Navigation Links
Cocaine's Use During Pregnancy May Cause Lasting Cellular Effects

t to cause these subtle cognitive impairments.

'We thought that it was important to set up an animal model that recapitulates a key feature of human abuse, that being intravenous exposure to low doses of cocaine,' Stanwood said.

A few years ago, Stanwood and Levitt, professor of Pharmacology and director of the Vanderbilt Kennedy Center, established such a model in rabbits. They found that exposure to low levels of intravenous cocaine during a very short window of time during gestation equivalent to the late first trimester and early second trimester in humans caused specific alterations in brain circuits that use the neurotransmitter dopamine.

Additionally, these cocaine-exposed offspring showed attention problems as well as insensitivity to stimulants like amphetamine, suggesting that cocaine exposure had altered the development of the dopamine pathways in the brain.

'In collaboration with Dr. Eitan Friedman of the City University of New York, we had previously shown a decrease in signaling of a particular receptor protein, the dopamine D1 receptor," Stanwood said. "We know that this receptor is involved in regulating the formation of cortical circuitry. It's also involved in the behavioral effects of amphetamines and cocaine.'

'The current study was an attempt to look at the mechanism of this decrease in D1 receptor signaling,' he said.

Stanwood examined the levels of D1 receptor in brain cells taken from 'teenage' rabbits that were exposed to cocaine during that short, sensitive prenatal period.

He found that cocaine exposure did not alter the total amount of D1 receptor produced in the brain. However, there was a dramatic alteration in the location of the protein within the cell.

'It's not where it should be,' he said. D1 receptors are normally found at the cell surface, but neurons from the cocaine-exposed animals showed the receptor was predominantly sequestered inside the
'"/>




Page: 1 2 3

Related medicine news :

1. Oxygen Usage During Exercise Could Indicate Heart Problems
2. Predicting The Risk Of Preeclampsia During Pregnancy
3. Drugs Taken During Pregnancy Found To Affect Unborn Babies
4. Alcohol Consumption During Pregnancy Not Safe
5. The Importance Of “ Good ”Control Of Diabetes During Pregnanc
6. The Effects Of Dental X-Rays During Pregnancy Questioned
7. The Use Of Antioxidants To Diminish Effects of Alcohol During Pregnancy Questioned
8. Oxygen Consumption During Workouts Could Indicate Heart Problems
9. Folic Acid Supplementation During Pregnancy Could Help Prevent Spina Bifida
10. Being Obese Increases Ones Risk Of A wrong Diagnosis During Medical Imaging
11. Avoiding Drugs During Pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cocaine Use During Pregnancy May Cause Lasting Cellular Effects

(Date:7/22/2014)... Two recent studies indicate that previously untreated ... more abused as children than those without these disorders. And ... ADHD children reduces their otherwise higher risk of later ... causation. , Since over 25% of the population suffer from ... and best treatment for these disorders so as to prevent ...
(Date:7/22/2014)... 22, 2014 The physical demands of ... plyometrics, powerlifting, gymnastics, kettleball lifting, calisthenics, and strongman exercises ... Jason Sobzcak, co-owner of CrossFit East Cobb, ... because extreme workouts like these require high quality supplementation. ... I need to take in about 160 grams of ...
(Date:7/21/2014)... 2014 MillionaireCasket.com, a well-known casket manufacturer from ... caskets to its website. In addition to this, the ... off) for all these brand new items. , MillionaireCasket.com ... great caskets for its current and prospective clients. ... and oak caskets and more. According to the company’s sales ...
(Date:7/21/2014)... 2014 What do romance, sex, motherhood, ... common? You can find them all in Thea Marsh's ... character, Miranda, lives on Martha’s Vineyard with her husband ... New Yorker, and becomes entangled in a steamy affair ... readers to think about what choices they would make. ...
(Date:7/21/2014)... Miami, FL (PRWEB) July 21, 2014 ... Brazil vs. Colombia tickets at the Sun Life Stadium ... in South American football between Brazil and Argentina is one ... getting stronger worldwide, more rivalries are forming with each passing ... coming years is between Brazil and another South American nation, ...
Breaking Medicine News(10 mins):Health News:New Studies Reporting a Higher Incidence of Child Abuse in ADHD and Dyslexia Suggest a Need for Early Medical Treatment, Notes Dr. Harold Levinson 2Health News:New Studies Reporting a Higher Incidence of Child Abuse in ADHD and Dyslexia Suggest a Need for Early Medical Treatment, Notes Dr. Harold Levinson 3Health News:New Studies Reporting a Higher Incidence of Child Abuse in ADHD and Dyslexia Suggest a Need for Early Medical Treatment, Notes Dr. Harold Levinson 4Health News:CrossFit East Cobb Fuels Their Intense Workouts with All-Natural EnergyFirst Supplements 2Health News:CrossFit East Cobb Fuels Their Intense Workouts with All-Natural EnergyFirst Supplements 3Health News:Cheap Maple Caskets Recently Added To China Casket Manufacturer MillionaireCasket.com’s Product Line 2Health News:Thea Marsh Releases Debut Novel that Celebrates and Reaches out to Women Everywhere 2Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Reports Huge Demand for Colombia vs. Brazil Tickets at Sun Life Stadium in Miami in Early September 2Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Reports Huge Demand for Colombia vs. Brazil Tickets at Sun Life Stadium in Miami in Early September 3
... Mango, the very popular and fastest-growing retailer of authentic ... "AKA" seal, a certification confirming that Red Mango,s frozen ... high quality, delicious treat by nationally recognized Celebrity Dietitian ... and nutritionist in Los Angeles by Citysearch.com for the ...
... Physicians Practice and an alliance of businesses in Bucks ... physicians and their staff more time to devote to ... designed to help doctors in Bucks County better handle ... practice. Members of the Bucks County Partners include Doylestown ...
... (Nasdaq: CYBX ) today announced that the company ... year ended April 24, 2009 on Wednesday, June 3, 2009 ... conference call to discuss those results at 9:00 AM EDT ... Results Conference Call Instructions , To listen to ...
... company that will become public from the planned spinoff ... announced that Edward J. Borkowski has been named chief ... Mylan, Inc. since 2002 where he helped transform the ... the largest generic pharmaceutical companies in the world, operating ...
... receive $10,000 scholarships to help with escalating cost ... effort to promote diversity and help with the ... Medical Association (AMA) Foundation has presented 12 outstanding ... Minority Scholars Awards.The awards recognize scholastic achievement, financial ...
... Surgical Information Systems (SIS) successfully completed ... Integrating the Healthcare Enterprise (IHE) Connectathon, and ... Systems Society (HIMSS) Interoperability Showcase in Chicago.(Logo: ... )The Connectathon is the healthcare IT ...
Cached Medicine News:Health News:Red Mango Receives 'AKA' Stamp of Approval From Ashley Koff, R.D., Underscoring Its Commitment to Good Health 2Health News:Red Mango Receives 'AKA' Stamp of Approval From Ashley Koff, R.D., Underscoring Its Commitment to Good Health 3Health News:Physicians Practice and Area Businesses Partner to Improve Patient Care in Bucks County, Pennsylvania 2Health News:Physicians Practice and Area Businesses Partner to Improve Patient Care in Bucks County, Pennsylvania 3Health News:Physicians Practice and Area Businesses Partner to Improve Patient Care in Bucks County, Pennsylvania 4Health News:Cyberonics Announces Conference Call to Discuss Fourth Quarter and Fiscal Year 2009 Financial Results 2Health News:CareFusion Names Edward Borkowski as Chief Financial Officer 2Health News:CareFusion Names Edward Borkowski as Chief Financial Officer 3Health News:CareFusion Names Edward Borkowski as Chief Financial Officer 4Health News:AMA Foundation Names Minority Scholars Award Recipients 2Health News:SIS Completes IHE Connectathon, Participates in HIMSS Interoperability Showcase 2
(Date:7/21/2014)... Oregon , July 21, 2014 ... Allied Market Research titled, "Global biosimilars/follow-on-biologics market (types, ... Company Profiles, Demand, Insights, Analysis, Research, Report, Opportunities, ... the global biosimilars market would reach $35 billion ... 2013. Deeper penetration with clearer regulatory pathways in ...
(Date:7/21/2014)... 21, 2014 By order of the U.S. Bankruptcy ... sale of ophthalmic and optical equipment, designer eyeglass frames, and ... specialists American Optical Services LLC. Online bidding opens ... rapid succession, live auction style, on July 28 beginning at ... will be held July 25 th and 26 th ...
(Date:7/21/2014)... DENVER , July 21, 2014   Aventura ... and mobile applications, announced today that MemorialCare ... network, has successfully implemented its awareness computing solution at the ... View, California.  Orange Coast Memorial ... admitting more than 12,000 patients annually. The Aventura ...
Breaking Medicine Technology:Biosimilars/Follow-on-Biologics Market is Expected to Reach $35 Billion, Globally, by 2020 2Biosimilars/Follow-on-Biologics Market is Expected to Reach $35 Billion, Globally, by 2020 3Biosimilars/Follow-on-Biologics Market is Expected to Reach $35 Billion, Globally, by 2020 4Auction Set For Assets Of National Optical Services Company 2MemorialCare Health System Launches Aventura at Orange Coast Memorial Medical Center 2MemorialCare Health System Launches Aventura at Orange Coast Memorial Medical Center 3MemorialCare Health System Launches Aventura at Orange Coast Memorial Medical Center 4
... N.Y., Jan. 18 On January 17, 2008, the ... LLC, Douglas & London,P.C., Levin Simes Kaiser and Gornick ... have filed over a Billion ($1,000,000,000) Dollar,Class Action lawsuit ... Eastern District of New York, Docket #08-258 before The,Honorable ...
... Embryonic Stem Cell Lines for Therapeutic ... ... has,become the first to report, and painstakingly document, the cloning of a,human ... an,adult donor. The study was published online today by the journal "Stem,Cells.", ...
Cached Medicine Technology:Study Reports Successful Cloning of Human Embryo Using Adult DNA 2Study Reports Successful Cloning of Human Embryo Using Adult DNA 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: