Navigation Links
Compound Present in Plant may Help to Curb Craving for Cannabis

An experiment on mice conducted by US scientists has shown that a compound extracted from a plant from the buttercup family has the ability to reduce craving for marihuana, and block its effect on the brain.

Steven Goldberg of the Maryland based National Institute on Drug Abuse found that upon administration of the plant extract, the rodents lose their hankering for a synthetic version of tetrahydrocannabinol (THC), an active compound in marijuana. The treatment also blocked a reward response in the animals' brains when they did receive synthetic THC.

During the course of study, the rats were placed in a cage with a lever that they could push. As and when they leaned on the lever, they received a dose of the synthetic THC through a small tube running into their body.

It was observed that over a period of three weeks, the rats learnt how to enjoy the effects of synthetic THC, and frequently administered themselves the drug. But the animals who received saline solution did not press the lever often.

Goldberg then injected the rats with methyllycaconitine (MLA), a compound derived from the seeds of the Delphinium brownii plant, and noted that it had a dramatic effect on the rats behaviour, viz, reduction in the pushing of lever for synthetic drug THC by 70 per cent.

According to the researchers, he drug did not seem to otherwise change the rats' movement and co-ordination, and had no other apparent side effects.

Researchers also checked the effects of the plant extract on the rats' brains through a technique called microdialysis. They had a close look at the tiny fluid samples from a reward-signalling area of the brain known as the nucleus accumbens, which sits near the base of the head.

When rats receive synthetic THC, levels of the reward chemical dopamine normally shoot up in the nucleus accumbens, but the plant extract blocked the release of dopamine in this brain re gion.

"The increases in dopamine are virtually non-existent because of MLA," the New Scientist quoted Goldberg as saying.

The scientists, however, are clueless as to the mechanism by which MLA works.

Goldberg also stressed the need for developing medications that may help cannabis addicts overcome their drug problem, and is of the opinion that more options, such as one based on MLA, must be explored.

"Each patient is different and what works in one might not work in another," said the researcher.


'"/>




Related medicine news :

1. Compound of Broccoli combats breast cancer
2. New Compound Could Strengthen The Effect Of Chemotherapy
3. Breathing Cancer Causing Compounds During Pregnancy Found To Affect Offspring
4. Compound from cottonseed for neck and head cancers
5. Compounds Found In The Vegetable Broccoli Could Have Anti-Cancer Properties
6. Adding Sorghum Compounds To Dietary Supplements May Help Lower Cholesterol
7. Compound In Grapes And Red Wine To Counter Alzheimers Disease
8. Sugars Could Contain Key Cancer Inhibiting Compounds
9. Compound From Cyanobacterium Can Fight Alzheimer’
10. Five New Anti-Inflammatory Compounds Produced By Indian Scientists
11. Compounds in Licorice Can Fight Tooth Decay
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... PLAINSBORO, N.J. (PRWEB) , ... June 27, 2016 , ... ... same sources, yet in many ways they remain in the eye of the beholder, ... Oncology (EBO), a publication of The American Journal of Managed Care. For the full ...
(Date:6/26/2016)... California (PRWEB) , ... June 26, 2016 , ... Pixel ... Cut Pro X. , "Film editors can give their videos a whole new perspective ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over ...
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... ... ... Bruton Memorial Library on June 21 due to a possible lice infestation, as reported by ... lice: the parasite’s ability to live away from a human host, and to infest common ... the event that lice have simply gotten out of control. , As lice are a ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Va. , June 24, 2016 The ... set of recommendations that would allow biopharmaceutical ... (HCEI) with entities that make formulary and coverage decisions, ... the "value" of new medicines. The recommendations ... does not appear on the drug label, a prohibition ...
(Date:6/24/2016)... June 24, 2016 According to ... Type (Standard Pen Needles, Safety Pen Needles), Needle Length ... Growth Hormone), Mode of Purchase (Retail, Non-Retail) - Trends ... report studies the market for the forecast period of ... USD 2.81 Billion by 2021 from USD 1.65 Billion ...
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
Breaking Medicine Technology: