Navigation Links
Correlation Between Bile Duct Obstruction and Ductal Cancer Found

When bile duct cancer cells were placed in the liver of animals with bile duct obstruction, they grew more rapidly than identical cells placed in animals without bile duct// obstruction. In fact, half of the total liver mass of the rats with bile duct obstruction became replaced by cancer cells within three weeks compared to only 16 percent of that of animals without bile duct obstruction.

Perhaps even more important, the cancers metastized outside the liver (as they frequently do in human patients with advanced bile duct cancer) only in the animals with bile duct obstruction.

Virginia Commonwealth University scientist Dr. Alphonse Sirica presented the findings at Experimental Biology 2007 in Washington, DC.

The bile ducts are tubes that carry bile (a liquid secreted by the liver that contains cholesterol, bile salts, and waste products) from the liver to the gallbladder and small intestine. Bile duct obstruction has long been known to be present in both malignant and nonmalignant liver disease (jaundice, for example), but before the study by Dr. Sirica and his colleagues the direct effect of such obstruction on bile duct cancer cell growth and aggressiveness had not been previously investigated.

These new findings are highly significant for two reasons, says Dr. Sirica.

First, they establish an important correlation between bile duct obstruction and bile duct cancer, suggesting growth regulatory mechanisms that could be highly significant in the progression of the cancer and that could become good molecular targets for drug therapy.

Second, they establish a unique preclinical model of how bile duct cancer in liver progresses that can be used to rapidly test and evaluate novel molecular treatment strategies.

Such strategies are badly needed for this understudied cancer, adds Dr. Sirica. The incidence and mortality of cholangiocarcinoma, the primary cancer of the bile ducts, is i ncreasing worldwide. Some 3,500 new cases are now diagnosed annually in the United States. Survival rates remain dismally low because most patients have advanced disease at the time of diagnosis and thus are poor candidates for the current best treatment, surgical resection. Although there are some known risk factors for the disease (such as primary sclerosing cholangitis), the cause of most cases remain unknown and the cellular and molecular changes that accompany the disease have not been well understood.

Source-Eurekalert/V
'"/>




Related medicine news :

1. Link Between Infection And Heart Disease
2. Prescription Drug Use Varies Widely Between States
3. Wait Between Pregnancies
4. Link Between Migraines and Behavioral Disorders
5. Link Between Obesity and Behavior in Kids
6. Link Between Mothers Depression and Violence in Children
7. Link Between Alcohol and Decrease in Brain Size
8. Link Between Musculoskeletal Pain and Vitamin D Deficiency
9. Link Between Hyperglycemia & Hospital Mortality
10. Link Between Alcohol Consumption And Cardiovascular Disease
11. Understanding The Link Between Hormone Replacement and Respiratory Disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... ... March 24, 2017 , ... Gastro Health ... to prep patients for colonoscopy at the HyGIeaCare® Center that is to be ... FL. , The HyGIeaCare® Prep, cleared by the U.S. Food and ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... first Certified Medical Reiki™ Master in Frederick, MD. Judy says, “I am passionate ... during what is often a very difficult and challenging time.” , A Certified ...
(Date:3/24/2017)... ... ... Time GPS”: a dauntless and enlightened study of the second-coming of Christ, and ... published author, Wesley Gerboth, a World War II veteran, with a highly-regarded reputation as ... ninety-one, he shares the Wisdom God bestowed upon him in this publication. , ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... of inspiring stories about real people of God in congregations across the United ... Miller, a Presbyterian minister ordained in 1964 who has served congregations in seven ...
(Date:3/23/2017)... Greensboro, NC & Seattle, WA (PRWEB) , ... March 23, 2017 ... ... international public health emergency and now estimates that there could be four million Zika-related ... fastest growing epidemics to date with numbers of US cases reported per year skyrocketing ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Mar. 24, 2017 Research and Markets ... the U.S.: Consumer Strategies" report to their offering. ... Pain ... approach and treat their physical pain, emphasizing consumer survey analysis, ... pain sufferers and adults who have selected illnesses/conditions strongly associated ...
(Date:3/24/2017)... March 24, 2017 ShangPharma, a ... and cost-effective drug development and discovery services, ... biotechnology industry, announced today the intent for ... will be consolidating the Contract Research Organizations ... Shanghai ChemPartner. These entities include ChemPartner Shanghai, ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... offering. ... is very strong with a total of 97 drug candidates. Pharma giant ... are involved in the development of the IPF therapeutics. The IPF pipeline ... stage, 15 are in Phase II stage, 12 are in Phase I ...
Breaking Medicine Technology: