Navigation Links
Clues to the Cause of Difficulty With Swallowing

Eosinophilic Esophagitis (EE), a disease, first described in children only 20 years ago, but has shown a rising incidence in both children and adults. //It is said to be an inflammatory condition of the esophagus, symptoms of which includes vomiting, heartburn and difficulty in swallowing.

In findings published on line January 10, 2007 in the Journal of Allergy & Clinical Immunology, researchers at the University of California, San Diego (UCSD) School of Medicine and Rady Children's Hospital and Health Center, San Diego show that the disease causes many of the same kinds of tissue changes seen in pediatric asthma. Their research may lead to new drug targets for EE, which appears to be allergy-driven in some patients.

The esophagus is the soft tube-like portion of the digestive tract that leads from the back of the mouth to the stomach. In patients with EE, the disease leads to scarring and narrowing of the esophagus, so that food can't readily pass through it.

"We set out to find whether the kind of structural changes seen in other long-standing inflammatory diseases like childhood asthma also occur in EE," said Seema Aceves, M.D., Ph.D., of UCSD's Allergy Immunology section of the Department of Pediatrics. Aceves is also a physician at Rady Children's Hospital in San Diego and directs a treatment center for children with eosinophilic gastrointestinal disorders.

The research team studied biopsies of the esophagus from children with an initial diagnosis of EE who had not yet been treated, comparing them to biopsies of children with acid reflux disease as well as those of children with normal esophageal biopsies.

"We found fibrosis, or scarring, as well as remodeling of the esophagus in pediatric EE patients which is similar to airway remodeling found in patients with asthma," said Aceves.

Remodeling occurs in chronic inflammatory diseases such as asthma and results in alterations in structural cells and tissues not found in normal tissues. The UCSD study showed that children with EE were found to have previously unrecognized changes to their esophagus, including an increased number of blood vessels in the sub-epithelium, the region below the surface of the interior lining of the esophagus.

There were also a larger number of adhesion molecules present in these blood vessels, which cause the vessel wall to become sticky. As a result, allergy cells adhere to the sticky vessels and are then able to cross the blood barrier, resulting in inflammation in the esophagus.

These studies – performed by Aceves through an ongoing collaboration with the laboratory of David Broide, M.B. Ch.B., professor of medicine at UCSD School of Medicine and an expert in airway remodeling in asthma – identified three molecules that contribute to these changes in the esophagus, and could provide new therapeutic targets for EE.

Their data suggests that increased expression of the molecules TGF-beta 1, phospohrylated-SMAD2/3, and VCAM-1 may be involved in remodeling that leads to scarring and narrowing of the esophagus. These molecules may serve as markers to provide physicians with a basis for predicting disease severity.

Source-Eurekalert
SR
'"/>




Related medicine news :

1. Innovative yeast genome may handle Cancer Clues
2. Researchers Discover New Clues To Identify Tooth Decay
3. Leeches Provide Clues Regarding The Prevention Of Heart Disease
4. Excavations Reveal Clues Of Early Warfare
5. Sleeping Computers Yield Clues About Genetic Disorders
6. Clues To Identify Psychological Seizures
7. A Human Brain Gene Could Hold Clues On The Evolution Of Brain Capacity
8. Clues to the Mystery of Lou Gehrigs Disease
9. Clues Found On How Deadly Bacterium Gains Foothold
10. Clues to Allay Aging
11. Regrowth of Zebrafishs Tail Fin may Offer Clues for Treating Human Injuries
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... ... December 07, 2016 , ... The Honolulu ... fully redesigned website, which launched October 17, 2016, features comprehensive information regarding a ... easy-to-navigate layout. Visitors and patients can discover the latest clinical dermatology treatments for ...
(Date:12/7/2016)... ... December 07, 2016 , ... The medical profession is well aware that heart ... major study analyzing heart attacks among 138,602 people recorded a 35% higher number of ... would all agree of course–no time of year is a good time for a ...
(Date:12/7/2016)... ... ... Road To Restoration”: an informative and enlightening book for those who believe that ... “The Road To Restoration” is the creation of published author, Thomas Fitzhugh Sheets, seventy-one-year-old ... you could reach out for, and grab, on the old carousels. If you ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... fifth annual Business Architecture Innovation Summit in Reston, VA on March 21-22, 2017. ... will share a range of experiences from a cross-section of industries such as ...
(Date:12/6/2016)... Korea (PRWEB) , ... December 06, 2016 , ... ... Inc. have agreed to collaborate in developing a vaccine against the Middle East ... a vaccine can be available in South Korea for emergency deployment in the ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... 2016  Organovo Holdings, Inc. (NASDAQ: ... on delivering scientific and medical breakthroughs using its ... Chief Executive Officer Keith Murphy is ... 14, 2016 at 1:00 p.m. Eastern Time (ET). ... familiar with the Company, an informational video and ...
(Date:12/7/2016)... , Dec. 7, 2016  Lannett Company, Inc. (NYSE: ... the BMO Capital Markets 2016 Prescription for Success Healthcare Conference on ... hotel in New York City . ... participating at the Guggenheim Securities 4 th Annual Boston Healthcare ... hotel. ...
(Date:12/6/2016)... , Dec. 6, 2016  "Blood Tests replace ... announced ....." The Diagnostic, Monitoring and Screening ... cancer diagnostics is occurring using in vitro blood ... company with impressive backing, has announced a single ... is moving faster than the market. New technology ...
Breaking Medicine Technology: