The conclusion drawn by the doctors after treating 65 million US citizens with hypertension is to initiate a combination therapy// to bring the blood pressure to normal range quickly, according to New York US (UPI).
A number of clinical studies since long has shown the advantage of giving multiple drugs and Paul Ridker, Professor of Medicine; Brigham and Women’s Hospital and Harward Medical School, Boston told United Press International that blood pressure can be brought to normal range better by using multiple drugs than using a single drug first and adding another drug later.
Keeping the blood pressure in the normal range decreases the risk of CVA, MI and nephropathy.
At the annual meeting of the American Society of Hypertension in New York, Ridker informed the importance of Valsartan (Diovan), an angiotensin receptor blocker in people with hypertension. Further a combination of Valsartan with a standard diuretic can bring the blood pressure further below.
Almost 50% of the patients on this combination therapy could achieve their blood pressure in the normal range compared to 32% on single drug, who could not get their levels to the desired range.
Joel Neutel, Medical director of the Orange County Heart Institute and Research Center, Orange, Calif. Reports from another study that combination of Amlodipine (Norvsc) and ACE inhibitor Quinapril (Accupril) / angiotensin receptor blocker losartan (Cozaar) helps in bringing the blood presuure to normal range than any of these drugs used single.
His study highlighted the importance of multiple drug therapy to monotherapy in diabetics with hypertension.
According to Neutel’s study, 27.5% of the difficult to treat hypertensive patients with blood pressure targets lower than those without diabetes could reach a target of 130/80 mm Hg compared to 12.5% on monotherapy.
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