Navigation Links
Combination Therapy Reduces Tumor Resistance to Radiation

Radiation is used to treat a variety of tumors and the response of tumors to radiation is dependent on endothelial cell death, which in turn limits oxygen delivery to the tumor, causing hypoxia and tumor cell death. Recently, radiation-induced hypoxia was shown to trigger tumor resistance to radiation via the activation of new blood vessel formation (angiogenesis) through molecules known as HIF-1regulated cytokines. In a study appearing online on June 7 in advance of publication in the July print issue of the Journal of Clinical Investigation, Claire Magnon and colleagues from Institut Gustave Roussy, France, show that a combination of radiation treatment and the use of angiogenesis inhibitors such as canstatin is able to overcome HIF-1dependent tumor survival pathways and increases tumor cell death. The authors found that following application of this dual therapy to mice, HIF-1alpha increased the activity of the canstatin-induced tumor apoptotic pathway, which lead to lethal tumor damage. The study demonstrates a crucial role for angiogenesis inhibitors in shifting tumor radioresistance towards tumor apoptosis and suggests that a combination of radiation and angiogenesis inhibitors could potentially be used to overcome HIF-1dependent tumor radioresistance.


'"/>




Page: 1

Related medicine news :

1. Consensus on "Combination Therapy" for Breast Cancer
2. Drug Combinations May Boost Stroke Risk
3. Combination therapy to treat breast cancer
4. Combination regime may work against prostate cancer
5. Smoking and Breast Cancer - A Deadly Combination
6. New Drug Combination Found To Improve Memory in Alzheimer’s Patient
7. A Combination Of Drugs Effective In The Treatment Of Hormone-Refractory Prostate Cancer
8. Combination Therapy Effective In Improving Lung Cancer Survival
9. Combination Therapy Found To Improves Stroke Recovery
10. Combination Therapy Found To Be More Effective In Treating Brain Cancer
11. Combination of Clopidogrel-aspirin is better for preventing stroke than only aspirin
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Combination Therapy Reduces Tumor Resistance Radiation

(Date:12/24/2014)... 25, 2014 The report “Stivarga (Colorectal ... on the current treatment landscape, unmet needs, current pipeline ... is a drug which is used in the treatment ... administered and is also prescribed to patients who suffer ... FDA approved is a multi-kinase inhibitor and it blocks ...
(Date:12/24/2014)... 24, 2014 (HealthDay News) -- Hepatitis C infection does not ... a new study. Treatment advances have made it possible ... develop memory and thinking problems, mood swings and other types ... It,s believed that long-term infections with other viruses -- ... the brain. One of the prime suspects has been the ...
(Date:12/24/2014)... 2014 (HealthDay News) -- A lab technician with the ... been exposed to the Ebola virus in an agency ... to a dozen other lab workers are being checked ... The possible exposure occurred Monday when CDC scientists ... the potentially lethal virus to another CDC lab in ...
(Date:12/24/2014)... 24, 2014 Dr. Svetlana Gomer, MGS ... the nation gathered with US Marines on November 14, ... funds for the Toys for Tots Literacy Program. ... of new books and audio books for the Toys ... children this Christmas. It represents another major strike in ...
(Date:12/24/2014)... 2014 For nearly 20 years, June ... babies, graces, and all of life's rites of passage. ... Nancy Tupper Ling, in Toasts: The Perfect Words ... , Organized by category and containing many original ... anywhere else, this timely tome contains sayings famous and ...
Breaking Medicine News(10 mins):Health News:Stivarga Colorectal Cancer Treatment Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Stivarga Colorectal Cancer Treatment Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Hepatitis C Infection Isn't Related to HIV Brain Woes: Study 2Health News:CDC Monitors Lab Worker for Possible Ebola Exposure 2Health News:Dr. Svetlana Gomer, MGS Tewksbury Dental and Other Dentists Working With the U.S. Marines Strike Again In the Battle Against Illiteracy 2Health News:Dr. Svetlana Gomer, MGS Tewksbury Dental and Other Dentists Working With the U.S. Marines Strike Again In the Battle Against Illiteracy 3
... sleeping five hours or less per day when their babies ... substantial weight retention (11 pounds or more) at their babys ... according to a new study by Kaiser Permanente and Harvard ... The study, published in the November issue of the American ...
... Optimal Nutrition Inc. Chooses ,it, Girl PR to help promote ... ... 19 "it" Girl Public relations, one of,the leading Public ... addition of Optimal Nutrition Inc. (O.N.I.).,O.N.I. bestows a customized door-to-door ...
... to Offer Innovative Coverage Options, Expand Agency ... Representation in Massachusetts -, ... THG ), a leading writer of auto, home and,business ... Insurance approval to offer an enhanced auto product that will,deliver ...
... 19 CorVel Corporation,(Nasdaq: CRVL ) today ... common stock under the stock repurchase program previously ... 2006, the Board had approved a,1,500,000 share expansion ... Company has repurchased 862,323 shares, with a remaining ...
... also made, MINNEAPOLIS, Nov. 19 At ... of Directors of ClearWay Minnesota approved 11,grants for ... to Breathe Act,s,impact on young adults to interventions ... Chicano Latino youth and African,immigrants. ClearWay Minnesota will ...
... Brings Global U.N. Environment Initiative to Northern ... Education,Activities, MORRISTOWN, N.J., Nov. 18, 2007 ... responsibility, today Bayer,employee-volunteers and Girl Scouts from ... their sleeves, grabbed their spades and planted ...
Cached Medicine News:Health News:Kaiser Permanente/Harvard Medical School study links lack of sleep to weight gain for new moms 2Health News:'it' Girl Public Relations Adds 'O.N.I.' New Organic Food Delivery Service to Its Lifestyle Division 2Health News:The Hanover Seeks to Cut Auto Rates by Up to 30 Percent or More; Shave Three Years Off State's Existing Six-Year Surcharge Period 2Health News:The Hanover Seeks to Cut Auto Rates by Up to 30 Percent or More; Shave Three Years Off State's Existing Six-Year Surcharge Period 3Health News:The Hanover Seeks to Cut Auto Rates by Up to 30 Percent or More; Shave Three Years Off State's Existing Six-Year Surcharge Period 4Health News:CorVel Corporation Announces Resumption of Stock Repurchases 2Health News:CorVel Corporation Announces Resumption of Stock Repurchases 3Health News:ClearWay Minnesota(SM) Board Approves $2.8 Million for Research Grants 2Health News:ClearWay Minnesota(SM) Board Approves $2.8 Million for Research Grants 3Health News:Bayer Awards Making Science Make Sense Grant to Girl Scouts 2Health News:Bayer Awards Making Science Make Sense Grant to Girl Scouts 3Health News:Bayer Awards Making Science Make Sense Grant to Girl Scouts 4Health News:Bayer Awards Making Science Make Sense Grant to Girl Scouts 5
(Date:12/24/2014)... , Dec. 23, 2014 ResMed (NYSE: ... patent infringement action against Chinese medical device manufacturer BMC Medical ... ruled today that BMC,s masks listed below infringe ResMed,s patents, ... selling these masks in the United States ... N2 nasal mask , Willow nasal pillows mask ...
(Date:12/24/2014)... 2014  The American Diabetes Association is recommending ... people with diabetes and that all people with ... statins, in keeping with recent changes to guidelines ... College of Cardiology (ACC) and American Heart Association ... recent changes to the Association,s annual revised Standards ...
(Date:12/22/2014)... N.J. , Dec. 22, 2014  CytoSorbents ... marketing its CytoSorb® blood purification technology to help ... patients in 28 countries worldwide, today announced the ... , MD, FACS, as its Senior Vice President ... Dr. Di Russo is ...
Breaking Medicine Technology:ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5
... Health Media, LLC (AHM) has acquired Ephikacy, LLC, the ... the pharmaceutical and life sciences industries. , Advanced Health ... supplying automation and compliance management systems to more than ... than 200 brands. The addition of Ephikacy,s product ...
... Anderson Independent Mail reported that the Partnership ... Anderson and Seneca, South Carolina last month. , The ... America (PhRMA), travels around the country helping people get ... was grateful the bus stopped in Anderson. She and her husband ...
Cached Medicine Technology:Advanced Health Media Announces Acquisition of Ephikacy, LLC 2Advanced Health Media Announces Acquisition of Ephikacy, LLC 3'Help is Here Express' Arrives in Anderson, Seneca 2
The Tissue Approximating Forceps are to aid in the approximating of the tissue edges....
The Auto Suture™ SIGNET™ staplers place one staple each time the instrument handles are squeezed. The staples first penetrate the skin and are then formed, thus holding the tissue togethe...
The Auto Suture DFS stapler is a disposable fascia stapler. The stapler places one staple each time the instrument handles are activated. The staples first penetrate the fascia and are then formed, t...
... is a full-feature skin stapler with a ... has improved visibility over existing fixed-head skin ... for easier staple placement., ,This Skin ... instrument designed to deliver rectangular, stainless steel ...
Medicine Products: