Navigation Links
'Clumping' Protein Linked to Return of Ovarian Cancer

Johns Hopkins scientists have discovered that women treated for ovarian cancer are at increased risk of a rapid and potentially fatal recurrence if their tumor cells have high// levels of a binding protein that triggers abnormal growth and slows down cell death, both hallmarks of malignancy.

“Now there’s the possibility that testing for NAC-1 protein in cancer tissue removed during surgery might identify women most at risk for recurrence and guide doctors and patients to greater vigilance and extended therapy,” said Ie-Ming Shih, M.D., Ph.D., associate professor of pathology at Johns Hopkins Kimmel Cancer Center. The research also suggests that drugs capable of blocking NAC-1 activity may be a useful strategy in preventing and treating recurrences as well.

A report on the research, the first to link NAC-1 to cancer, appears in the December 5 issue of the Proceedings of the National Academy of Sciences.

“Because recurrent cancers are often what really kill patients, and most ovarian cancer is diagnosed when it’s already advanced, our findings offer women a better chance of catching or preventing recurrent disease early and increasing survival,” says Shih.

An estimated at least 60 percent of advanced-stage ovarian cancer patients who appear to be disease-free after initial treatment develop recurrent disease, according to the researchers.

When the investigators compared levels of NAC-1 among primary and recurrent tumor samples taken from 338 ovarian cancer patients from two hospitals, they found that levels of NAC-1 were significantly higher in recurrent tumors compared with primary tumors taken from the same patient. Women whose primary cancers had high levels of NAC-1 were more likely to suffer a recurrence within one year.

Studying the functions of NAC-1, the researchers genetically modified cells so they made both NAC-1 and a component of the protein found at the ends of natural NAC-1 that is
'"/>




Page: 1 2

Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Clumping Protein Linked Return Ovarian Cancer

(Date:10/1/2014)... for holiday gift ideas? Éminence Organic Skin Care, the leader ... holiday season. Starting October 1st 2014, new spa gift sets ... Choose from two luxury skin care gift sets made from ... or to deliver whole body beauty. , The luxurious ... are formulated to suit all skin types and will tick ...
(Date:10/1/2014)... October 01, 2014 QueenBeeTickets.com is giving music ... the singer’s upcoming North American tour, which has him traveling ... come. , Click here to view the selection ... performer’s newest album, is due to come out on October ... shortly thereafter. Bob Seger concert tickets are available for shows ...
(Date:9/30/2014)... no genetic evidence that high levels of vitamin D ... Some previous research had suggested that elevated levels ... diabetes, raising the possibility of a link between vitamin ... this study, British researchers investigated the association between diabetes ... control blood levels of vitamin D. They found no ...
(Date:9/30/2014)... damaging "brain tsunamis" in injured patients without opening ... reality, thanks to pioneering research at the University ... team, led by Jed Hartings, PhD, research associate ... UC College of Medicine, has shown that spreading ... like tsunami wavescan be measured by the placement ...
(Date:9/30/2014)... Symposia will convene the first conference of its 2014-2015 ... Series on "The Modes of Action of Vaccine ... the conclusion of the Grand Challenges Meeting for that ... Keystone Symposia Global Health Series, supported by the Bill ... awards for 36 investigators from developing countries to attend. ...
Breaking Medicine News(10 mins):Health News:Éminence Organic Skin Care Launches Limited Edition Spa Gift Sets for the Holiday Season 2Health News:Éminence Organic Skin Care Launches Limited Edition Spa Gift Sets for the Holiday Season 3Health News:Bob Seger Presale Tickets: QueenBeeTickets.com Delights Fans with Discounted Tickets for All 20 Stops on Seger’s “Ride Out” Tour with The Silver Bullet Band 2Health News:Gene Study Finds No Proof Vitamin D Guards Against Type 2 Diabetes 2Health News:Researchers show EEG's potential to reveal depolarizations following TBI 2Health News:Researchers show EEG's potential to reveal depolarizations following TBI 3Health News:Keystone Symposia launches 2014-2015 meeting series with Global Health Vaccines Conference 2
... neck pain by spine manipulation appears of little use as ... in the UK to relieve many different types of pain,// ... ,When 16 studies were reviewed it was concluded ... is effective for treating any medical problem. ...
... member of the parliament belonging to the Papua New Guinea parliament ... virus//. He will be the first person in the country to ... unnamed MP could be jailed under a 2003 law that made ... Nation newspaper in Papua New Guinea reported. ,The paper ...
... became known that they had cheated the Medicare by more ... were not mandated and hence was never conducted. ... of the illegal scheme from 1997 to 2005. He and ... beneficiaries and introducing them to several doctor’s and medical labs ...
... (FSA), that the daily intake of salt should be limited to ... mention the amount of salt content in their food labels. A ... either side. ,A public awareness watchdog for Foodstuffs set ... salt in a lot of food products. This is done for ...
... common man that how official failings led to a man ... history of violence. Stuart Robertson was killed by James Smith, ... in October 2004. This report mainly gives us an insight ... , There was a failure to respond adequately ...
... the first of its kinds study conducted by the ... Communications Research (CECCR) found// that Women suffering from breast ... given the opportunity to participate in online support groups. ... to ,openly express themselves trying to make sense of ...
Cached Medicine News:Health News:Research demystifies treatment by manipulation of spine by chiropractors in the UK 2Health News:Salt & Its Intake Causes a Strong debate In UK 2Health News:Study Finds Online Support Groups Emotionally Benefit Women Suffering From 2
(Date:9/30/2014)... -- MiMedx Group, Inc. (NASDAQ: MDXG ), ... and patent-protected processes to develop and market advanced products ... Sports Medicine, Ophthalmic and Dental sectors of healthcare, announced ... Officer, will present at the Stem Cell Meeting on ... 7, 2014, at 5:00PM Pacific Daylight Time. ...
(Date:9/30/2014)... 2014 Arbor Pharmaceuticals, LLC. - Product ... Markets Direct,s, ,Arbor Pharmaceuticals, LLC. - Product Pipeline ... Arbor Pharmaceuticals, LLC.,s pharmaceutical research and development focus. ... current therapeutic developmental pipeline of Arbor Pharmaceuticals, LLC.,s, ... assessment by drug target, mechanism of action (MoA), ...
(Date:9/30/2014)... Sept. 30, 2014  According to their CEO, ... cancer clinical trials is going through a complete ... the work of the current clinical trial management ... ,next generation, clinical trials, which will ultimately drive ... The company has been recognized by the ...
Breaking Medicine Technology:MiMedx to Present at the Stem Cell Meeting on the Mesa 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 3Small Denver Company Pharmatech driving a large revolution in how cancer clinical trials are managed 2
... Today GenVec, Inc. (Nasdaq: GNVC ) announced financial ... 2010.  For the year ended December 31, 2010, the Company ... share, compared with a net loss of $18.4 million, or ... GenVec ended the year with $35.2 million in cash, cash ...
... RIVER EDGE, N.J., March 10, 2011 Nephros, Inc. ... device company developing and marketing filtration products for therapeutic ... completion of its rights offering and private placement that ... to Nephros.  The aggregate net proceeds received by Nephros ...
Cached Medicine Technology:GenVec Reports Fourth Quarter and 2010 Year-End Financial Results 2GenVec Reports Fourth Quarter and 2010 Year-End Financial Results 3GenVec Reports Fourth Quarter and 2010 Year-End Financial Results 4GenVec Reports Fourth Quarter and 2010 Year-End Financial Results 5GenVec Reports Fourth Quarter and 2010 Year-End Financial Results 6GenVec Reports Fourth Quarter and 2010 Year-End Financial Results 7GenVec Reports Fourth Quarter and 2010 Year-End Financial Results 8Nephros Announces Completion of $3.2 Million Financing Through Rights Offering and Private Placement Transactions 2Nephros Announces Completion of $3.2 Million Financing Through Rights Offering and Private Placement Transactions 3Nephros Announces Completion of $3.2 Million Financing Through Rights Offering and Private Placement Transactions 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: