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Clopidogrel Allergy Can Be Tackled By Methodical Desensitization

ensitization protocol, which was developed by University of Iowa allergist Mary Beth Fasano, MD. While being monitored in the cardiac intensive care unit, patients were first given a dose of clopidogrel so small it had to be mixed into a drinkable solution. Every 15 minutes over the next several hours they received an additional, higher dose of the drug, until they were able to tolerate a target dose of 75 mg. Altogether, they received nine clopidogrel doses totaling 150 mg.

Patients who developed allergy symptoms during the desensitization process were treated with antihistamines and other anti-allergy medications. All patients were able to complete desensitization and safely take a daily 75-mg dose of clopidogrel at home without experiencing delayed allergic reactions.

Dr. Walker noted that patients who had the most severe form of allergic reaction to clopidogrel--anaphylactic shock--were excluded from the study; therefore, the safety and effectiveness of the desensitization protocol has not been established in such patients.

Source: Eurekalert
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