Navigation Links
Computational Model Reveals Working of AZT in Body

A computational model has been developed by researchers at the Virginia Bioinformatics Institute (VBI) at Virginia Tech which would allow scientists to have a better //understanding of the metabolism and toxicity of the HIV/AIDS drug zidovudine (azidothymidine, AZT).

AZT is used successfully as part of Highly Active Anti-Retroviral Therapy (HAART) to control the level of the human immunodeficiency virus in HIV-infected individuals. However, long-term use of AZT may lead to side-effects in some patients. David Samuels and coworkers are interested in finding out whether the toxic side effects of AZT can eventually be minimized or even eliminated. For this purpose, they have been developing a detailed computational model that allows scientists to simulate the biochemical reactions that take place when AZT is metabolized in cells, including their mitochondria, under different metabolic conditions. Drugs like AZT may interfere with DNA replication in the mitochondria, the energy factories of our cells, and can lead to potentially fatal side effects in patients undergoing HAART treatment.

Samuels, assistant professor at VBI, commented: "HAART is one of the biggest success stories in modern medicine. The goal of our work is to help improve this successful treatment by understanding the toxic effects that AZT can have in some people. There are many different ways that AZT could possibly interfere with mitochondria to cause the toxic side-effects. Our job is to model these proposed toxicity mechanisms to see which ones could actually lead to the mitochondrial defects found in AIDS patients." He added: "It is possible that no single mechanism is responsible for the toxicity, but that instead a combination of multiple effects is needed. That is the kind of problem that needs a systems biology approach."

When AZT reaches a cell, it is subject to some of the same metabolic modifications or phosphorylation events that are encountered by the four natu
'"/>




Page: 1 2

Related medicine news :

1. Researchers Develop Mouse Model Of Brain Tumor
2. New Model for understanding Tumor Metastasis
3. Mathematical Model Can Now Help Predict Asthma Risk
4. Model Kate Moss - Re-Birth After Humiliation
5. Womens Self-Esteem Not Lowered By Seeing Ultra Thin Models
6. India Can Become A Role Model In Combating HIV Infections
7. Mouse Models To Determine The Cause Of Aggressive Leukemia
8. Aussie Model Macpherson Hated Tall Figure
9. Mouse Model Beneficial to Study of Head and Neck Cancer
10. Tamil Nadu Emerging As Model State In Public Health Care: Governor
11. iSTART Brain Model Reveals the possible Cause of Autism
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Computational Model Reveals Working AZT Body

(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... risk of death and heart attack can be reduced for ... the usual dose of an anti-clotting drug before the procedure ... a balloon-tipped catheter is threaded into an artery. The balloon ... the vessel. A small synthetic tube - stent is used ...
... It has been found out that there is no association ... food -- and breast cancer. More than 43,000 women were ... participants had their average daily intake of acrylamide monitored. No ... women whose intake was higher was documented. Acrylamide was first ...
... Session of the International Association for Dental Research held ... of a study// that says eating sugar-free yogurt is ... bad odor or so called bad breath is caused ... The study revealed that volunteers who had sugar-free more ...
... has found out that depression has to be blamed for ... to treat the same. The study was conducted on 60,000 ... results showed both the newer and older classes of antidepressants ... first month of being prescribed.The older class of tricyclic antidepressants ...
... of the drug tezosentan did not improve worsening heart failure ... despite high hopes. The above fact was found out in ... The study was conducted to evaluate if something more could ... speed up hospital discharge and prevent them from coming back. ...
... known to help in controlling obesity. A new study coming ... (2005) says that dietary calcium present in the yogurt has ... lipid utilization and decrease in lipogenesis. ,The ... group was put on balanced deficit diets and the other ...
Cached Medicine News:
(Date:12/24/2014)... , December 24, 2014 ... Report on Global Disposable Syringe Industry of ... its online business intelligence library. ... Disposable Syringe Industry is a professional and ... market.  For overview analysis, the report introduces ...
(Date:12/24/2014)... ALEXANDRIA, Va. , Dec. 23, 2014 /PRNewswire-USNewswire/ ... stringent diastolic blood pressure target for people with ... either moderate or high doses of statins, in ... risk management enacted by the American College of ... recommendations are reflected in the most recent changes ...
(Date:12/24/2014)... HILL, N.C. , Dec. 23, 2014  Medical ... success. As the key link between the medical device ... grow even more in the coming years as the ... According to research by benchmarking firm, ... MSLs can gain an important edge is by harnessing ...
Breaking Medicine Technology:World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4Role of Medical Science Liaisons Evolving in Medical Device Sector 2
... CorMatrix® Cardiovascular, a medical device company dedicated to developing ... body,s innate ability to repair damaged cardiovascular tissue, announced today it ... Repair. With this designation, CorMatrix is now able to market this ... , , ...
... Company (Nasdaq: PRGO;TASE) today announced that Perrigo Executive Vice President and CFO ... Global Healthcare Conference on Tuesday, June 15 , at 3:05 ... Los Angeles .  The presentation will be webcast on the following link: ... , Perrigo ...
Cached Medicine Technology:CorMatrix(R) ECM(TM) Receives CE Mark for Cardiac Tissue Repair 2
... has the right product for any patient ... intubated patients to patients with tracheotomies. These ... and critical care applications., ,The Unti-Mist ... patients and staff members. This entire product ...
Bacterial/Viral Filters for Anesthesia and Respiratory Applications...
Ballard trach care HMES and filters, universal use, "Y" filter, CO 2 sampling port...
Indications For Usage: ,Single patient use on anesthetized patients and respiratory care patients who require a breathing circuit. The product is intended to be replaced at least once every 24 hours...
Medicine Products: