Navigation Links
Cocaine Acts As Suppressant Not Stimulant In Genetically Altered Mice

Researchers at the Ohio State University have found that cutting off the reward pathway of cocaine on mice by genetically altering a vital target in the brain of the mice makes them shun cocaine//.

Howard Gu, the study’s lead author and an associate professor of pharmacology and psychiatry at Ohio State University said that the researchers were not suggesting that humans be treated in the same way, but had identified the key protein, which controls cocaine’s effects in the body.

'Cocaine blocks dopamine transporters, and this action ultimately is what makes a person feel high,' Gu said. 'We found that cocaine would not produce a high if it could not block the transporters.' The study appears in May 29 issue of the Proceedings of the National Academy of Sciences.

Dopamine is a chemical messenger in the brain, which is vital for the functioning of the nervous system. Cocaine blocks the dopamine transmitter as its principal effect, the researchers altered this gene that codes for the dopamine transporter in the mice.

'By doing so we created a dopamine transporter that resists cocaine but also retains its function of taking up dopamine and carrying it back to the neurons,' Gu said.

Now researchers spilt the mice into two groups, the normal ones and the ones with the altered genes and gave them cocaine injections. 'After the cocaine injections, the normal mice ran all over the place, sniffing and checking everything out in the box over and over again, until we took them out of the box,' Gu said. 'But cocaine seemed to calm the modified mice, as they sat in a corner for long periods of time.'

'Deleting the dopamine transporter itself caused tremendous changes in the mouse brain,' Gu said. 'It’s possible that, somehow, the animals’ brains rewired themselves and, as a result, the mice still felt the effects of cocaine.'

'"/>




Page: 1

Related medicine news :

1. Medications to Prevent Relapse to Cocaine Use
2. Ritalin May Lower Cocaine Abuse
3. Lethal Heart Condition linked To Cocaine Use
4. Cocaine may cause aneurysms for the coronart artery
5. Regular Use Of Cocaine Can Impair Brain Functions
6. Brain of Cocaine Addicts Smaller In Size
7. Sensations Generated By Cocaine And Methamphetamine Abuse Are Not Same.
8. Cocaine Kates Lover Wants to Kick his Drug Habit
9. One Nigerian Cocaine Pedellar Nabbed
10. UN Sounds Alarm Over Rising Cocaine Consumption In Europe
11. Definite Connection Between Receptor Levels and Cocaine Abuse Reveals PET Imaging
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... ... professionals, announced today its affiliation with Tennessee Counseling Association. This new ... network of the Tennessee Counseling Association, adding exclusive benefits and promotional offers. , ...
(Date:6/26/2016)... , ... June 26, 2016 , ... On June 10-11, ... of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, ... the city’s history as home to some of the world’s leading providers of cereal ...
(Date:6/25/2016)... Washington, D.C. (PRWEB) , ... June 25, 2016 ... ... will discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June ... share their work on several important health care topics including advance care planning, ...
(Date:6/25/2016)... Long Beach, CA (PRWEB) , ... June 25, 2016 , ... ... from UCLA with Magna Cum Laude and his M.D from the David Geffen School ... San Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at ...
(Date:6/24/2016)... ... 24, 2016 , ... Those who have experienced traumatic events may suffer from ... avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid this ... coping following a traumatic event. , Trauma sufferers tend to feel a range of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Va. , June 24, 2016 The ... set of recommendations that would allow biopharmaceutical ... (HCEI) with entities that make formulary and coverage decisions, ... the "value" of new medicines. The recommendations ... does not appear on the drug label, a prohibition ...
(Date:6/24/2016)... , June 24, 2016 ... Market by Type (Standard Pen Needles, Safety Pen Needles), ... (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) ... MarketsandMarkets, This report studies the market for the forecast ... to reach USD 2.81 Billion by 2021 from USD ...
(Date:6/23/2016)...  MedSource announced today that it has selected ... of choice.  This latest decision demonstrates MedSource,s commitment ... clients by offering a state-of-the-art electronic data capture ... as the EDC platform of choice in exchange ... has long been a preferred EDC platform by ...
Breaking Medicine Technology: