Navigation Links
Colon cancer Linked to low-folate diet

A diet poor in folic acid appears to enhance the risk of colorectal cancer in laboratory mice which suggested that a similar deficiency //could also be linked to colon cancer in humans, according to a study by Canadian researchers.

Scientists at McGill University in a one-year study of 137 mice, saw that animals that were fed a diet low in folic acid had a greater likelihood of developing colorectal cancer than rodents which were given a fully balanced diet containing adequate folate.

Geneticist Rima Rozen, scientific director of the Montreal Children's Hospital and the study's lead investigator said, "We found tumours in the mice that were on the low-folate diet and no tumors in mice that were on the regular diet."

The researchers observed that one in four mice that were given low-folate diets developed intestinal tumors, with some of the animals developing more than one each, said researchers.

The findings of the study was published on Wednesday in the journal Cancer Research.

Rozen asserted that several human studies have revealed that low intake of folic acid, found in leafy green vegetables and citrus fruits, might be associated with an increased risk of colon cancer. However such studies cannot pinpoint with any accuracy what factor or factors definitely lead to a person developing a certain cancer.

The use of mice in the study allowed researchers to carefully control possible contributing factors — including environment and diet, she said, bringing them closer to a direct cause and effect.

Rozen said "What folate does, or the mechanism we propose in this study, is that lack of folate damages your DNA." Folic acid importance to health is a well established fact. It is needed to help cells retain the integrity of DNA during division. In addition it has been shown to help prevent certain types of heart disease, and women who do not consume sufficient folic acid during pregnan cy are at a risk of producing offspring with neural tube defects like spina bifida.

Rozen however stressed that she's not suggesting people start loading up on folic acid but rather make sure that they get the recommended daily allowance of 400 micrograms by eating foods such as broccoli, spinach and orange juice, or by taking a multivitamin.

She said, "I want to make sure people understand the value of recommended daily allowances. I don't want people to go out and take pharmacologic doses of anything . . . In moderation, folate is important."

The researchers also tested mice with a genetic mutation that impairs the body's ability to metabolize folic acid. It was found that rodents with the mutation and also fed a low-folate diet had more than double the incidence of intestinal tumours.

"It's sort of a double whammy in the sense that it's not only the low dietary folate, but it's the combination," Rozen said, noting that 10 per cent of humans are believed to carry a similar genetic mutation.

According to Dr. Andy Smith, a colorectal cancer surgeon at Sunnybrook Health Sciences Centre in Toronto, the study is important because it appears to confirm the long-held suspicion that inadequate folic acid plays a role in tumor formation.

He said, "It really helps tease out the actual mechanisms." While the mechanism found in mice cannot be though to be exactly the same as in humans, Smith said, "I think in this case it really resonates because of the observations made so clearly in humans that low folate is associated with the development of tumors."

However, Smith said he operates on many people with colorectal cancer who have "beautiful diets."

He said, "Even if you have a healthy diet, you still ought to be talking to your physician about whether you should be having a test to screen for colorectal cancer" recommending that Canadians aged 50 or older should have a fecal occul t blood test or a colonoscopy.

Smith said, "Because while your risk may be reduced, it's not eliminated. And people who live very healthy lives are still vulnerable to colorectal cancer."

It has been estimated that by the end of the year an estimated 20,000 Canadians will have been diagnosed with colorectal cancer and about 8,500 is expected to die of the disease in 2006, making it the second most deadly cancer after lung cancer.

Dr. Sharlene Gill, a medical oncologist at the B.C. Cancer Agency said, "This does support the idea that a balanced, healthy diet that does include an appropriate intake of fruits and vegetables may contribute to a lower incidence of cancer.


NLA
'"/>




Related medicine news :

1. Cancers of Colon & Rectum linked to Cigarette Smoking
2. Need for Colon cancer screening
3. Beer guards against Colon Cancer
4. Important substance in curry conciliate Inflamed Colon
5. Colon cancer linked with common virus
6. Colon cancer risk linked to genes causing Hemochromatosis
7. Death Risk Higher in Obese Women with Colon Cancer
8. Inflammation Linked to Colon Cancer
9. Aspirin Found To Reduce The Risk Of Colon Cancer
10. Blood Marker Found To Predict Colon Cancer
11. Estrogen Found To Protect the Colon Against Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... ... authorized OSHA Training Institute Education Center headquartered in Northern California, has issued an ... extreme heat at their worksites. Employers with workers exposed to high temperatures ...
(Date:6/27/2016)... ... 27, 2016 , ... "FCPX editors can now reveal their media with growing ... said Christina Austin - CEO of Pixel Film Studios. , ProSlice Color brings ... users can now reveal the media of their split screens with growing colorful panels. ...
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, ... its affiliation with Tennessee Counseling Association. This new relationship allows TherapySites ... Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA is extremely ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... announced its strategic partnership with Connance, a healthcare industry leader providing predictive ... proven, proprietary technology combine to provide health systems, hospitals and ambulatory surgical ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... cutting edge technology to revolutionize the emergency ambulance transport experience for the millions ... aware of how Uber has disrupted the taxi industry through the use of ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... SYDNEY , June 26, 2016 One of ... , has announced the formation of a new biotechnology company, Noxopharm ... raise $6m in an IPO and to list on the ASX. ... drug candidate, NOX66, ready to enter a Phase 1 clinical study ... been designed to address one of the biggest problems facing cancer ...
(Date:6/26/2016)... June 27, 2016 Jazz Pharmaceuticals plc (Nasdaq: ... under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as ... Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: CPXX ) ... Daylight Time). As previously announced on May ... definitive merger agreement under which Jazz Pharmaceuticals has commenced ...
(Date:6/26/2016)... Ontario , June 27, 2016  VMS Rehab ... Company,s Board will take whatever measures required to build ... Company,s stock which is currently listed on the OTC ... Wexler, Company Chairman and CEO, "We are seeing an ... difficult to understand, not only by the Company, but ...
Breaking Medicine Technology: