Navigation Links
Combining NSAIDs With Chemotherapy May Improve Cancer Therapy

Until recently, nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin and celecoxib (sold as Celebrex), were being hailed as promising cancer prevention drugs . However, the latest studies have concluded that in most cases the adverse side effect of these drugs -- including risk of cardiovascular and kidney disease -- outweigh the potential benefit.

However, certain NSAIDs may be better suited to treating cancer, in combination with standard therapies, rather than preventing it, according to new research by scientists at the University of Iowa Roy J. and Lucille A. Carver College of Medicine.

"The real debate comes down to use of these compounds in two settings: cancer prevention, which involves long-term use of a drug, and cancer treatment involving short-term, focused use of the drug," said Douglas Trask, M.D., Ph.D., UI associate professor of otolaryngology head and neck surgery. "Published studies show that heart and kidney problems occur with long-term use, especially when used for more than one year. While there appear to be cardiorenal effects of NSAIDs even with short-term use, these risks may be minor compared to the potential benefit to treat cancer more effectively."

Two new UI studies show that the NSAID celecoxib has potent anticancer activity, which is associated with the drug's ability to disrupt the cell cycle -- the orderly, multi-step process by which cells divide.

In particular, the experiments showed that celecoxib specifically kills head and neck cancer cells in the S phase of the cell cycle, where the cell synthesizes new DNA and replicates its genetic material.

"The finding that the cell killing effect takes place in S phase is particularly exciting because one of the standard therapies for most cancers -- chemotherapy -- often has its maximal effect at that stage of the cell cycle," Trask said. "We're hopeful that our results will lead to a clinical trial where we
'"/>




Page: 1 2 3

Related medicine news :

1. Tamiflu Shortage Can Be Better Handled By Combining It With Probenecid
2. Combining Therapies can Improve Survival for Early-stage Breast Cancer Patients
3. The Effectiveness Of NSAIDs Evaluated
4. NSAIDs In First trimester Linked To Congenital Anomalies In Babies
5. Study Explains How NSAIDs Halt Cancer Growth
6. Aspirin Or NSAIDs Will not Prevent Colorectal Cancer
7. Acupuncture May Help Chemotherapy Side Effects
8. Chemotherapy Pill Has Fewer Side Effects Than IV
9. Survival rates in breast cancer patients improved with "Dose Dense Chemotherapy"
10. Therapy Boosts Chemotherapy Effects
11. Chemotherapy Effective for Bladder Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Combining NSAIDs With Chemotherapy May Improve Cancer Therapy

(Date:9/1/2015)... ... September 01, 2015 , ... Discovia, a leading ... today that it has hired Scott Sanderson, an experienced business development professional and ... will be responsible for establishing and managing new client relationships in the Southeast ...
(Date:9/1/2015)... ... September 01, 2015 , ... WorkCare, Inc., a ... its medical management team as an Associate Medical Director. , WorkCare specializes ... in the U.S. and abroad. , Dr. Nelson has a diverse background. ...
(Date:9/1/2015)... ... September 01, 2015 , ... SC&H Group, a leading ... includes being named a “Best of the Best” firm in the U.S., as well ... the “Best of the Best” in the U.S., selected exclusively on performance in specific ...
(Date:9/1/2015)... ... ... Mercy Health (formerly Catholic Health Partners) – a Catholic healthcare ministry serving Ohio ... Be Well videos to prostate cancer awareness. Prostate cancer is the most-common, non-skin cancer ... Mercy Health’s YouTube channel, Mercy Health experts address issues, such as:, ...
(Date:9/1/2015)... FL (PRWEB) , ... September 01, 2015 , ... ... discount cards, launched its consumer-friendly, informational video this week to coincide with back-to-school ... http://www.USAMedicalCard.com/video . , According to the CDC, elementary school children are sick ...
Breaking Medicine News(10 mins):Health News:Former NFL Standout Scott Sanderson Joins eDiscovery Leader Discovia 2Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 2Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 3Health News:SC&H Group Receives Multiple Honors from INSIDE Public Accounting 2Health News:New Mercy Health Video Explains Most-Common Cancer Found in Men 2Health News:USA Medical Card Launches New FAQ Video During Back-to-School 2
... ... Tea Party Support ( http://teapartysupport.com ) and the Social Security Institute ... necessary, including the use of any parliamentary device available to them, ... ,Rush Limbaugh questioned Senate Minority Leader McConnell’s strategy a few times ...
... , HONG KONG, Dec. 11 /PRNewswire-Asia-FirstCall/ -- ... ), China,s leading provider of,cord blood collection, laboratory testing, hematopoietic stem ... for the quarter and six months ended September 30, 2009. , ... -- For the quarter ended September 30, 2009, net ...
... Ore.) More than 10 percent of women of Chinese ... during pregnancy, according to a Kaiser Permanente study of 16,000 ... the Ethnicity and Disease journal. The study also ... one-third higher than averageand more than double that of Caucasian ...
... ... services , ... December 11, 2009 -- Therapure Biopharma Inc. today announced the signing of an exclusive ... development initiatives. , , ,Under the terms of the partnership, Therapure Biopharma will provide ...
... ... other firms to form "Dream Team" of plaintiffs, attorneys handling defective construction litigation ... Ocean Spring, Miss. ... law firm that represents plaintiffs in a wide range of personal injury, construction defect, ...
... , WASHINGTON, Dec. 10 The following ... for Tobacco-Free Kids: , (Logo: http://www.newscom.com/cgi-bin/prnh/20080918/CFTFKLOGO ) ... for health and the public,s right to breathe clean ... including all restaurants and bars, smoke-free. Gov. Jennifer Granholm ...
Cached Medicine News:Health News:Rush Limbaugh & Michael Steele Join Tea Party Support & Social Security Institute-Demand GOP Senate Stop ObamaCare by Any Means Possible 2Health News:Rush Limbaugh & Michael Steele Join Tea Party Support & Social Security Institute-Demand GOP Senate Stop ObamaCare by Any Means Possible 3Health News:China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009 2Health News:China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009 3Health News:China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009 4Health News:China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009 5Health News:China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009 6Health News:China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009 7Health News:China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009 8Health News:China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009 9Health News:China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009 10Health News:China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009 11Health News:China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009 12Health News:China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009 13Health News:China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009 14Health News:China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009 15Health News:China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009 16Health News:Chinese-American and Korean-American women at highest risk for diabetes in pregnancy 2Health News:Chinese-American and Korean-American women at highest risk for diabetes in pregnancy 3Health News:Therapure Biopharma Inc. and Akorn, Inc. Announce Strategic Supply Contract 2Health News:Luckey & Mullins Joins with Other National Construction Defect Law Firms to Form Chinese Drywall Legal Network 2Health News:Approval of Michigan Smoke-Free Legislation is Historic Win for Health 2Health News:Approval of Michigan Smoke-Free Legislation is Historic Win for Health 3
(Date:9/1/2015)... BerGenBio AS ("BerGenBio" or the ... has appointed Hilde Furberg and Dr ... of Directors, effective immediately. Hilde Furberg ... and biotech and is currently Senior Vice President Rare ... role was Vice President and General Manager of Nordic ...
(Date:8/31/2015)...  DICOM Grid,  the #1 medical image exchange ... as a semifinalist for a Minnie award for ... are sponsored by Auntminnie.com, a comprehensive community website ... imaging industry.  Since 1999, the "Minnies" have provided ... contributions of their peers. Nominations are made by ...
(Date:8/31/2015)... 2015 Thousands of people will peacefully demonstrate ... opioid addiction epidemic at dozens of rallies across the ... the United States has experienced ... opioids and heroin, yet the President has never once ... letter to President Obama , rally organizers compared ...
Breaking Medicine Technology:BerGenBio Appoints Non-Executive Directors 2DG Suite Nabs "Minnies" Nomination for "Best New Radiology Software" 2Obama Administration's Neglect of Opioid Crisis Prompts Rallies in Many States 2
The CH 2000 Cardiac Diagnostic system is a fully featured stress testing system that can include Microvolt T-Wave Alternans (MTWA) testing capability as an add-on feature. , ,Interfaces with Tra...
... The Volk G-1 trabeculum provides the highest ... Perfect for viewing and treating the trabecular meshwork. ... of the anterior chamber angle while the central ... view the posterior pole for signs of glaucoma ...
... AFX (Air Fluid eXchange) Lens ... designed for use in an ... its use as a primary ... low profile and sutureless design ...
... The 45° Prism is ... pathologies and are recommended ... (PDR, BRVO etc.) and ... can be used for ...
Medicine Products: