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Combination of Bronchoscopic Techniques is Very Effective for Lung Lesions

on system and requires the operator to maneuver based on prior radiological investigations, such as CT scans. ENB, on the other hand, has a highly specialized real-time navigation system, but lacks a means of directly visualizing the lesion.

The researchers found that the EBUS procedure by itself had a diagnostic yield of 69 percent. ENB alone had a diagnostic yield of 59 percent. But the combination of the two increased the diagnostic yield to 88 percent, independent of lesion sizea highly significant improvement.

In addition, the researchers noted a trend toward improved sensitivity in detecting benign diseases, though it was not statistically significant.

The safety of the combined procedures was assessed by tracking of complications. One of the primary negative outcomes in bronchoscopy is pneumothorax. In this study, the rate of pneumothorax using either ENB or EBUS alone was 5 percent, and in the combined procedures it was 8 percenta statistically insignificant difference.

Another concern was that the extended sedation or anesthesia required in the combined procedure may increase adverse effects due to prolonged sedation or anesthesia, but none was documented.

In his editorial, Dr. Silvestri notes that this study would most likely benefit patients who were too sick to undergo a surgical biopsy but would benefit from chemotherapy if cancer was confirmed through this combined, minimally invasive technique.


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