Navigation Links
Combination Therapy More Effective Than Monotherapy for Treating Migraine

Combining two different types of treatment for migraine results in better symptom relief than taking either one of the medications//, according to a study.

"Migraine is a prevalent, often debilitating disease manifested by attacks of bilateral or unilateral headache and associated symptoms, such as nausea, vomiting, and sensitivity to light and sound," according to background information in the article. While advances have been made in treatment, results are still often unsatisfactory for many patients. None of the currently available medications taken alone provide broad coverage of the multiple pathogenic processes in migraine, which is thought to involve multiple neural pathways. A multimechanism-targeted therapy may confer advantages over a single therapy.

Jan Lewis Brandes, M.D., of the Nashville Neuroscience Group, Nashville, Tenn., and colleagues evaluated the effectiveness and safety of treating migraine by combining the migraine medications sumatriptan (in the class of drugs known as triptans) and naproxen sodium (a nonsteroidal anti-inflammatory drug; NSAID) compared with placebo and single therapy with either of the drugs. The research consisted of two identical, randomized, double-blind studies conducted among 1,461 (study 1) and 1,495 (study 2) patients at 118 U.S. clinical centers who were diagnosed as having migraine and received study treatment for a moderate or severe migraine attack. Patients were randomized to receive a single tablet containing both sumatriptan, 85 mg, and naproxen sodium, 500 mg; sumatriptan, 85 mg (monotherapy); naproxen sodium, 500 mg (monotherapy); or placebo, to be used after onset of a migraine with moderate to severe pain.

The researchers found that sumatriptan–naproxen sodium was more effective than placebo for headache relief at two hours after dosing (study 1, 65 percent vs. 28 percent; and study 2, 57 percent vs. 29 percent;), absence of photophobia (sensitivity to light) at two hours (58 percent vs. 26 percent; and 50 percent vs. 32 percent;), and absence of phonophobia (sensitivity to sound) at two hours (61 percent vs. 38 percent; and 56 percent vs. 34 percent). The absence of nausea two hours after dosing was higher with sumatriptan–naproxen sodium than placebo in study 1, but in study 2 rates of absence of nausea did not differ between sumatriptan–naproxen sodium and placebo. For 2- to 24-hour sustained pain-free response, sumatriptan–naproxen sodium was superior to sumatriptan monotherapy, naproxen sodium monotherapy and placebo. The incidence of adverse events was similar between sumatriptan–naproxen sodium and sumatriptan monotherapy.

"The superior efficacy of sumatriptan–naproxen sodium compared with sumatriptan monotherapy might be explained by its targeting of multiple pathogenic mechanisms in migraine," the authors write.

Source-Eurekalert
RM/B
'"/>




Related medicine news :

1. Consensus on "Combination Therapy" for Breast Cancer
2. Drug Combinations May Boost Stroke Risk
3. Combination therapy to treat breast cancer
4. Combination regime may work against prostate cancer
5. Smoking and Breast Cancer - A Deadly Combination
6. New Drug Combination Found To Improve Memory in Alzheimer’s Patient
7. A Combination Of Drugs Effective In The Treatment Of Hormone-Refractory Prostate Cancer
8. Combination Therapy Effective In Improving Lung Cancer Survival
9. Combination Therapy Found To Improves Stroke Recovery
10. Combination Therapy Found To Be More Effective In Treating Brain Cancer
11. Combination of Clopidogrel-aspirin is better for preventing stroke than only aspirin
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/24/2017)... ... September 24, 2017 , ... Millions of families and businesses worldwide depend ... can provide clean, safe, potable water. However, well water can also become contaminated with ... disease and illness. , The EPA does not regulate private drinking water wells. ...
(Date:9/23/2017)... ... September 23, 2017 , ... A September 5 article ... Kushner, director of Chicago’s Center for Lifestyle Medicine at Northwestern Medicine. While explaining ... notes that the center routinely recommends weight loss surgeries for patients who meet ...
(Date:9/22/2017)... , ... September 22, 2017 , ... ... possible, and they often saves lives. However, if one isn’t accessible in certain ... the availability of defibrillation, I came up with this idea," said an inventor ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... Safe Is Smart Scholarship Sweepstakes.,  , Molli C., a graduate student from Sonora, ... Educational Leadership and Administration at St. Thomas University in Miami, Florida, was selected ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... rooms is celebrating the one year anniversary of its Houston-Fallbrook facility. , ... Dr. Otinwa, Facility Medical Director of First Choice Emergency Room Houston-Fallbrook. “It has ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... , Sept. 7, 2017  Eli Lilly and ... actions to streamline operations to more efficiently focus ... its cost structure. Global workforce reductions, including those ... expected to impact approximately 3,500 positions. ... expects annualized savings of approximately $500 million that ...
(Date:9/7/2017)... Sept. 7, 2017 NuvoAir (formerly called ... announced today a partnership with Novartis Pharma AG to distribute ... position as the leading mobile spirometry platform and Novartis, commitment ... ... ...
(Date:9/6/2017)... Sept. 6, 2017  Robert G. Szewc, M.D., is ... Member in recognition of his contributions to the Medical ... a Nephrologist at the practice of Kidney and Hypertension ... care and hypertension solutions. He has worked in this ... career experience, as well as expertise in kidneys, hypertension, ...
Breaking Medicine Technology: