. Over a lifetime, the cost-effectiveness ratio was estimated to be US26,417/QALY dollars and over 20 years was estimated at US 34,201 dollars.

The two economic studies agree with previous cost-effectiveness studies of the similar regimens and support their clinical use. The cost-effectiveness ratios calculated for both exemestane and trastuzumab were below those of many widely used oncology treatments.


'"/>




Related medicine news :

1. Cost-effective antibiotics for sinusitis treatment
2. Cost-effective Meningitis Vaccine To Be Launched In Africa
3. Lowering Contrast Material Injection in Aged Patients is Cost-effective and can Offset Risks
4. Prevention (Of AIDS) By Circumcision More Cost-effective Than Cure
5. One-time Melanoma Screening Appears to Be Cost-effective for Elderly People
6. Need for Cost-effective Hearing Implants
7. New Adjuvant Breast Cancer Treatments Found Cost-effective
8. Now, FISH on a Chip for Quicker, Cost-effective Cancer Diagnosis
9. New Gene Identification Help Asthma Treatments
10. Comparing Psoriasis Treatments
11. Effectiveness Of Infertility Treatments Questioned
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2016)... ... February 13, 2016 , ... With FCPX Overlay Embers from Pixel Film Studios ... Cut Pro X. Each user can select from up to 40 effect overlays. With ... focus offset, hue, saturation, value, contrast, glow, and more all within a click of ...
(Date:2/13/2016)... ... February 13, 2016 , ... In the early or “honeymoon” ... themselves to perfection, go out of their way to be romantic, and may exaggerate ... a look at any online dating profile. , A recent study from ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... initiative—the Siemens Foundation-PATH Ingenuity Fellowships—to develop the advanced skills needed to introduce ... from U.S. universities who will draw from Siemens’ deep knowledge of product ...
(Date:2/12/2016)... ... February 12, 2016 , ... As a former television ... a demanding job, and no time to decompress, Rabinowitz found herself drawn to a ... meditation for its impact on her life, implementing a 20-minute-per-day meditation practice with her ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Every winter, someone ... This winter the West Penn Burn Center, part of the Allegheny Health ... to bring you the “Space Heaters Need Space” campaign. , “Space ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... SEOUL, South Korea , Feb. 12, 2016 ... today announced they will form a partnership to ... medicine in cancer. The goal of the collaboration ... with Macrogen,s high-throughput Next Generation Sequencing capabilities toward ... Laboratory Improvement Amendments (CLIA) of 1988 by the ...
(Date:2/12/2016)... 2016  Apellis Pharmaceuticals, Inc., today announced ... Series D preferred stock financing, co-led by ... Group and venBio Global Strategic Fund, joining ... Investment, and Epidarex Capital. The proceeds of the ... clinical trials in the Company,s ongoing complement ...
(Date:2/11/2016)... 2016 Stem cells are primitive cells found ... and the capacity to differentiate into mature cell types ... the first mouse embryonic stem cells were derived from ... that the first culturing of embryonic stem cells from ... produced until 2006 As a result of these discoveries, ...
Breaking Medicine Technology: