Navigation Links
Clopidogrel Allergy Can Be Tackled By Methodical Desensitization

A study that is to be presented at the 29th Annual Scientific Sessions of the Society for Cardiovascular Angiography and Interventions (SCAI) says that following// a methodical desensitization protocol might help patients who are allergic to anti-clotting medication that is vital to prevent the formation of new blockages in coronary stents.

"Allergic reactions can be quite frightening to patients and physicians, and can lead to discontinuation of the medication," said the study's lead author, Nicholas E. Walker, MD, a cardiology fellow at the University of Iowa, Iowa City. "We showed we could successfully and safely desensitize patients who had just recently had a drug-eluting stent placed. That's a critical population to manage."

Perhaps two out of every hundred patients treated with the anti-clotting medication clopidogrel develop an allergic reaction marked by rash, itching, hives, or swelling of the tongue and airway. A small number of patients even develop an anaphylactic reaction and go into shock.

Physicians generally discontinue a medication that provokes an allergic reaction and prescribe an alternative. However, in the case of clopidogrel, substitute medications are either just as likely to provoke allergy symptoms or markedly less effective. Stopping the medication may be riskier than continuing it: Patients who do not take clopidogrel after stenting--particularly after receiving a drug-eluting stent--face approximately three times the risk of a blood clot blocking the stent and causing a heart attack.

"With widespread use of drug-eluting stents, it's going to be more common to see allergic reactions to clopidogrel, and more critical that we find a way to keep patients on the medication," said Phillip A. Horwitz, MD, a professor of medicine and an interventional cardiologist at the University of Iowa Hospitals and Clinics.

Eight patients with clopidogrel hypersensitivity were treated with the des ensitization protocol, which was developed by University of Iowa allergist Mary Beth Fasano, MD. While being monitored in the cardiac intensive care unit, patients were first given a dose of clopidogrel so small it had to be mixed into a drinkable solution. Every 15 minutes over the next several hours they received an additional, higher dose of the drug, until they were able to tolerate a target dose of 75 mg. Altogether, they received nine clopidogrel doses totaling 150 mg.

Patients who developed allergy symptoms during the desensitization process were treated with antihistamines and other anti-allergy medications. All patients were able to complete desensitization and safely take a daily 75-mg dose of clopidogrel at home without experiencing delayed allergic reactions.

Dr. Walker noted that patients who had the most severe form of allergic reaction to clopidogrel--anaphylactic shock--were excluded from the study; therefore, the safety and effectiveness of the desensitization protocol has not been established in such patients.

Source: Eurekalert

Related medicine news :

1. Combination of Clopidogrel-aspirin is better for preventing stroke than only aspirin
2. Allergy Risk Increased by Kerosene Use
3. Infant Fevers Found to Reduce Allergy Risk Later In Life
4. A Common Cause Of Allergy That Goes Unnoticed
5. Laser Surgery for Allergy
6. The Efficacy Of Allergy Shots Questioned
7. Oral Edible vaccine for Allergy Vaccines
8. Tattoo Wearers Are More Prone To Allergy Risks
9. A Sneak Preview of Human’s Susceptibility to Auto Immune Disease, Allergy, Asthm
10. Allergy Alarm: Sams Choice Milk Chocolate Turns Bitter with Undisclosed Nuts
11. Hope for Dust Mite Allergy Sufferers
Post Your Comments:

(Date:11/30/2015)... ... November 30, 2015 , ... During the National ... caregivers and held two webinars on topics of ‘Medical and Palliative Care Decisions,’ ... at . , With a loved one's diagnosis of mesothelioma, the ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... . The directory is specialized and only includes chiropractic clinics in the US. ... competent and trustworthy alternative health practitioner when back pain sets in. When people ...
(Date:11/30/2015)... ... November 30, 2015 , ... In an effort ... the Word of Life Christian Church of Flint, MI, hosted a family-oriented evening ... 1.25 ton pile of candy dubbed “Candy Mountain”. , A Forever Recovery, a ...
(Date:11/30/2015)... VA (PRWEB) , ... November 30, 2015 , ... ... Foundation kicked off its annual fundraising campaign to raise funds for its research, ... raises approximately 10% of the organization’s annual funding. , The Mesothelioma Applied Research ...
(Date:11/30/2015)... ... November 30, 2015 , ... The ... in Dallas, TX, on January 29 and 30, 2016. The course welcomes dental ... of their practices, to learn how to better succeed in the modern dental ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 30, 2015 Diplomat Pharmacy, Inc. (NYSE: ... the Detroit Free Press as a Top Workplace , ... to work for in 2015. ... 100 winners annually, based on employee surveys rating company leadership, ... Workplaces are based solely on employee feedback. The survey is ...
(Date:11/30/2015)... , November 30, 2015 global cell ... of US$6.1 bn to US$11.3 bn by 2022 at a CAGR ... is expected to grow from its 2013 value of US$6.1 bn ... --> Transparency Market Research has announced the release of ... According to the report, titled ,Cell Culture Market - Global Industry ...
(Date:11/30/2015)... and BOCA RATON, Fla. , ... the Commercialization of Public Research (the Institute) announced ... KynderMed , a medical device start-up company with ... new company creation based on publicly-funded research, and bridges ... Florida -based universities and research institutions. ...
Breaking Medicine Technology: