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Combined Molecular-targeted and Hormonal Therapies Offer Promise in Treating Ovarian Cancer

A combination of molecular-targeted therapy and hormonal therapy may be the most promising area of research for those seeking an effective treatment for ovarian cancer, according to a new review in the International Journal of Gynecological Cancer.

Several clinical trials have confirmed the role of hormone therapy in recurrent ovarian cancer treatment, especially in patients with low-grade tumors, says review author Dr. Siqing Fu, an assistant professor of oncology at the University of Texas at Houston. However, more research is needed to determine whether combining molecular-targeted therapy with hormonal therapy would be a more effective option.

Ovarian cancer is the deadliest of gynecological cancers; approximately 70 percent of patients are diagnosed in the later stages, when the 5-year survival rate drops below 25 percent. Traditional chemotherapy has proven to be generally ineffective against recurrent ovarian cancer, which has led researchers to investigate novel treatments.

While a cure is unlikely, the goals of treatment are to control tumor-related symptoms and to improve or maintain quality of life, says Dr. Fu. After surveying the latest research, combined molecular-targeted and hormonal therapy offers the greatest promise in achieving these goals and therefore deserves further investigation.


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