Navigation Links
Cocaine Exposure can Alter Neuronal Development in Zebrafish

Researchers from Boston University School of Medicine (BUSM) have shown that prenatal cocaine exposure in zebrafish (which share the majority of the same genes with humans) can alter neuronal development and acutely dysregulate the expression of circadian genes and those affecting melatonin signaling, growth and neurotransmission.

The circadian factors, including the principal circadian hormone melatonin, can attenuate the prenatal effects of cocaine. These findings appear in the July 11th issue of the journal PLoS ONE. Tens of thousands of babies that have been exposed to cocaine in utero are born in the United States each year.

Multiple human studies suggest there are significant changes in brain development and subsequent brain function of children of drug-addicted parents. However, the extent of the damage and whether it is in part due to confounding environmental, genetic or physiological factors remains controversial.

Using a specifically developed zebrafish, the researchers, Drs. Eva Shang and Irina Zhdanova, found that prenatal exposure to cocaine, in concentrations comparable to those experienced by human embryos, altered the neuronal development in zebrafish and acutely changed embryonic expression of genes regulating growth, neurotransmission and circadian system.

Moreover, we found that the effects of the cocaine exposure were dependent on time of exposure, being more robust in the day, and were blocked or attenuated by the principal circadian hormone, melatonin, produced exclusively at night, said lead author Irina Zhdanova, MD, PhD, an associate professor in the department of anatomy and neurobiology at BUSM.

Thus the circadian system might be at the core of the developmental effects of cocaine and their inter-individual variability, she added.

According to Zhdanova, circadian factors, including melatonin, could provide new therapeutic strategies to counteract the developmental effects of prenatal cocaine exposure.


'"/>




Related medicine news :

1. Medications to Prevent Relapse to Cocaine Use
2. Ritalin May Lower Cocaine Abuse
3. Lethal Heart Condition linked To Cocaine Use
4. Cocaine may cause aneurysms for the coronart artery
5. Regular Use Of Cocaine Can Impair Brain Functions
6. Brain of Cocaine Addicts Smaller In Size
7. Sensations Generated By Cocaine And Methamphetamine Abuse Are Not Same.
8. Cocaine Kates Lover Wants to Kick his Drug Habit
9. Cocaine Acts As Suppressant Not Stimulant In Genetically Altered Mice
10. One Nigerian Cocaine Pedellar Nabbed
11. UN Sounds Alarm Over Rising Cocaine Consumption In Europe
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... Santa Monica, CA (PRWEB) , ... March 28, ... ... expert, Dr. Carson Liu of SkyLex Advanced Surgical, Inc. is thrilled to offer ... newest gastric balloon procedure, and this procedure adds to SkyLex Advanced Surgical’s ...
(Date:3/28/2017)... ... 28, 2017 , ... Public relations pros work hard to earn placements and ... , While many results are clear, much of PR is hard to quantify. Goal-setting ... comes to measurement, firms should always take an all-inclusive approach that takes both traditional ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... Association’s Tri-State Camp Conference in Atlantic City March 13-16, was a busy spot ... team of professional staff discussed strategies for preventing outbreaks among camp communities during ...
(Date:3/28/2017)... ... ... With expansion and efficiency in mind, Patten Seed Company completed relocation of ... opened in Marshallville in 2006, and a bagging and shipping facility has been in ... Patten Seed operations to the Middle Georgia location from their previous home in Lakeland, ...
(Date:3/28/2017)... ... March 28, 2017 , ... Silicon Valley Hair Institute, the San Francisco Bay ... post about women’s hair loss. Although hair transplant procedures can be seen as more ... or genetics can be two reasons a woman may see her hair thinning. , ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... 28, 2017  Medeon Biodesign, Inc., a ... pleased to announce that the Company led and ... Orthopedics, Inc., a San Jose, CA ... for orthopedic extremity applications.  The ... primarily due to procedure volume growth, lifestyle influences ...
(Date:3/28/2017)... 28, 2017 Elysium Health joins ... Cambridge academic scientists ... The Milner Therapeutics Institute today announces Elysium Health as ... committed significant investment for collaborative projects with academic researchers in ... This is the first major research investment outside the U.S. ...
(Date:3/27/2017)... 27, 2017 The National University of ... data analytics company, signed a Memorandum of Understanding ... delivery in the region. Under ... Research and Technology (BIGHEART) at NUS and Holmusk ... related to healthcare IT and medical device development. ...
Breaking Medicine Technology: