( but is valuable to researchers as a sta...)Co-infection of Two genetic diseases makes them susceptible to malaria,Health

but is valuable to researchers as a stark example of the genetic interactions that can occur in malaria. He said the research also demonstrates why certain critical issues related to malaria cannot be resolved unless there are scientists equipped with modern technology working directly with people in the areas of Africa most affected by malaria. For example, Williams said, his insights would not have been possible if he had not been working directly with Africans who are routinely exposed to malaria and employing a relatively new technology that allows scientists to quickly screen the genetic profile of a large number of people.

"This is another example of the incredible new insights that emerge from supporting malaria research in Africa," said Andreas Heddini, the MIM Secretariat coordinator. "There are many scientists interested in malaria genetics. But as this study shows, findings that come only from the laboratory will be limited unless they are supported by strong evidence from population studies in Africa."

Interest in fighting malaria by studying particular genetic factors related to the disease has increased over the past few years following the sequencing of the genomes of the most deadly form of malaria and its mosquito carrier.

For example, thanks to the genome sequence, researchers now have in their hands powerful "gene chips" that contain the entire malaria genome and can be used to quickly screen parasites for evidence of virulence or drug resistance, or to uncover how they have evolved to avoid human immune responses. And with the sequence publicly available, leading genomics experts who had done little with malaria are now focusing their talent and technology on the disease.

"But resources and personnel are limited," said Carucci. "To maintain momentum, a large-scale effort must be undertaken to distill from the genome data critical information that will give researchers what they need to select those
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