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Clotting Protein plays a role in nerve repair

ccording to him, fibrin has two effects on the repair process. As it does in other types of injury, the protein helps stop bleeding, he said. But fibrin also helps choreograph the repair process, he explained.

The presence of fibrin tells neurons and supporting cells that there has been an injury. But the repair process does not start until the injury is resolved and fibrin stops leaking in from the blood. Strickland pointed out that just as it would not make sense to refinish a damaged floor without first repairing the leaky roof, it would not make sense to begin repairing myelin until the injury was under control.

It may be possible to improve the regeneration of myelin by targeting fibrin in people with multiple sclerosis, Strickland said. He cautioned, however, that there is not yet an effective way to target fibrin that leaks into a nervous system injury without targeting fibrin throughout the body. Since fibrin is essential for blood clotting, blocking the protein throughout the body would not be a workable treatment.


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