Navigation Links
Cocaine Exposure can Alter Neuronal Development in Zebrafish

Researchers from Boston University School of Medicine (BUSM) have shown that prenatal cocaine exposure in zebrafish (which share the majority of the same genes with humans) can alter neuronal development and acutely dysregulate the expression of circadian genes and those affecting melatonin signaling, growth and neurotransmission.

The circadian factors, including the principal circadian hormone melatonin, can attenuate the prenatal effects of cocaine. These findings appear in the July 11th issue of the journal PLoS ONE. Tens of thousands of babies that have been exposed to cocaine in utero are born in the United States each year.

Multiple human studies suggest there are significant changes in brain development and subsequent brain function of children of drug-addicted parents. However, the extent of the damage and whether it is in part due to confounding environmental, genetic or physiological factors remains controversial.

Using a specifically developed zebrafish, the researchers, Drs. Eva Shang and Irina Zhdanova, found that prenatal exposure to cocaine, in concentrations comparable to those experienced by human embryos, altered the neuronal development in zebrafish and acutely changed embryonic expression of genes regulating growth, neurotransmission and circadian system.

Moreover, we found that the effects of the cocaine exposure were dependent on time of exposure, being more robust in the day, and were blocked or attenuated by the principal circadian hormone, melatonin, produced exclusively at night, said lead author Irina Zhdanova, MD, PhD, an associate professor in the department of anatomy and neurobiology at BUSM.

Thus the circadian system might be at the core of the developmental effects of cocaine and their inter-individual variability, she added.

According to Zhdanova, circadian factors, including melatonin, could provide new therapeutic strategies to counteract the developmental effects of prenatal cocaine exposure.


'"/>




Related medicine news :

1. Medications to Prevent Relapse to Cocaine Use
2. Ritalin May Lower Cocaine Abuse
3. Lethal Heart Condition linked To Cocaine Use
4. Cocaine may cause aneurysms for the coronart artery
5. Regular Use Of Cocaine Can Impair Brain Functions
6. Brain of Cocaine Addicts Smaller In Size
7. Sensations Generated By Cocaine And Methamphetamine Abuse Are Not Same.
8. Cocaine Kates Lover Wants to Kick his Drug Habit
9. Cocaine Acts As Suppressant Not Stimulant In Genetically Altered Mice
10. One Nigerian Cocaine Pedellar Nabbed
11. UN Sounds Alarm Over Rising Cocaine Consumption In Europe
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... Conditions were ... at Cove Island Park on Sunday, with sunny skies, a light breeze and temperatures ... nearly $33,000. , The 5k Run and Walk and 1-mile walk were ...
(Date:4/29/2016)... ... 29, 2016 , ... A new study by a Johns ... hernia have better survival rates if surgery is performed early. Approximately one in ... diaphragm fails to form completely, letting abdominal organs into the chest cavity and ...
(Date:4/29/2016)... ... 2016 , ... The Wharton School of the University ... of the 2016 Wharton Business Plan Competition —as well as the Wharton ... the Committee Award for Most ‘Wow Factor,’ making them the first team in ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... announces the Gyrociser, an exercise invention which aids in proper muscle development. , ... Cooper, CEO and Creative Director of World Patent Marketing. "Globalization has threatened the ...
(Date:4/29/2016)... ... April 29, 2016 , ... Melanoma is the deadliest type of skin cancer. Although only ... majority of skin cancer deaths. More than 10,000 people are expected to die of melanoma ... 62, it is the one of the most commonly diagnosed cancers in young women. A ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 2016  ValGenesis, Inc., the market leader ... today announced that a prominent world provider ... chronic kidney failure has selected ValGenesis Validation ... validation process. The global medical device manufacturer ... manage their validation processes electronically. Upon completion ...
(Date:4/27/2016)... PARIS , le 27 Avril 2016 /PRNewswire/ ... chiffre d,affaires a progressé de +5% sur le ... ventes récurrentes de consommables  Croissance de ... Mauna Kea Technologies (Euronext : ... multidisciplinaire d,endomicroscopie confocale laser, annonce aujourd,hui son chiffre ...
(Date:4/27/2016)... , April 27, 2016 Tie-up ... initiative to save newborns   ... women & newborns in collaboration with Breast Milk Foundation (BMF), ... first Pasteurized Human Milk Bank, ,Amaara, in Delhi-NCR today. This ... food source for infants and should be available to babies ...
Breaking Medicine Technology: