Navigation Links
Clotting Protein plays a role in nerve repair

According to a new study, fibrin, a protein that helps form blood clots, may also be involved in regulating the repair of nerve damage. The discovery could lead to new strategies for repairing diseases of the nervous system, such as multiple sclerosis, although the research is still on the basic science level.//

In multiple sclerosis, the slow destruction of myelin--the thin, protective coating that insulates nerve fibers in the brain and spine can lead to numbness, muscle weakness and stiffness, impaired vision and coordination problems. In nerves outside the brain or spinal cord, loss of myelin can also occur after an injury.

Previous research has shown that fibrin gathers in the lesions of people with multiple sclerosis, but the protein's role in nerve repair has not been studied widely. Now Dr. Sidney Strickland and colleagues at Rockefeller University in New York report that fibrin seems to play a critical role in repairing damaged myelin. The researchers made the discovery by studying mice that lacked the protein. After an injury to the sciatic nerve (located in the leg), myelin regenerated much more rapidly in fibrin-free mice than in normal mice.

Strickland's team describes fibrin's role in the repair process--at least outside the brain and spinal cord. After a nerve injury, it seems that a protein called fibrinogen can leak from the blood into the damaged nerve. Once in the nerve, fibrinogen is converted into fibrin. While this is going on, myelin-repairing cells called Schwann cells begin proliferating. But the presence of fibrin keeps Schwann cells from beginning their repair job.

As fibrin is gradually dissolved, however, Schwann cells are able to begin repairing the damaged myelin and regenerating the myelin sheath as the nerve grows. Schwann cells help repair nerves outside of the brain and spinal cord, while a second type of cell has at least "limited capacity" to repair myelin in the brain.

A ccording to him, fibrin has two effects on the repair process. As it does in other types of injury, the protein helps stop bleeding, he said. But fibrin also helps choreograph the repair process, he explained.

The presence of fibrin tells neurons and supporting cells that there has been an injury. But the repair process does not start until the injury is resolved and fibrin stops leaking in from the blood. Strickland pointed out that just as it would not make sense to refinish a damaged floor without first repairing the leaky roof, it would not make sense to begin repairing myelin until the injury was under control.

It may be possible to improve the regeneration of myelin by targeting fibrin in people with multiple sclerosis, Strickland said. He cautioned, however, that there is not yet an effective way to target fibrin that leaks into a nervous system injury without targeting fibrin throughout the body. Since fibrin is essential for blood clotting, blocking the protein throughout the body would not be a workable treatment.


'"/>




Related medicine news :

1. FDA Approves New Anti-Clotting Drug
2. Blood Clotting Protein Discovered
3. Blood Clotting Disorders Linked To Three Proteins
4. Scientist Discovers Crucial Part of Blood-Clotting Process
5. Predicting the Dynamics of Clotting in Human Blood
6. New Anti-Clotting Drug Less Risky For Heart Attack Patients
7. Lean Protein Could Be Key to Obesity Drugs
8. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
9. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
10. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
11. Protein in urine foresees heart disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/15/2019)... ... October 15, 2019 , ... Nashville Fertility Center (NFC) is proud ... doctor to join the practice. In addition to treating general infertility, Dr. Van Heertum ... team at NFC looks forward to Dr. Van Heertum joining the practice and believes ...
(Date:10/11/2019)... (PRWEB) , ... October 11, 2019 , ... A Topping ... (STA) new headquarters facility by general contractors Adolfson & Peterson Construction. The event celebrated ... 2020 at 8190 Midtown Road in Dallas. The first of its kind in Texas, ...
(Date:10/10/2019)... ... , ... Caring.com, a leading senior care referral service with Family Advisors nationwide, ... to Live. All 50 states and 302 cities in the U.S. were ranked based ... , According to the U.S. Census Bureau , almost 20 million Americans will ...
(Date:10/8/2019)... (PRWEB) , ... October 08, 2019 , ... What unique ... and future state of aging and wellness in the nation? That question will be ... Active Aging Conference, Leadership Summit and Expo. The event will take place October 10-12, ...
(Date:10/8/2019)... (PRWEB) , ... October 08, 2019 , ... Dr. Amir ... disease in San Jose, CA experience relief from this common and treatable condition. Dr. ... order to save adults from living with uncomfortable symptoms, including tender and bleeding gums, ...
Breaking Medicine News(10 mins):
(Date:10/22/2019)... (PRWEB) , ... October 23, 2019 , ... ... were recognized in Baltimore magazine’s November 2019 “Top Docs” issue, representing 22 separate ... , Dr. John Campbell, Orthopedic Surgery: Foot & Ankle, Dr. Rebecca Cerrato, Orthopedic ...
(Date:10/19/2019)... (PRWEB) , ... October 18, 2019 , ... Beginnings Treatment ... to act as the official sponsor of the Alcohol and Other Drug Awareness ... to empower students to make informed decisions around alcohol and other drugs through individual ...
(Date:10/19/2019)... ... October 18, 2019 , ... A new study ... suggests adalimumab use in pregnancy was not associated with an increased risk for ... delivery. The findings were published today in the Public Library of ...
Breaking Medicine Technology: