Navigation Links
Cocaine Acts As Suppressant Not Stimulant In Genetically Altered Mice

Researchers at the Ohio State University have found that cutting off the reward pathway of cocaine on mice by genetically altering a vital target in the brain of the mice makes them shun cocaine//.

Howard Gu, the study’s lead author and an associate professor of pharmacology and psychiatry at Ohio State University said that the researchers were not suggesting that humans be treated in the same way, but had identified the key protein, which controls cocaine’s effects in the body.

'Cocaine blocks dopamine transporters, and this action ultimately is what makes a person feel high,' Gu said. 'We found that cocaine would not produce a high if it could not block the transporters.' The study appears in May 29 issue of the Proceedings of the National Academy of Sciences.

Dopamine is a chemical messenger in the brain, which is vital for the functioning of the nervous system. Cocaine blocks the dopamine transmitter as its principal effect, the researchers altered this gene that codes for the dopamine transporter in the mice.

'By doing so we created a dopamine transporter that resists cocaine but also retains its function of taking up dopamine and carrying it back to the neurons,' Gu said.

Now researchers spilt the mice into two groups, the normal ones and the ones with the altered genes and gave them cocaine injections. 'After the cocaine injections, the normal mice ran all over the place, sniffing and checking everything out in the box over and over again, until we took them out of the box,' Gu said. 'But cocaine seemed to calm the modified mice, as they sat in a corner for long periods of time.'

'Deleting the dopamine transporter itself caused tremendous changes in the mouse brain,' Gu said. 'It’s possible that, somehow, the animals’ brains rewired themselves and, as a result, the mice still felt the effects of cocaine.'

'"/>




Page: 1

Related medicine news :

1. Medications to Prevent Relapse to Cocaine Use
2. Ritalin May Lower Cocaine Abuse
3. Lethal Heart Condition linked To Cocaine Use
4. Cocaine may cause aneurysms for the coronart artery
5. Regular Use Of Cocaine Can Impair Brain Functions
6. Brain of Cocaine Addicts Smaller In Size
7. Sensations Generated By Cocaine And Methamphetamine Abuse Are Not Same.
8. Cocaine Kates Lover Wants to Kick his Drug Habit
9. One Nigerian Cocaine Pedellar Nabbed
10. UN Sounds Alarm Over Rising Cocaine Consumption In Europe
11. Definite Connection Between Receptor Levels and Cocaine Abuse Reveals PET Imaging
Post Your Comments:
(Date:3/2/2015)... 02, 2015 Dinner preparation and ... to the success of DinnerDork , a ... and delicious for thousands of busy customers. The ... by expanding to offer a total of 6 ... seasonally appropriate classic recipes and comfort foods; Paleo ...
(Date:3/2/2015)... March 02, 2015 Regulatory Compliance ... on quality, regulatory and technical consulting, announces Mr. ... Operating Officer. , Before joining RCA, Mr. ... R&D teams in all aspects of developing safety-critical ... at Covidien (Medtronic), Regulatory Compliance Associates Inc., Baxter ...
(Date:3/2/2015)... TX (PRWEB) March 02, 2015 What ... How should physicians request references? When are interviews scheduled, ... analyze employment opportunities?, Both training and practicing physicians who ... to these questions and more at the PracticeLink Physician ... 18. The drop-in Job Fair is from 5:30 to ...
(Date:3/2/2015)... (PRWEB) March 02, 2015 ProvidaStaff ... name for its educational healthcare division to EDU ... delivering healthcare services to school systems and students nationwide. ... provider to school districts throughout the country,” said Angela ... to be a better organization and the introduction of ...
(Date:3/2/2015)... Minneapolis, Minnesota (PRWEB) March 02, 2015 ... a new strategic relationship with First Protective Insurance ... new initiative will allow First Protective affiliated advisors ... and implementation support that Secura Consultants delivers. ... is a national leader in the design and ...
Breaking Medicine News(10 mins):Health News:DinnerDork Announces New Meal Planning Support for the Home Cook 2Health News:DinnerDork Announces New Meal Planning Support for the Home Cook 3Health News:Regulatory Compliance Associates® Inc. Welcomes Seyed Khorashahi as Chief Operating Officer 2Health News:PracticeLink to Host a Career Advancement Workshop and Job Fair in Houston 2Health News:ProvidaStaff Announces New Name Change to EDU Healthcare for Its Educational Healthcare Division 2Health News:ProvidaStaff Announces New Name Change to EDU Healthcare for Its Educational Healthcare Division 3Health News:Secura Consultants and First Protective Insurance Group Announce Strategic Relationship 2
... and Concept2 Partner for Latest in Series of Indoor ... a pioneer in the virtual,training arena, and Concept2, a ... a series of downloadable indoor rowing workouts.,"iROW and Ripped" ... motivated -- just the boost they need to get ...
... Komen During October, Breast ... Cancer Awareness Month, VENTURA, ... http://www.thinkproducts.com ) has,truly raised the bar for Susan G. Komen for ... dressed in,a delectably pink breast cancer awareness wrapper, is in retail ...
... a recent law signed by,President Bush, patient safety ... is still unavailable to average citizens.,Now patients can ... ) to make truly informed medical decisions. ... safety.,Lacking incentives, shareholders are reluctant to share their ...
... Inc. (NYSE:,VTR) ("Ventas" or the "Company") announced today that ... the close of trading on Thursday,November 8, 2007. A ... Friday, November 9, 2007 at 10:00 a.m. Eastern Time ... by CCBN and can be accessed at the,Company,s website ...
... announcement from the Brookings Institution:, Monday, October 22, ... Brookings Institution Falk Auditorium 1775 Massachusetts Avenue, ... activities in developing countries,has grown rapidly in the last ... short of what is needed to achieve the Millennium,Development ...
... KING CITY, Calif., Oct. 15 Pacific Valley ... Hospital in King City so that,residents in South Monterey ... United States Department of Agriculture (USDA) Rural,Development guarantees the ... one of the largest made in United States history ...
Cached Medicine News:Health News:Get Ripped with New iROW Workout 2Health News:Think Pink for the Cure: thinkproducts Raises Over $50,000 for Breast Cancer Awareness 2Health News:Innovative Healthcare Experience Reports from HealthLat Make Patients More Informed 2Health News:Brookings: Donor Perspectives on Innovative Financing for Global Health 2Health News:Pacific Valley Bank Approves $16.7 Million Loan to Mee Memorial Hospital for Healthcare Services in South Monterey County 2Health News:Pacific Valley Bank Approves $16.7 Million Loan to Mee Memorial Hospital for Healthcare Services in South Monterey County 3
(Date:3/2/2015)... 2015 ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") (NYSE MKT: IMUC) today ... ended December 31, 2014 on March 9, 2015. The Company also ... Thursday, March 12, 2015, at 5:00 pm ET. The call will ...   , , , LIVE CALL:  , ... 92238648. , , , , ...
(Date:3/1/2015)... , March 1, 2015  An innovative ... chronic migraine sufferers sustained relief of their headaches, ... Society of Interventional Radiology ,s Annual Scientific ... the State University New York Empire State College ... intranasal sphenopalatine ganglion (SPG) blocks to give patients ...
(Date:2/27/2015)... N.C. , Feb. 27, 2015 Pharmaceutical ... of managing multiple products for the same indication. This ... those that want to prevent one of their brands ... According to recent research by benchmarking firm, ... products as independent brands rather than together as part ...
Breaking Medicine Technology:ImmunoCellular Therapeutics to Report 2014 Financial Results on March 9, 2015; a Business Update Conference Call and Webcast is Scheduled for March 12, 2015 2Image-guided treatment shown to break the migraine cycle 2Image-guided treatment shown to break the migraine cycle 3Image-guided treatment shown to break the migraine cycle 4New Report Details How to Expand a Pharmaceutical Product Portfolio without Cannibalizing an Established Brand 2
... 16, 2011 The proliferation of brand drug "copay ... more expensive brands, will increase costs by $681 million ... and state employee plans, according to new research from ... Association (PCMA).  The use of these promotions by ...
... brand drug "copay coupon" promotions, which lure insured consumers ... by $308 million in Arkansas over the next decade ... new research from Visante and released by the ... these promotions by state and local government workers alone ...
Cached Medicine Technology:Brand Drug 'Copay Coupons' Undermine Generics, Raise Health Costs by $681 Million in Missouri 2Brand Drug 'Copay Coupons' Undermine Generics, Raise Health Costs by $308 Million in Arkansas 2
... factor 1 (IGF-1) is a polypeptide of 70 ... a number of related insulin-like growth factors present ... sequence homology with proinsulin and has a number ... is growth hormone (GH) dependent to a high ...
...
...
...
Medicine Products: