Navigation Links
Compound Present in Plant may Help to Curb Craving for Cannabis

An experiment on mice conducted by US scientists has shown that a compound extracted from a plant from the buttercup family has the ability to reduce craving for marihuana, and block its effect on the brain.

Steven Goldberg of the Maryland based National Institute on Drug Abuse found that upon administration of the plant extract, the rodents lose their hankering for a synthetic version of tetrahydrocannabinol (THC), an active compound in marijuana. The treatment also blocked a reward response in the animals' brains when they did receive synthetic THC.

During the course of study, the rats were placed in a cage with a lever that they could push. As and when they leaned on the lever, they received a dose of the synthetic THC through a small tube running into their body.

It was observed that over a period of three weeks, the rats learnt how to enjoy the effects of synthetic THC, and frequently administered themselves the drug. But the animals who received saline solution did not press the lever often.

Goldberg then injected the rats with methyllycaconitine (MLA), a compound derived from the seeds of the Delphinium brownii plant, and noted that it had a dramatic effect on the rats behaviour, viz, reduction in the pushing of lever for synthetic drug THC by 70 per cent.

According to the researchers, he drug did not seem to otherwise change the rats' movement and co-ordination, and had no other apparent side effects.

Researchers also checked the effects of the plant extract on the rats' brains through a technique called microdialysis. They had a close look at the tiny fluid samples from a reward-signalling area of the brain known as the nucleus accumbens, which sits near the base of the head.

When rats receive synthetic THC, levels of the reward chemical dopamine normally shoot up in the nucleus accumbens, but the plant extract blocked the release of dopamine in this brain re gion.

"The increases in dopamine are virtually non-existent because of MLA," the New Scientist quoted Goldberg as saying.

The scientists, however, are clueless as to the mechanism by which MLA works.

Goldberg also stressed the need for developing medications that may help cannabis addicts overcome their drug problem, and is of the opinion that more options, such as one based on MLA, must be explored.

"Each patient is different and what works in one might not work in another," said the researcher.


'"/>




Related medicine news :

1. Compound of Broccoli combats breast cancer
2. New Compound Could Strengthen The Effect Of Chemotherapy
3. Breathing Cancer Causing Compounds During Pregnancy Found To Affect Offspring
4. Compound from cottonseed for neck and head cancers
5. Compounds Found In The Vegetable Broccoli Could Have Anti-Cancer Properties
6. Adding Sorghum Compounds To Dietary Supplements May Help Lower Cholesterol
7. Compound In Grapes And Red Wine To Counter Alzheimers Disease
8. Sugars Could Contain Key Cancer Inhibiting Compounds
9. Compound From Cyanobacterium Can Fight Alzheimer’
10. Five New Anti-Inflammatory Compounds Produced By Indian Scientists
11. Compounds in Licorice Can Fight Tooth Decay
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/17/2017)... ... January 17, 2017 , ... Surgeons ... to primary eye care practitioners on the latest breakthroughs in the prevention, diagnosis ... Continuing Education Symposium, according to eye surgeon, Jeffrey Martin, MD, FACS, Chief Executive ...
(Date:1/17/2017)... ... 17, 2017 , ... Neil H. Greco Insurance Agency, a northern New Jersey ... region, is launching a charity drive to raise awareness of heart disease and promote ... in America, and is responsible for 1 in every 4 deaths at the national ...
(Date:1/17/2017)... ... 2017 , ... Livionex, Inc., a Silicon Valley healthcare company focused on treating ... its dental gel that shows significant reduction in plaque levels and gum inflammation and ... was conducted at the Beckman Laser Institute at UC Irvine and has been published ...
(Date:1/17/2017)... ... 17, 2017 , ... The Sharie Withers Agency, a full-service ... latest beneficiary of their thriving community involvement program. The current campaign fundraises to ... dreams of terminally ill patients. Donations to this worthy cause may now be ...
(Date:1/17/2017)... ... January 17, 2017 , ... Today, FloSports , a global ... a new agreement as part of a long-term extension of their media partnership. The ... airing of some of the sport’s premier events exclusively on FloWrestling.com as well as ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... -- Interpace Diagnostics Group, Inc., (NASDAQ: IDXG ), ... and pathology services for evaluating risks of cancer, announced ... 13, 2017 from the NASDAQ Listing Qualifications notifying the ... of the NASDAQ Stock Market to maintain a minimum ... The letter noted that for the last 10 days ...
(Date:1/17/2017)... Research and Markets has announced the addition ... their offering. ... The global laparotomy sponges market to grow at a CAGR of ... Sponges Market 2016-2020, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
(Date:1/17/2017)... , Jan. 17, 2017 Tempus, ... cancer care, and University Hospitals Seidman Cancer Center ... by making genomic data, advanced molecular analysis and ... researchers, physicians and healthcare providers. ... provide genomic and transcriptomic sequencing and analysis for ...
Breaking Medicine Technology: