Navigation Links
Combined modality approach for effective treatment and enhanced survival in bile duct cancer

Hilar cholangiocarcinoma is a type of bile duct cancer. Conventional therapy for this for of cancer is to remove (resect) the tumor, which may require removing part of the liver. Survival for patients// with this type of operation is only 25 to 35 percent, and many patients cannot be treated this way because the tumors can involve both sides of the liver.

Cholangiocarcinoma is a relatively uncommon malignant tumor that is often found in the lining of the bile duct. The cancer also is seen in patients with congenital bile duct cysts and bile duct stones. Most frequently, these tumors are located near the liver. Cholangiocarcinomas in this location are difficult to treat because the tumor often extends deep into the liver in a way that it cannot be completely removed with a conventional operation.

A new approach that offers greater chance of survival by involving a combination of liver transplantation, radiotherapy and chemotherapy may be beneficial to these patients according to research.

The five-year survival rate for patients who received a liver transplant after radiation and chemotherapy was 82 percent, significantly higher than for those who had a conventional operation. “Patients with bile duct cancer now have a much better chance to live longer and enjoy a good quality of life," says Charles Rosen, surgeon and co-author of the study.

Transplantation enables surgeons to remove the entire liver and obtain better tumor clearance. Patients treated with transplantation have enjoyed a higher likelihood of prolonged survival than those treated with the conventional operation.

Patients receive high dose external beam radiation therapy, followed by high dose irradiation with iridium administered through a catheter passing through the bile duct and tumor. Chemotherapy starts during radiation treatment and continues until transplantation. Prior to transplantation, patients undergo a staging abdominal operation so surg eons can look for any spread of the tumor to lymph nodes or the abdomen that would prevent complete tumor removal.

"The major problem is that we still don't have enough livers for everyone who needs one," says Dr. Rosen. "We feel that patients with cholangiocarcinoma should have equal access to donor organs, because the results are comparable to those achieved for other patients who undergo transplantation. Without a transplant, the outlook for these patients is fairly poor."
'"/>




Related medicine news :

1. Combined scan gives exact cancer diagnosis
2. A Protein-Rich Diet Combined With Exercise Found To Be More Effective In Weight Loss
3. Vision Loss in Elderly Caused By Combined Effect of Genes and Bacterium
4. Exercise Combined with Dialysis Yields Better Results
5. Combined Anti-Fever Drug Therapy Proves Unsafe for Childhood Fever
6. A Combined Heart Pill-developed by Dr. Reddy’
7. A Combined Research for Producing Chlamydia Vaccine Begins
8. Combined Ingredients may Cut Cholesterol Levels
9. Combined Imaging Approach may Provide Better Identification of Difficult-to-diagnose Brain Clots
10. Combined Imaging Approach may Be Effective in Diagnosing Some Brain Clots
11. Fresh approach to TB treatment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/30/2016)... ... April 30, 2016 , ... ... Radio with Hypnotherapist, Mary O'Maley. What is hypnosis and hypnotherapy and why ... smoking, weight control), pain relief (chronic and acute), birthing processes and medical procedures, ...
(Date:4/30/2016)... ... 30, 2016 , ... Dr. Trevor Gardner, President of the ... a multifaceted agreement which will allow for the research and development of medical ... and Applied Sciences, Allied Health and Nursing will work together to develop new ...
(Date:4/30/2016)... ... 30, 2016 , ... Orlando-based Maximized Living has selected Dr. Nick Wilson of ... Under the care of Maximized Living doctors at the London Olympics in 2012, ... Living is sending the largest contingent of elite chiropractors to Rio to support and ...
(Date:4/29/2016)... ... April 29, 2016 , ... In an article ... shares her enthusiasm for Botox and lip injections, which she underwent in order to ... Coachella Valley Music and Arts Festival. The article explains that Ms. Mirmelli’s situation is ...
(Date:4/29/2016)... ... April 29, 2016 , ... Shamangelic Healing, Sedona Arizona's ... brand Alpha BRAIN and New Mood Daily-Stress Formula for brain optimization and wellness ... to the store is just one more way Shamangelic Healing supports people’s quest ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 ... development of innovative peptide and gene-based immunotherapeutics and vaccines for ... will be presenting at the 3rd Annual Growth Capital ... 5 th , 2016 at Caesars Palace in Las Vegas, Nevada.  ... am on Wednesday, May 4 th by Dr. ...
(Date:4/27/2016)... MARLBOROUGH, Mass., April 27, 2016  Hologic, Inc. ... Company,s financial results for the fiscal second quarter ... share (EPS) of $0.24 increased 41.2%, and non-GAAP ... $693.3 million increased 5.8% on a reported basis, ... "We posted another good quarter, highlighted ...
(Date:4/27/2016)...   , ... le trimestre, soutenu par une croissance de +42% ... de +16% des ventes aux hôpitaux et cliniques  ... (Euronext : MKEA, FR0010609263 ; OTCQX : MKEAY), inventeur de Cellvizio®, ... chiffre d,affaires pour le premier trimestre clos au ...
Breaking Medicine Technology: