Navigation Links
Completely Neutral Evolutionary Changes Helped Shape Our Genome

e and rats only have around 600 numts. Since they increase in frequency as species advance, it suggested there was some evolutionary purpose to keeping them around.

Strikingly, however, none of these numts contained the blueprint (an actual gene) to make a protein that does anything, nor did they seem to control the function of any nearby genes.

"At best, it seems numts are a neutral part of our genome. If anything, they may be mildly negative since long repeat sequences can be unstable or get inserted inside genes and disrupt them," said Katsanis.

The researchers believe they have uncovered a possible reason why these potentially damaging but mostly neutral bits of DNA accumulate over time by comparing the sequences of human numts with those in different animals. How closely the different species' sequences match can provide an estimate of when that particular sequence got inserted into the ancestor of the human genome.

Their calculations revealed that most numts became embedded in our genome over a 10-million-year period centered roughly 54 million years ago - right around the time when the first primates emerged.

"When new species emerge, their numbers and therefore their genetic differences are very small. This creates a genetic bottleneck during which any changes in the genome will either get eliminated quickly or spread to the whole population quickly," Katsanis notes.

Katsanis proposes that numts, being "neutral," were generally at low levels in ancient mammals, but during the primate emergence 54 million years ago, they accumulated and spread through the small early primate populations precisely because they were not detrimental enough to be eliminated. Then, as these populations expanded, numts reached stable but higher frequencies.

The study is published online in PLoS Genetics.


'"/>




Page: 1 2

Related medicine news :

1. Further Studies Needed To Completely Understand About Ventricular Fibrillation
2. Flu Vaccines Expected to Meet Needs Completely
3. GlaxoSmithKline - Changes Lamictal(R) Label Appearance and Packaging
4. Changes in cabin pressure pose risks for moms-to-be
5. Dietary Changes Could Reduce The Risk for Stroke
6. Link Between High Blood Sugar And Behavioral Changes
7. Specific Changes In A Particular Gene Found To Increase The Risk of Alzheimer’s Diseas
8. Ultrasounds To Detect Changes In Heart Motions
9. Changes In Brain Structure From Methamphetamine Abuse And HIV Infection
10. Age Can Changes Symptoms Of Sinusitis
11. New Research To Study Brain Changes In Premature Births
Post Your Comments:
(Date:12/26/2014)... 26, 2014 It is said that nothing ... Today, UWDress.com, the famous wedding dress supplier, shows its ... site-wide cocktail gown promotion. , UWDress.com’s navy cocktail gowns ... they come in high fashion styles. Simple dresses in bright ... the occasion; they are specially designed for those who want ...
(Date:12/26/2014)... Yisrayl Hawkins, Pastor at The House of Yahweh in Abilene, ... Ferguson, Missouri unrest. Yisrayl starts his letter by showing the ... has only increased. , He continues in his letter ... is a very specific reason for mankind and covers those ... of rules, or Laws that if followed would ensure that ...
(Date:12/26/2014)... (PRWEB) December 26, 2014 Plugin and template ... TransPack Volume 5 Plugin for Final Cut Pro X. , ... hard light tool to pull off an industry professional look” ... get their hands on TransPack Volume 5, a new level ... is a set of over 50 Final Cut Pro X ...
(Date:12/26/2014)... India Network Foundation, a non-profit US ... announced today a new version of “ EasySelect ”, ... right plan for their visiting parents. The technology tool ... selection process when choosing an insurance plan by showing ... a few clicks. Many elderly Asian Indian parents often ...
(Date:12/26/2014)... 26, 2014 DW-InductionHeating.com (DaWei Induction Heating ... researching and developing, producing and marketing of a series ... business announces their new series of induction brazing ... the company, induction brazing refers to the ... filler material and heat. The manager says that there ...
Breaking Medicine News(10 mins):Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2Health News:Yisrayl Hawkins Pleads for Peace in Ferguson and Beyond in New Open Letter 2Health News:Today a new plugin was announced from Pixel Film Studios, TransPack Volume 5 for Final Cut Pro X 2Health News:India Network Health Insurance Announces new Comprehensive Pre-existing Condition Coverage policy for Visitors to the United States 2Health News:India Network Health Insurance Announces new Comprehensive Pre-existing Condition Coverage policy for Visitors to the United States 3Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2
... The American Society for Radiation Oncology (ASTRO) has ... use of stereotactic body radiotherapy (SBRT) in lung ... treatment that uses focused radiation beams to target ... computerized three-dimensional treatment planning and precise treatment setup ...
... 28, 2010 In a major crackdown, Cambodia has ... the country to close within the past five months. ... & Substandard Medicines (IMC), the shops were targeted because ... of substandard and counterfeit medicines in the country. This ...
... protein might help humans with fractures, too , WEDNESDAY, April ... to significantly speed up the healing of broken bones in ... people with fractures would be free of their casts a ... Victor Khabie, co-director of the Orthopedic and Spine Institute at ...
... ... ... to pay $520 million in civil fines, penalties and damages to settle allegations that ... its marketing and promotional practices for the blockbuster atypical antipsychotic Seroquel (U.S. ex rel. ...
... study refutes link between intensive therapy, higher death risk , ... Cardiovascular Risk in Diabetes (ACCORD) study was abruptly halted in ... group of type 2 diabetics who were being intensively treated ... , Now, a new analysis of data from that ...
... 28 April 2010 Patients recovering from stroke sometimes behave ... colliding with obstacles on their left, eating food only from ... their left side. This puzzling phenomenon is termed "spatial neglect" ... stroke in the right side of the brain. The condition ...
Cached Medicine News:Health News:Cambodia takes action in fight against substandard and counterfeit medicines 2Health News:Cambodia takes action in fight against substandard and counterfeit medicines 3Health News:Scientists Find Way to Heal Broken Bones Faster 2Health News:Scientists Find Way to Heal Broken Bones Faster 3Health News:AstraZeneca Pays $520 Million to Settle Seroquel Whistleblower Claims 2Health News:AstraZeneca Pays $520 Million to Settle Seroquel Whistleblower Claims 3Health News:Tight Blood Sugar Control May Not Harm Diabetics 2Health News:Tight Blood Sugar Control May Not Harm Diabetics 3Health News:Lottery game helps to assess brain damage following stroke 2
(Date:12/24/2014)... N.J. and FARMINGTON, Conn. ... Technologies, Inc. (NYSE MKT: PTN), a biopharmaceutical company ... of diseases with significant unmet medical need and ... on a private placement of 2,050,000 shares of ... purchase 24,949,325 shares of its common stock.  Funds ...
(Date:12/24/2014)... Dec. 23, 2014 Echo Therapeutics, Inc. ... company focused on skin permeation, continuous glucose monitoring ... W. Hollander has been appointed Chief Executive ... more than 20 years of experience in the ... most recently served as Vice President, Business Development, ...
(Date:12/24/2014)... December 24, 2014 ... Global Disposable Syringe Industry of 178 pages ... business intelligence library. The 2014 ... Industry is a professional and deep research ... overview analysis, the report introduces Disposable Syringe ...
Breaking Medicine Technology:Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5
... Incorporated (Nasdaq: ARAY ), a global ... Senior Vice President, General Counsel and Corporate Secretary, Darren ... by the Silicon Valley/San Jose Business Journal and ... their ,Best Bay Area Corporate Counsel Awards,. This annual awards ...
... 25, 2011 Landauer, Inc. (NYSE: LDR ... quarterly cash dividend of $0.55 per share for the second quarter ... 2011, to shareholders of record on March 11, 2011. ... provider of technical and analytical services to determine occupational and environmental ...
Cached Medicine Technology:Accuray's General Counsel Wins Best Bay Area Corporate Counsel Award 2Accuray's General Counsel Wins Best Bay Area Corporate Counsel Award 3Accuray's General Counsel Wins Best Bay Area Corporate Counsel Award 4
... Plate Shaker with Timer are designed to give ... & 384-well microplates. The on/off button, power supply ... the side of the unit. The speed knob ... for adjustment of speed from a minimum 950 ...
Microplate incubator shaker used in a variety of immunoassay and research procedures requiring microplates....
Multiparameter laser and arc lamp flow cytometer for all applications in immunology, microbiology, cell biology, pathology, hematology, lymphocyte dubset and cell analysis....
This unique system combines the analytical power of a research cytometer into a compact, truly walk away, clinical analyzer ergonomically designed to expedite sample throughput....
Medicine Products: