Navigation Links
Cocaine Exposure can Alter Neuronal Development in Zebrafish

Researchers from Boston University School of Medicine (BUSM) have shown that prenatal cocaine exposure in zebrafish (which share the majority of the same genes with humans) can alter neuronal development and acutely dysregulate the expression of circadian genes and those affecting melatonin signaling, growth and neurotransmission.

The circadian factors, including the principal circadian hormone melatonin, can attenuate the prenatal effects of cocaine. These findings appear in the July 11th issue of the journal PLoS ONE. Tens of thousands of babies that have been exposed to cocaine in utero are born in the United States each year.

Multiple human studies suggest there are significant changes in brain development and subsequent brain function of children of drug-addicted parents. However, the extent of the damage and whether it is in part due to confounding environmental, genetic or physiological factors remains controversial.

Using a specifically developed zebrafish, the researchers, Drs. Eva Shang and Irina Zhdanova, found that prenatal exposure to cocaine, in concentrations comparable to those experienced by human embryos, altered the neuronal development in zebrafish and acutely changed embryonic expression of genes regulating growth, neurotransmission and circadian system.

Moreover, we found that the effects of the cocaine exposure were dependent on time of exposure, being more robust in the day, and were blocked or attenuated by the principal circadian hormone, melatonin, produced exclusively at night, said lead author Irina Zhdanova, MD, PhD, an associate professor in the department of anatomy and neurobiology at BUSM.

Thus the circadian system might be at the core of the developmental effects of cocaine and their inter-individual variability, she added.

According to Zhdanova, circadian factors, including melatonin, could provide new therapeutic strategies to counteract the developmental effects of prenatal cocaine exposure.


'"/>




Related medicine news :

1. Medications to Prevent Relapse to Cocaine Use
2. Ritalin May Lower Cocaine Abuse
3. Lethal Heart Condition linked To Cocaine Use
4. Cocaine may cause aneurysms for the coronart artery
5. Regular Use Of Cocaine Can Impair Brain Functions
6. Brain of Cocaine Addicts Smaller In Size
7. Sensations Generated By Cocaine And Methamphetamine Abuse Are Not Same.
8. Cocaine Kates Lover Wants to Kick his Drug Habit
9. Cocaine Acts As Suppressant Not Stimulant In Genetically Altered Mice
10. One Nigerian Cocaine Pedellar Nabbed
11. UN Sounds Alarm Over Rising Cocaine Consumption In Europe
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/19/2017)... ... ... “Congratulations! It's A Boy! God’s Gift: A Story of Love”: a children’s book that ... Boy! God’s Gift: A Story of Love” is the creation of published authors, Dale ... Christian Faith Publishing, Dale Anthony and Rachael Anthony’s new book is a perfect gift ...
(Date:8/18/2017)... ... ... ... For Immediate Release                Contact: Julian Teixeira, ... Women Seek Sex and Relationship Advice from their Fathers ...
(Date:8/18/2017)... New York, NY (PRWEB) , ... August 18, ... ... the launch of this summer’s edition of “Vision & Hearing,” advocating for active, ... The campaign focuses on resources available for individuals with hearing impairments and shares ...
(Date:8/18/2017)... O'Fallon, MO (PRWEB) , ... August 18, 2017 , ... ... Charles County, is inaugurating a new charity drive to generate community support for efforts ... for research into cures and treatments for all types of cancer. , Each ...
(Date:8/18/2017)... ... August 18, 2017 , ... Moore Insurance, a ... in east Texas, is launching a regional charity effort to provide publicity assistance ... the Pediatric Brain Tumor Foundation (PBTF) has raised nearly $30 million in donations ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... 3, 2017  Agragen, LLC, a ... the biopharmaceutical, nutraceutical, and aquacultural feed sectors, announces ... lead drug candidates, AGR131.  This drug is designed ... the blood of patients suffering from inflammatory conditions ... disease. Biological ...
(Date:8/2/2017)... Ore. , Aug. 2, 2017  Life Flight Network ... Agreement. The agreement improves patient care and operational efficiency for ... Springfield , Cottage Grove , ... level medical transportation. PeaceHealth and Life Flight Network work collaboratively ... available during transport, or when a time sensitive emergency exists. ...
(Date:7/31/2017)... , July 31, 2017 Three Tru-D SmartUVC ... South Korea . Tru-D, short for "Total Room Ultraviolet ... operating rooms after an environmental services (ES) professional cleans the area with ... ... "Although the BAACH ...
Breaking Medicine Technology: