Navigation Links
Clopidogrel Allergy Can Be Tackled By Methodical Desensitization

A study that is to be presented at the 29th Annual Scientific Sessions of the Society for Cardiovascular Angiography and Interventions (SCAI) says that following// a methodical desensitization protocol might help patients who are allergic to anti-clotting medication that is vital to prevent the formation of new blockages in coronary stents.

"Allergic reactions can be quite frightening to patients and physicians, and can lead to discontinuation of the medication," said the study's lead author, Nicholas E. Walker, MD, a cardiology fellow at the University of Iowa, Iowa City. "We showed we could successfully and safely desensitize patients who had just recently had a drug-eluting stent placed. That's a critical population to manage."

Perhaps two out of every hundred patients treated with the anti-clotting medication clopidogrel develop an allergic reaction marked by rash, itching, hives, or swelling of the tongue and airway. A small number of patients even develop an anaphylactic reaction and go into shock.

Physicians generally discontinue a medication that provokes an allergic reaction and prescribe an alternative. However, in the case of clopidogrel, substitute medications are either just as likely to provoke allergy symptoms or markedly less effective. Stopping the medication may be riskier than continuing it: Patients who do not take clopidogrel after stenting--particularly after receiving a drug-eluting stent--face approximately three times the risk of a blood clot blocking the stent and causing a heart attack.

"With widespread use of drug-eluting stents, it's going to be more common to see allergic reactions to clopidogrel, and more critical that we find a way to keep patients on the medication," said Phillip A. Horwitz, MD, a professor of medicine and an interventional cardiologist at the University of Iowa Hospitals and Clinics.

Eight patients with clopidogrel hypersensitivity were treated with the des ensitization protocol, which was developed by University of Iowa allergist Mary Beth Fasano, MD. While being monitored in the cardiac intensive care unit, patients were first given a dose of clopidogrel so small it had to be mixed into a drinkable solution. Every 15 minutes over the next several hours they received an additional, higher dose of the drug, until they were able to tolerate a target dose of 75 mg. Altogether, they received nine clopidogrel doses totaling 150 mg.

Patients who developed allergy symptoms during the desensitization process were treated with antihistamines and other anti-allergy medications. All patients were able to complete desensitization and safely take a daily 75-mg dose of clopidogrel at home without experiencing delayed allergic reactions.

Dr. Walker noted that patients who had the most severe form of allergic reaction to clopidogrel--anaphylactic shock--were excluded from the study; therefore, the safety and effectiveness of the desensitization protocol has not been established in such patients.

Source: Eurekalert
'"/>




Related medicine news :

1. Combination of Clopidogrel-aspirin is better for preventing stroke than only aspirin
2. Allergy Risk Increased by Kerosene Use
3. Infant Fevers Found to Reduce Allergy Risk Later In Life
4. A Common Cause Of Allergy That Goes Unnoticed
5. Laser Surgery for Allergy
6. The Efficacy Of Allergy Shots Questioned
7. Oral Edible vaccine for Allergy Vaccines
8. Tattoo Wearers Are More Prone To Allergy Risks
9. A Sneak Preview of Human’s Susceptibility to Auto Immune Disease, Allergy, Asthm
10. Allergy Alarm: Sams Choice Milk Chocolate Turns Bitter with Undisclosed Nuts
11. Hope for Dust Mite Allergy Sufferers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... San Francisco, CA (PRWEB) , ... October 12, ... ... and Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus ... sleep apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: , ... to enable prevention of a major side effect of chemotherapy in children. Cisplatin ... patients. For cisplatin, hearing loss is FDA listed on-label as a dose limiting ...
(Date:10/12/2017)... ... , ... Leading pediatric oncology experts at Children’s National Health System ... of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of the ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations (HLI), creator ... tool, and the Cancer Patient Education Network (CPEN), an independent professional organization that ... new strategic alliance. , As CPEN’s strategic partner, HLI will help support ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... WESTWOOD, Mass. , Oct. 4, 2017  According to the Centers ... by the end of October . PhysicianOne Urgent Care is helping communities ... Westchester, NY , by offering no-cost* flu shots through ... , as mandated by certain health insurance regulations. ... The best time to get a flu shot is by ...
(Date:10/2/2017)... Oct. 2, 2017  Eli Lilly and Company (NYSE: ... for the third quarter of 2017 on Tuesday, October ... on that day with the investment community and media ... The conference call will begin at 9 a.m. Eastern ... a live webcast of the conference call through a ...
(Date:10/2/2017)... The Rebound mobile app is poised to become a vital ... prescription drug addiction. The app empowers users to develop an ... their dosage in a safe, controlled manner while maximizing well-being. ... 100,000 people to sign up will enjoy 3 months of ... ...
Breaking Medicine Technology: