( Researchers have recently reported clue...)Clues to the Mystery of Lou Gehrig's Disease,Health

Researchers have recently reported clues to unraveling the mystery of the disease best known for striking down New York Yankees first baseman Lou Gehrig nearly 70 years ago//.

According to Virginia Lee, Ph.D., of the University of Pennsylvania a team of researchers has identified the misfolded protein that causes both Lou Gehrig's disease or amyotrophic lateral sclerosis (ALS), as well as a less well-known disease, frontotemporal lobar degeneration.

The findings of the study, published in the Oct. 6 issue of Science identify it as TAR DNA-binding protein 43 (TDP-43), that has several functions and is found in the nucleus of many cell types.

Misfolded proteins are a common occurrence in neurodegenerative diseases. They are tagged for recycling by the protein ubiquitin, but instead of being broken down they are dumped in the neurons.

However Dr Lee said that the specific ubiquitinated protein involved in ALS and frontotemporal lobar degeneration had not been earlier identified. She and her colleagues noted that the finding "resolves a long-standing enigma."

Clinical features such as dementia and motor complications are common to both ALS and frontotemporal lobar degeneration patients which made researches consider the likelihood of the two diseases being related in some way.

Tests using tissue samples showed that the motor neurons of ALS patients and the frontal and temporal neurons of frontotemporal lobar degeneration patients contain large amounts of ubiquitinated TDP-43 in their cytoplasm.

The researchers therefore concluded that this finding implied that ALS, frontotemporal lobar degeneration, and possibly other neurodegenerative diseases are part of "a spectrum of disorders that share similar pathological mechanisms, culminating in the progressive degeneration of different selectively vulnerable neurons."

Dr Lee said, "It's very exciting that we finally made the connection between dem
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