Navigation Links
Combination Therapy More Effective Than Monotherapy for Treating Migraine

Combining two different types of treatment for migraine results in better symptom relief than taking either one of the medications//, according to a study.

"Migraine is a prevalent, often debilitating disease manifested by attacks of bilateral or unilateral headache and associated symptoms, such as nausea, vomiting, and sensitivity to light and sound," according to background information in the article. While advances have been made in treatment, results are still often unsatisfactory for many patients. None of the currently available medications taken alone provide broad coverage of the multiple pathogenic processes in migraine, which is thought to involve multiple neural pathways. A multimechanism-targeted therapy may confer advantages over a single therapy.

Jan Lewis Brandes, M.D., of the Nashville Neuroscience Group, Nashville, Tenn., and colleagues evaluated the effectiveness and safety of treating migraine by combining the migraine medications sumatriptan (in the class of drugs known as triptans) and naproxen sodium (a nonsteroidal anti-inflammatory drug; NSAID) compared with placebo and single therapy with either of the drugs. The research consisted of two identical, randomized, double-blind studies conducted among 1,461 (study 1) and 1,495 (study 2) patients at 118 U.S. clinical centers who were diagnosed as having migraine and received study treatment for a moderate or severe migraine attack. Patients were randomized to receive a single tablet containing both sumatriptan, 85 mg, and naproxen sodium, 500 mg; sumatriptan, 85 mg (monotherapy); naproxen sodium, 500 mg (monotherapy); or placebo, to be used after onset of a migraine with moderate to severe pain.

The researchers found that sumatriptan–naproxen sodium was more effective than placebo for headache relief at two hours after dosing (study 1, 65 percent vs. 28 percent; and study 2, 57 percent vs. 29 percent;), absence of photophobia (sensitivity to light) at two hours (58 percent vs. 26 percent; and 50 percent vs. 32 percent;), and absence of phonophobia (sensitivity to sound) at two hours (61 percent vs. 38 percent; and 56 percent vs. 34 percent). The absence of nausea two hours after dosing was higher with sumatriptan–naproxen sodium than placebo in study 1, but in study 2 rates of absence of nausea did not differ between sumatriptan–naproxen sodium and placebo. For 2- to 24-hour sustained pain-free response, sumatriptan–naproxen sodium was superior to sumatriptan monotherapy, naproxen sodium monotherapy and placebo. The incidence of adverse events was similar between sumatriptan–naproxen sodium and sumatriptan monotherapy.

"The superior efficacy of sumatriptan–naproxen sodium compared with sumatriptan monotherapy might be explained by its targeting of multiple pathogenic mechanisms in migraine," the authors write.

Source-Eurekalert
RM/B
'"/>




Related medicine news :

1. Consensus on "Combination Therapy" for Breast Cancer
2. Drug Combinations May Boost Stroke Risk
3. Combination therapy to treat breast cancer
4. Combination regime may work against prostate cancer
5. Smoking and Breast Cancer - A Deadly Combination
6. New Drug Combination Found To Improve Memory in Alzheimer’s Patient
7. A Combination Of Drugs Effective In The Treatment Of Hormone-Refractory Prostate Cancer
8. Combination Therapy Effective In Improving Lung Cancer Survival
9. Combination Therapy Found To Improves Stroke Recovery
10. Combination Therapy Found To Be More Effective In Treating Brain Cancer
11. Combination of Clopidogrel-aspirin is better for preventing stroke than only aspirin
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... Ca (PRWEB) , ... March 29, 2017 , ... ... process in many scientific laboratories. The assembly protocols involve many repetitive steps and ... suited for automation, which enables the high-throughput needed, and results in a lower ...
(Date:3/29/2017)... ... March 29, 2017 , ... Hamlin Dental Group, multi-location ... now offering laser dental treatments. Dental lasers are safe and effective options, and can ... options and can improve the overall quality of care. , Dr. Hamid Reza of ...
(Date:3/29/2017)... ... March 29, 2017 , ... Physicians’ Education Resource® (PER®), ... medical education conference for clinicians who manage some of the most difficult-to-treat forms ... , The program will be led by co- chairs Dr. John Marshall, chief ...
(Date:3/29/2017)... ... March 29, 2017 , ... AvePoint , the Microsoft Cloud expert, is ... Richmond, Virginia, located at the Riverfront Plaza, 901 East Byrd Street. AvePoint is celebrating ... Ralph S. Northam and Mayor of Richmond Levar M. Stoney. , Founded in 2001, ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... in order to improve teacher quality, the field must first improve teacher preparation ... popular reform to the next” and that decades of input- and outcome-based research ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... 2017 Research and Markets has announced the ... 2023" report to their offering. ... The ablation device global market is expected ... by 2023. Ablation is the minimally invasive therapeutic ... cancerous or diseased tissue removal, to the removal of abnormally conducting ...
(Date:3/29/2017)... , March 29, 2017  Spiral Therapeutics, Inc. ... with Bionure Farma, S.L. for the worldwide exclusive ... BN119 in the field of otolaryngology for aggregate ... The agreement provides Spiral with the ... a differentiated product profile. Under the terms of ...
(Date:3/29/2017)... --  Royal Philips (NYSE: PHG, AEX: PHIA), ... a company that develops artificial intelligence technology for ... solutions that improve the precision and accuracy of ... partnership aims to build deep learning applications in ... to be applied to massive pathology data sets ...
Breaking Medicine Technology: