( duction of cells used to build blood ve...)Common Pain Killer may Reduce the Risk of Brain Damage in Premature Babies,Health

duction of cells used to build blood vessels, and decreased levels of angiopoietin-2 and VEGF, the two molecules very active in building new blood vessels.

Results were spectacular in female rabbits that were given the drugs for two days before delivering their offspring prematurely. The team showed that celecoxib cut the risk in offspring of having a moderate or severe bleed in half, from 90 percent to 45 percent. The percentage was reduced even more when ZD6474 was used as well, from 45 to 27 percent, but Nedergaard and Ballabh indicate that ZD6474 is a very powerful medication not likely to be given to pregnant women in the near future.

On the whole, the best way to thwart the problem, doctors say, is to do everything possible to allow a pregnant woman to bear a pregnancy for a full 40 weeks. So doctors put a great deal of effort into preventing preterm labor. But when premature labor can't be prevented, doctors do have a few tools at their disposal to try and prevent bleeds in the germinal matrix.

"This work is very exciting, but the work is ongoing, and we must investigate the use of celecoxib more thoroughly before considering it for widespread use to prevent this problem," said Ballabh. "We can fix many problems in the premature infant, but brain damage is one problem that cannot be fixed it must be prevented. Right now there is nothing available that has been shown to be really effective at preventing this problem."


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