Navigation Links
Cocaine Acts As Suppressant Not Stimulant In Genetically Altered Mice

Researchers at the Ohio State University have found that cutting off the reward pathway of cocaine on mice by genetically altering a vital target in the brain of the mice makes them shun cocaine//.

Howard Gu, the study’s lead author and an associate professor of pharmacology and psychiatry at Ohio State University said that the researchers were not suggesting that humans be treated in the same way, but had identified the key protein, which controls cocaine’s effects in the body.

'Cocaine blocks dopamine transporters, and this action ultimately is what makes a person feel high,' Gu said. 'We found that cocaine would not produce a high if it could not block the transporters.' The study appears in May 29 issue of the Proceedings of the National Academy of Sciences.

Dopamine is a chemical messenger in the brain, which is vital for the functioning of the nervous system. Cocaine blocks the dopamine transmitter as its principal effect, the researchers altered this gene that codes for the dopamine transporter in the mice.

'By doing so we created a dopamine transporter that resists cocaine but also retains its function of taking up dopamine and carrying it back to the neurons,' Gu said.

Now researchers spilt the mice into two groups, the normal ones and the ones with the altered genes and gave them cocaine injections. 'After the cocaine injections, the normal mice ran all over the place, sniffing and checking everything out in the box over and over again, until we took them out of the box,' Gu said. 'But cocaine seemed to calm the modified mice, as they sat in a corner for long periods of time.'

'Deleting the dopamine transporter itself caused tremendous changes in the mouse brain,' Gu said. 'It’s possible that, somehow, the animals’ brains rewired themselves and, as a result, the mice still felt the effects of cocaine.'

'"/>




Page: 1

Related medicine news :

1. Medications to Prevent Relapse to Cocaine Use
2. Ritalin May Lower Cocaine Abuse
3. Lethal Heart Condition linked To Cocaine Use
4. Cocaine may cause aneurysms for the coronart artery
5. Regular Use Of Cocaine Can Impair Brain Functions
6. Brain of Cocaine Addicts Smaller In Size
7. Sensations Generated By Cocaine And Methamphetamine Abuse Are Not Same.
8. Cocaine Kates Lover Wants to Kick his Drug Habit
9. One Nigerian Cocaine Pedellar Nabbed
10. UN Sounds Alarm Over Rising Cocaine Consumption In Europe
11. Definite Connection Between Receptor Levels and Cocaine Abuse Reveals PET Imaging
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2017)... , ... June 25, 2017 , ... CareSet Labs released ... in New Orleans. This is a new, greatly improved version of the Doctor Referral ... (FOIA) requests by Fred Trotter and subsequently called the the “Doctor Referral Dataset” as ...
(Date:6/25/2017)... ... June 25, 2017 , ... June is Men’s Health Month and the ... common cancer among men in the U.S. and the third most common cause of cancer ... that one man in seven will be diagnosed with prostate cancer during his lifetime. ...
(Date:6/24/2017)... (PRWEB) , ... June 24, 2017 , ... ... in Erie, PA at the Sheraton Erie Bayfront and Erie Convention Center on ... based medicine experience, exhibits, a student quiz bowl, award and scholarship presentations, and ...
(Date:6/24/2017)... ... June 24, 2017 , ... The weather is heating up and ... and business owners should be aware that the summer months provide more than warmer ... locks and keys can be negatively affected from direct exposure to the sun. When ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Rhode Island Quality ... Management Alerts and Dashboards, an innovative new service enabling healthcare providers to proactively ... Management Alerts and Dashboards provide near real-time data about patients admitted to and/or ...
Breaking Medicine News(10 mins):
(Date:6/3/2017)... June 3, 2017  Eli Lilly and Company ... results from the Phase 3 MONARCH 2 study ... 6 inhibitor, in combination with fulvestrant, significantly improved ... alone in women with hormone-receptor-positive (HR+), human epidermal ... who have relapsed or progressed after endocrine therapy ...
(Date:5/30/2017)... Corp. (NASDAQ: DRIO), a leading global digital health company with mobile ... presenting at the 7th annual LD Micro Invitational on Tuesday, June ... of DarioHealth will be giving the presentation and meeting with investors. ... 7th, 2017 at the Luxe Sunset Bel Air Hotel and will ... About LD Micro LD Micro was founded ...
(Date:5/29/2017)... TEL AVIV, Israel, May 29, 2017  Cellect Biotechnology ... of innovative technology which enables the functional selection of ... financial results for the first quarter ended March 31 ... pleased with our accomplishments in the first quarter of ... the first quarter, we announced the treatment of the ...
Breaking Medicine Technology: