Navigation Links
Cocaine Exposure can Alter Neuronal Development in Zebrafish

Researchers from Boston University School of Medicine (BUSM) have shown that prenatal cocaine exposure in zebrafish (which share the majority of the same genes with humans) can alter neuronal development and acutely dysregulate the expression of circadian genes and those affecting melatonin signaling, growth and neurotransmission.

The circadian factors, including the principal circadian hormone melatonin, can attenuate the prenatal effects of cocaine. These findings appear in the July 11th issue of the journal PLoS ONE. Tens of thousands of babies that have been exposed to cocaine in utero are born in the United States each year.

Multiple human studies suggest there are significant changes in brain development and subsequent brain function of children of drug-addicted parents. However, the extent of the damage and whether it is in part due to confounding environmental, genetic or physiological factors remains controversial.

Using a specifically developed zebrafish, the researchers, Drs. Eva Shang and Irina Zhdanova, found that prenatal exposure to cocaine, in concentrations comparable to those experienced by human embryos, altered the neuronal development in zebrafish and acutely changed embryonic expression of genes regulating growth, neurotransmission and circadian system.

Moreover, we found that the effects of the cocaine exposure were dependent on time of exposure, being more robust in the day, and were blocked or attenuated by the principal circadian hormone, melatonin, produced exclusively at night, said lead author Irina Zhdanova, MD, PhD, an associate professor in the department of anatomy and neurobiology at BUSM.

Thus the circadian system might be at the core of the developmental effects of cocaine and their inter-individual variability, she added.

According to Zhdanova, circadian factors, including melatonin, could provide new therapeutic strategies to counteract the
'"/>




Page: 1 2

Related medicine news :

1. Medications to Prevent Relapse to Cocaine Use
2. Ritalin May Lower Cocaine Abuse
3. Lethal Heart Condition linked To Cocaine Use
4. Cocaine may cause aneurysms for the coronart artery
5. Regular Use Of Cocaine Can Impair Brain Functions
6. Brain of Cocaine Addicts Smaller In Size
7. Sensations Generated By Cocaine And Methamphetamine Abuse Are Not Same.
8. Cocaine Kates Lover Wants to Kick his Drug Habit
9. Cocaine Acts As Suppressant Not Stimulant In Genetically Altered Mice
10. One Nigerian Cocaine Pedellar Nabbed
11. UN Sounds Alarm Over Rising Cocaine Consumption In Europe
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cocaine Exposure can Alter Neuronal Development Zebrafish

(Date:9/23/2014)... -- Both drinking and getting drunk at an early ... high school students, a new study suggests. The ... who drink, could help expand alcohol-prevention efforts aimed at ... them from becoming binge drinkers, the researchers suggested. , ... use and progression to first heavy use as risk ...
(Date:9/23/2014)... Francisco, CA (PRWEB) September 23, 2014 Avid ... for original 1967 The Doors Eagle Auditorium Seattle concert posters. ... their album “Break On Through” that year. The Seattle Eagles ... to Hawley, “The Doors would return to Eagles Auditorium in ... July poster is not known and comes in three colors. ...
(Date:9/23/2014)... Grinnell Mutual seeks submissions from the ... Midwest. Working Together Making It Better will provide ... projects positively impacting their communities. , “So many ... communities a better places,” said Grinnell Mutual ... Baker. “Their leadership—as coaches, as volunteers, as mentors—help ...
(Date:9/23/2014)... 2014 (HealthDay News) -- Few children who ... behavioral therapy, and the rates vary six-fold across ... finds. Medication alone can manage symptoms for ... if they also receive behavioral therapy (psychotherapy), the ... data in more than 1,500 counties across the ...
(Date:9/23/2014)... recent Oregon survey about an exercise DVD that adds ... of elementary school students found it had a high ... offered clear advantages for overly sedentary educational programs. , ... by the Healthy Youth Program of the Linus Pauling ... , Brain Breaks leads children in 5-7 minute segments ...
Breaking Medicine News(10 mins):Health News:Younger Age at First Drink, Higher Odds for Problem Drinking: Study 2Health News:Younger Age at First Drink, Higher Odds for Problem Drinking: Study 3Health News:Grinnell Mutual Invites Submissions for Innovative, Collaborative Local Projects in Its Second Annual Working Together Making It Better Promotion 2Health News:Kids Taking ADHD Drugs Get Little Psychotherapy: Study 2Health News:'Brain Breaks' increase activity, educational performance in elementary schools 2Health News:'Brain Breaks' increase activity, educational performance in elementary schools 3
... Residents Access to Nursing Home, Assisted Living, Home ... Zip Code Statewide RICHMOND, Va., April 30 The cost ... is rising at a rate outpacing inflation, putting significant financial ... annual study by Genworth Financial. At the same time, ...
... Home, Assisted Living, Home Care and Adult Day Health Care ... The cost of long term ... putting significant financial pressure on those in or near retirement, ... the same time, the current economic downturn has led to ...
... Tissue density tied to chances of disease in middle-age and ... Breast cancer risk assessment and prevention should start much earlier ... examined breast cancer risk factors in young women. , ... their mothers found that breast tissue composition in young women ...
... diagnosed in U.S. have continued to be mild, officials ... World Health Organization on Wednesday raised the swine flu ... pandemic is imminent, and urged countries to implement their ... world health officials that the outbreak could trigger large ...
... Study Gives North Dakotans Access to Nursing Home, Assisted Living, ... Every Zip Code StatewideRICHMOND, Va., April 30 The cost ... a rate outpacing inflation, putting significant financial pressure on those ... Genworth Financial. At the same time, the current economic ...
... Study Gives New Mexico Residents Access to Nursing ... Costs in Nearly Every Zip Code Statewide RICHMOND, Va., April ... in New Mexico is rising at a rate outpacing inflation, ... according to an annual study by Genworth Financial. At ...
Cached Medicine News:Health News:Growth in Washington Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 2Health News:Growth in Washington Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 3Health News:Growth in Washington Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 4Health News:Growth in Texas Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 2Health News:Growth in Texas Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 3Health News:Growth in Texas Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 4Health News:Young Women's Breast Tissue Offers Clues to Cancer Risk 2Health News:WHO Raises Swine Flu Alert 2Health News:WHO Raises Swine Flu Alert 3Health News:WHO Raises Swine Flu Alert 4Health News:WHO Raises Swine Flu Alert 5Health News:WHO Raises Swine Flu Alert 6Health News:Growth in North Dakota Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 2Health News:Growth in North Dakota Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 3Health News:Growth in North Dakota Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 4Health News:Growth in New Mexico Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 2Health News:Growth in New Mexico Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 3Health News:Growth in New Mexico Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 4
(Date:9/23/2014)... Nuclear medicine market is estimated to ... Nuclear are drugs that contain radionuclide-emitting ionization radiation, ... and treat diseases. Increasing incidences of ... and ready availability of radiopharmaceuticals are the major ... awareness and use of SPECT and PET also ...
(Date:9/23/2014)...   LabStyle Innovations Corp . (OTCQB: DRIO), ... announced that it has closed a $4.2 million ... stock and warrants.  No placement agent was used ... expects to secure net proceeds of approximately $4.1 ... intends to use the net proceeds from the ...
(Date:9/23/2014)... YORK , September 23, 2014 /PRNewswire/ ... solution Face2Gene améliorée lors d,une série de ... ), pionnier dans le domaine de l,analyse ... sa solution au stand n° 1035 lors de ... San Diego , en ...
Breaking Medicine Technology:Global Nuclear Medicine Market - Growth, Trends & Forecasts (2014-2019) 2LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 2LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 3LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 4LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 5FDNA exposera sa solution Face2Gene intégrée en ligne avec London Medical Databases (LMD) à l'ASHG 2014 2FDNA exposera sa solution Face2Gene intégrée en ligne avec London Medical Databases (LMD) à l'ASHG 2014 3
... Potential of microRNAs as,Novel Cancer Drug Targets, REHOVOT, ... 2007,/PRNewswire-FirstCall/ -- Rosetta Genomics Ltd , a leading ... Cell by scientists from the Weizmann Institute of ... potential for a,specific, single microRNA (miR-34a) to be ...
... endpoint achieved -- , LAINATE, Italy - July ... positive preliminary results from its,phase II/III study with ... a broad spectrum, semi-synthetic,antibiotic that is not absorbed ... Cosmo's MMX(tm) technology, which delivers the active,ingredient into ...
Cached Medicine Technology:Rosetta Genomics and Weizmann Institute Scientists Identify Role of,microRNA in Cancer Suppression 2Rosetta Genomics and Weizmann Institute Scientists Identify Role of,microRNA in Cancer Suppression 3Rosetta Genomics and Weizmann Institute Scientists Identify Role of,microRNA in Cancer Suppression 4Rosetta Genomics and Weizmann Institute Scientists Identify Role of,microRNA in Cancer Suppression 5Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III,Data with Rifamycin MMX in Infectious Diarrhea 2
... Temporary, Transvenous Pacing Lead System Features an ... lubricated guide catheter. The system is designed ... The system is disposable, for temporary single ... of 7 days or less. The lead ...
Automated slide maker and stainer...
... The new ... an electromagnetic braking ... years of reliable ... whisper-quiet operation. The ...
The Schiller treadmill ergometer is designed for stress tests, sports medicine and cardiology. It is equipped and tested with the latest safety system and has been manufactured under the stringent qu...
Medicine Products: