Navigation Links
Closing in on Lethal Heart Rhythm in Young Athletes

Johns Hopkins experts on the genetics of a potentially lethal heart rhythm defect that runs in families and targets young athletes report they have greatly narrowed //the hunt for the specific genetic mutations that contribute to the problem.

Their new findings, described in the July issue of the American Journal of Human Genetics, should increase the accuracy of tests to identify those at risk for arrhythmogenic right ventricular dysplasia (ARVD), which is among the top causes of sudden cardiac death in the young and fit.

In February, the same team linked one-third of ARVD cases in their large database of patients to a dozen abnormal changes in a gene called plakophilin-2 (PKP2), which makes proteins involved in heart cell stickiness.

In the new study, confirming experiments elsewhere, the Hopkins team found four mutations in another sticky protein gene, Desmoglein-2 (DSG2), in five of 33 patients tested.

“This gene is highly expressed in the heart, where muscle tissue expands and contracts with the heartbeat,” says senior study author and cardiac geneticist Daniel P. Judge, M.D. “Our results confirm that altered genes in the desmosomal cellular complex are responsible for ARVD. And now that we know the genetic roots of this disease, we can also create better blood tests for their proteins to predict who is at risk for developing this condition.”

ARVD is characterized by weakness in the desmosome, or cell-to-cell binding structure. The inherited condition leads to the buildup of excess fatty and scar tissue in the heart’s right ventricle, causing irregular beats and - unless diagnosed and treated with drugs or implanted defibrillators - triggering a fatal heart rhythm disturbance.

Judge, an assistant professor at The Johns Hopkins University School of Medicine and its Heart Institute, says DSG2 mutations appear to account for at least 10 percent and possibly more of the estimated 25,000 deaths
'"/>




Page: 1 2 3

Related medicine news :

1. Closing In On the Breast Cancer Gene
2. Brain Networks Strengthened by Closing Ion Channels
3. Lethal Heart Condition linked To Cocaine Use
4. Toll-like Receptor (Tlr3) Attachment Leads To Lethal Encephalitis
5. How Lethal Is The H5N1?
6. Whirlpool Bath Tubs Contain Potentially Lethal Bacterial Strains
7. Mineral Water Stored In Plastic Containers For Long Could Be Lethal
8. Echocardiography-Guided Genetic Test Could Improve Screening For Lethal Heart Condition
9. Elements In Grape fruit Juice Combine Lethally with Certain Drugs, leading to potentially dangerous side effects, study.
10. Warning! Working For Long Hours On Your Computer Can Be Lethal
11. "Serious Failings" Led To Spread Of Lethal Hospital Bug
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Closing Lethal Heart Rhythm Young Athletes

(Date:6/30/2015)... ... 2015 , ... Lecrae is quickly developing into one of the biggest music ... New York Times to Billboard Magazine and Variety, among others. His transparency and ... why so many people are taking notice. , “We are very excited about this ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... be held October 28-31, 2015 at Disney’s Coronado Springs Resort in Lake Buena ... and networking. Each year, this premiere event for psychiatric-mental health nursing draws more ...
(Date:6/30/2015)... ... 2015 , ... Izenda is proud to acknowledge the hard ... an accredited American educational institution through its scholarship program. , In today's Age ... environment, political campaigns, and a variety of other worldwide trends. Modern day technology ...
(Date:6/30/2015)... ... June 30, 2015 , ... Americans report feeling more ... buzzer on Monday mornings, which puts stressed out people right over the edge. ... 22% suffering from sleep deprivation every night. Sleeping pills now lead the list of ...
(Date:6/30/2015)... ... June 30, 2015 , ... Scott Purdy, the spokesperson for ... Provider XO. Scott Purdy stated that the XO stands for eXtra Operability (XO) which ... the workflow processes of the Revenue Cycle. , Provider XO, based in Cleveland ...
Breaking Medicine News(10 mins):Health News:Hands of Hope to Present Grammy Award-Winner Lecrae in Concert this August 2Health News:Hands of Hope to Present Grammy Award-Winner Lecrae in Concert this August 3Health News:American Psychiatric Nurses Association 29th Annual Conference: Continuing Education and Collaboration in Psychiatric-Mental Health and Nursing 2Health News:American Psychiatric Nurses Association 29th Annual Conference: Continuing Education and Collaboration in Psychiatric-Mental Health and Nursing 3Health News:Izenda Offers Embedded BI and Analytics Scholarship 2Health News:Izenda Offers Embedded BI and Analytics Scholarship 3Health News:Wake UP Happy and Sleep Soundly with Famous Experts with My Wake UP Call® Motivational Alarm Clock® Messages and My Good Night Messages™ - Now Available at Audible! 2Health News:Wake UP Happy and Sleep Soundly with Famous Experts with My Wake UP Call® Motivational Alarm Clock® Messages and My Good Night Messages™ - Now Available at Audible! 3Health News:Dephinitive Systems Is Getting a New Name 2
... a third of American,adults take some type of multivitamin ... is better health, even though there is no firm ... one thing, but the presence of,harm is another: A ... concluded that there was an increased prostate cancer risk ...
... to Stethoscope, the distinguished public lecture series organized by ... (MUHC), is embarking on a second season. "Again this ... on a journey into a possible future, when current ... declared Dr. Arthur T. Porter, Director General of the ...
... The Russell,Investment Group has advised Protalix Biotherapeutics ... float weight adjustment effective after the close of,trading ... Russell 2000,Russell 2000 Growth, Russell 2500, Russell 2500 ... Growth, Russell Small Cap,Completeness and the Russell Small ...
... Sept. 28 Transcept,Pharmaceuticals, Inc., a specialty pharmaceutical ... drugs, today announced,that Glenn A. Oclassen, President and ... 2007 BIO Investor Forum at the Palace Hotel ... 3:00 PM Pacific Time. About Transcept Pharmaceuticals ...
... Doctors need to be more proactive in diagnosing the condition, ... in seven women suffers from depression before, during or after ... can be devastating to the mother, her baby and her ... of The American Journal of Psychiatry . , ...
... M. Williams Speak Out on Mental Health Crisis,Facing ... Experts in mental,health, Members of Congress and other ... Caucus Foundation,s 2007 Annual,Legislative Conference to shed light ... Needs." Rep. Julia Carson (D - IN) together,with ...
Cached Medicine News:Health News:Excessive Multivitamin Use May Raise Risk for Prostate Cancer, from Harvard Men's Health Watch 2Health News:Russell Investment Group Advises Protalix Biotherapeutics of Index Adjustment 2Health News:15% of Women Struggle With Pregnancy-Related Depression 2Health News:15% of Women Struggle With Pregnancy-Related Depression 3Health News:Black America Urged to Confront Its Secret Pain: Depression 2Health News:Black America Urged to Confront Its Secret Pain: Depression 3Health News:Black America Urged to Confront Its Secret Pain: Depression 4Health News:Black America Urged to Confront Its Secret Pain: Depression 5
(Date:6/30/2015)... June 30, 2015  Today, the National Mobility Equipment ... 2015 National Mobility Awareness Month Local Heroes Contest on ... online entries that received 1.3 million votes. The sponsors ... Toyota Mobility , and Valley Honda Dealers ... and Vantage Mobility International (VMI) and ...
(Date:6/30/2015)... Calif. , June 30, 2015  Avanir ... PRISM II study showing that treatment with NUEDEXTA ... reduction in symptoms of pseudobulbar affect (PBA) in ... PBA is a distressing condition characterized by sudden ... from certain neurologic diseases or brain injury. PRISM ...
(Date:6/30/2015)... Minn. , June 30, 2015  EnteroMedics Inc. ... devices that use neuroblocking technology to treat obesity, metabolic ... its previously announced public offering  of 40,229,886 units. Each ... of a Series A warrant to purchase one share ... warrant to purchase one share of common stock, at ...
Breaking Medicine Technology:NMEDA Announces National Contest Winners 2NMEDA Announces National Contest Winners 3Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 2Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 3Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 4Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 5Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 6Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 7EnteroMedics Inc. Announces Pricing of $35.0 Million Public Offering of Common Stock and Warrants 2EnteroMedics Inc. Announces Pricing of $35.0 Million Public Offering of Common Stock and Warrants 3