Navigation Links
Closing in on Lethal Heart Rhythm in Young Athletes

Johns Hopkins experts on the genetics of a potentially lethal heart rhythm defect that runs in families and targets young athletes report they have greatly narrowed //the hunt for the specific genetic mutations that contribute to the problem.

Their new findings, described in the July issue of the American Journal of Human Genetics, should increase the accuracy of tests to identify those at risk for arrhythmogenic right ventricular dysplasia (ARVD), which is among the top causes of sudden cardiac death in the young and fit.

In February, the same team linked one-third of ARVD cases in their large database of patients to a dozen abnormal changes in a gene called plakophilin-2 (PKP2), which makes proteins involved in heart cell stickiness.

In the new study, confirming experiments elsewhere, the Hopkins team found four mutations in another sticky protein gene, Desmoglein-2 (DSG2), in five of 33 patients tested.

“This gene is highly expressed in the heart, where muscle tissue expands and contracts with the heartbeat,” says senior study author and cardiac geneticist Daniel P. Judge, M.D. “Our results confirm that altered genes in the desmosomal cellular complex are responsible for ARVD. And now that we know the genetic roots of this disease, we can also create better blood tests for their proteins to predict who is at risk for developing this condition.”

ARVD is characterized by weakness in the desmosome, or cell-to-cell binding structure. The inherited condition leads to the buildup of excess fatty and scar tissue in the heart’s right ventricle, causing irregular beats and - unless diagnosed and treated with drugs or implanted defibrillators - triggering a fatal heart rhythm disturbance.

Judge, an assistant professor at The Johns Hopkins University School of Medicine and its Heart Institute, says DSG2 mutations appear to account for at least 10 percent and possibly more of the estimated 25,000 deaths
'"/>




Page: 1 2 3

Related medicine news :

1. Closing In On the Breast Cancer Gene
2. Brain Networks Strengthened by Closing Ion Channels
3. Lethal Heart Condition linked To Cocaine Use
4. Toll-like Receptor (Tlr3) Attachment Leads To Lethal Encephalitis
5. How Lethal Is The H5N1?
6. Whirlpool Bath Tubs Contain Potentially Lethal Bacterial Strains
7. Mineral Water Stored In Plastic Containers For Long Could Be Lethal
8. Echocardiography-Guided Genetic Test Could Improve Screening For Lethal Heart Condition
9. Elements In Grape fruit Juice Combine Lethally with Certain Drugs, leading to potentially dangerous side effects, study.
10. Warning! Working For Long Hours On Your Computer Can Be Lethal
11. "Serious Failings" Led To Spread Of Lethal Hospital Bug
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Closing Lethal Heart Rhythm Young Athletes

(Date:4/23/2014)... As evidence mounts showing the potential health benefits of ... people are taking supplements. And the chemical industry is ... supplements, health effects could deter growth, so the industry ... claims, according to the cover story in Chemical ... of the American Chemical Society. , Melody M. Bomgardner, ...
(Date:4/23/2014)... R.I. Parents and physicians concerned about an increase ... marijuana can breathe a sigh of relief. According to ... 20 years worth of data from states with and ... lead to increased use among adolescents. The study is ... Journal of Adolescent Health . , "Any time ...
(Date:4/23/2014)... has been a rapidly evolving pursuit with many ... in the research road, scientists have found a ... with the disease. The report, which appears in ... have important implications for developing novel treatments. , ... that for years, research has suggested a link ...
(Date:4/22/2014)... for low-income patients may ease the financial burden ... patient health, researchers have concluded. , A study ... avoid costs associated with insurance administration can help ... and emergency room visits, according to Mark Agee, ... The researchers estimated that the major hospital in ...
(Date:4/22/2014)... The International Communication Association will hold its ... The theme of the 2014 conference will explore ... and digital society. , Featuring over 2,300 academic ... Communication scholars representing over 40 countries, the ICA ... in the world. This year,s conference features sessions ...
Breaking Medicine News(10 mins):Health News:RI Hospital physician: Legalizing medical marijuana doesn't increase use among adolescents 2Health News:Clinics not bogged down by red tape can ease health cost burdens 2Health News:International Communication Association to hold Annual Conference in Seattle, Washington 2
... be GI Awards, Honored for Commitment to Patient ... ... Procter and Gamble,Pharmaceuticals (P&G) is encouraging GI and Endoscopy professionals to,recognize outstanding ... support of the Society of Gastroenterology,Nurses and Associates, Inc. (SGNA) GI Nurses ...
... The apples and apple juice you consume may have ... in the body in the colon. New ... apple juice components actually enhance biological mechanisms that produce ... Using human fecal matter as the test substance, German ...
... MD: Artemisinins in Malaria Therapy, written by WRAIR researchers Dr. ... J. Weina (Division of Experimental Therapeutics at the WRAIR, Silver ... and recent developments in the treatment of one of the ... mankind malaria. , WRAIR, initially known as the Army ...
... Vitamin Stix Drink Mix, BROOKLYN, N.Y., March 26 ... your vitamins, 4C Totally Light2Go(TM) Vitamin Stix!,Packed with vitamins ... quickly becoming a staple for the gal on the ... three flavors of the 4C,Totally Light2Go(TM) Vitamin Stix have ...
... Increase of 126% ... -, - Removal of the Going Concern Qualification by its Independent ... Public Accountants - ... March 26 XELR8 Holdings, Inc. (Amex:,BZI), a provider of functional foods, beverages and nutritional,supplements, today ...
... SHANGHAI, China, March 26 /Xinhua-PRNewswire-FirstCall/ -- ... a leading developer,manufacturer and distributor of ... that its wholly owned subsidiary Shanghai ... an agreement with Shanghai,Disinfection Association (SDA), ...
Cached Medicine News:Health News:Nationwide Awards Recognize Nurses, Associates and Nursing Teams That Specialize in Gastroenterology and Endoscopy 2Health News:Nationwide Awards Recognize Nurses, Associates and Nursing Teams That Specialize in Gastroenterology and Endoscopy 3Health News:WRAIR investigators pioneering work on an exciting new class of antimalarial compounds 2Health News:Flavor and Vitamins on the Go 2Health News:XELR8 Holdings Announces Fiscal 2007 Financial Results 2Health News:XELR8 Holdings Announces Fiscal 2007 Financial Results 3Health News:XELR8 Holdings Announces Fiscal 2007 Financial Results 4Health News:XELR8 Holdings Announces Fiscal 2007 Financial Results 5Health News:XELR8 Holdings Announces Fiscal 2007 Financial Results 6Health News:XELR8 Holdings Announces Fiscal 2007 Financial Results 7Health News:XELR8 Holdings Announces Fiscal 2007 Financial Results 8Health News:Shanghai Disinfection Association and Linkwell Corporation Co-Establish the 'Shanghai Disinfection Association Laboratory Center' 2Health News:Shanghai Disinfection Association and Linkwell Corporation Co-Establish the 'Shanghai Disinfection Association Laboratory Center' 3
(Date:1/15/2014)... WORTH, Texas , Jan. 15, 2014  Humberto C. ... Dermatology Achievement Award" from the Journal of Drugs ... Aesthetic & Clinical Conference (ODAC). The event is January 17-20, ... Florida . The ODAC ...
(Date:1/15/2014)... WOONSOCKET, R.I. , Jan. 15, 2014 MultiCell ... has filed a U.S. provisional patent application concerning composition ... formulations to achieve targeted tumor cell death.  ... very small noncoding double stranded RNA molecules (VSRNAs) which ...
(Date:1/15/2014)... NEW YORK , Jan. 15, 2014 ... research report is available in its catalogue: ... - India Drug Forecast and Market Analysis ... PharmaPoint: Atopic Dermatitis - India ...
Breaking Medicine Technology:Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5
... Worldwide, Inc. (NYSE: OWW ) will host a conference call to discuss the ... Wednesday, May 5, 2010 at 10:00 a.m. EDT ( 9:00 a.m. CDT ... (Logo:   http://www.newscom.com/cgi-bin/prnh/20070813/AQM125LOGO ) , ... A live webcast of the call can be accessed through the Orbitz Worldwide Investor Relations ...
... Anthera Pharmaceuticals, Inc. (Nasdaq: ANTH ), a biopharmaceutical company ... Paul F. Truex , Anthera,s President and Chief Executive Officer will present ... MA on Monday, May 3, 2010 at approximately ... , , ...
Cached Medicine Technology:Orbitz Worldwide, Inc. to Host First Quarter 2010 Earnings Call on May 5 2Orbitz Worldwide, Inc. to Host First Quarter 2010 Earnings Call on May 5 3Anthera Pharmaceuticals to Present at Deutsche Bank Securities' 35th Annual Health Care Conference 2
MedLook 3.0 is a medical billing software....
Managed care is a billing and tracking system....
... billing program dealing with the clerical aspects ... standard Health Insurance Claim Form, or CMS-1500. ... the internet. This means that you can ... home or work without using a web ...
... is a medical practice management ... tools and interfaces. This medical ... scheduling, patient demographics, insurance company ... paper and electronic claims filing ...
Medicine Products: