Navigation Links
Clock Gene Plays Role in Weight Gain, Study Finds

Scientists at the University of Virginia and the Medical College of Wisconsin have discovered that a gene that participates in the regulation of the bodys biological rhythms may also be a major control in regulating metabolism.

Their finding shows that mice lacking the gene Nocturnin, which is regulated by the circadian clock in the organs and tissues of mammals, are resistant to weight gain when put on a high fat diet and also are resistant to the accumulation of fat in the liver. This new understanding of weight gain could potentially lead to therapies for inhibiting obesity and for treating its effects on health.

Its been known for some time that there are many links between the circadian clock and various aspects of physiology and metabolism, said Carla Green, the studys lead author and an associate professor of biology at the University of Virginia. This study suggests that Nocturnin is part of the network that the circadian clock uses to control important aspects of metabolism. A better understanding of Nocturnins function could eventually lead to medical treatments that could counteract the problems of obesity, which has become a major issue in modern society.

Biological clocks are the bodys internal timekeepers that regulate organs and activity/rest cycles by controlling energy levels, alertness, growth, moods and the effects of aging. Research in this field has many health implications for dealing with aging, jet lag, sleep disorders, shift work and dieting.

Green and her colleagues used regular mice and genetically altered mice in which the Nocturnin gene was knocked out. The Nocturnin-deficient mice were divided into two groups; one group fed a normal diet, the other a very high fat diet. A group of normal mice were also fed a high fat diet.

The researchers found that both groups of the genetically altered mice maintained normal weight and activity levels, and, of particular interest, the ones fed the high fat diet gained only slight weight even over long periods of time. The normal mice on the high fat diet, however, ballooned, gaining more than twice the weight of the Nocturnin-deficient mice. And when the mice were dissected, the researchers discovered that the normal mice had, as expected, large concentrations of fat on their livers, whereas the altered mice had normal levels of fat in their livers.

We were quite amazed at what we found, Green said. We thought that over time, as we continued to feed the mutant mice the high fat diet, that they would eventually gain weight at some expected rate, but it never happened. These mice continued to stay slim while the normal mice nearly doubled in weight and developed fatty livers.

Green said it is possible that, after a great deal of further research, a drug possibly could be developed that would inhibit Nocturnin and reduce the risk of developing obesity.

Clock genes in the bodys organs operate in conjunction with a central time keeper in the brain, the hypothalamic suprachiasmatic nucleus, but also work somewhat independently, resulting in a complex system of oscillators regulating various functions of the body.

Scientists are working to better understand how the genes and proteins of the circadian clock in mammals affect not only activity cycles but also metabolism, which are tied to feeding cycles. Circadian rhythms were set in motion early in the history of life on the planet, and tied through evolution to the astronomical cycles that effect Earths environment, the rise and setting of the sun, and the passing of seasons.


'"/>




Related medicine news :

1. Biological Clock Could Be Re-Set: Study
2. Sunglasses Can Really Pull a Fast One on the Biological Clock, and Set a Lag in the Build Up Of Jet Lag
3. An Alarm Clock to Wake You up Refreshed
4. Artificial Light May Damage Biological Clock In Premature Babies
5. Model of Internal Clocks Reveals How Jet Lag Disrupts the System
6. Researchers Investigate Gene Linked With Circadian Liver Clock
7. Reset Your Biological Clock and Prevent Heart Attack!
8. Circadian Clocks Triggered Chemical Reactions may Be Behind Jet Lag
9. Chennai Plays Hosts To The Diabetes World Congress
10. Chennai Plays Hosts To The Diabetes World Congress
11. Brain Plays Vital Role In Maintaining Bone Density
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... 12, 2017 , ... Planet Fitness, one of the largest and fastest growing ... open a flagship location in Covington, LA at 401 N. U.S. Highway 190, in ... to Office Depot in the Holiday Square shopping center. Its location allows it to ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( ... today the introduction of an innovative new design of the shoulder pad. The ... get maximum comfort while controlling your pain while using cold therapy. By utilizing ice ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized health ... expanded their existing home health joint venture through an agreement, effective October 1, ... joint venture home health company with Asante, delivering clinically integrated care, for the ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Restoration, has recently contributed a medical article to the newly revamped Cosmetic ... Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Leading pediatric oncology ... in Washington, D.C., for the 49th Congress of the International Society of Paediatric ... President of the Center for Cancer and Blood Disorders at Children’s National, ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... 2017  In response to the nationwide opioid ... Surgeons (AAOMS) released prescribing recommendations that urge ibuprofen ... as a first-line therapy to manage a patient,s ... Recognizing the value and importance of ... Prescribing: Acute and Postoperative Pain Management" stresses that ...
(Date:10/2/2017)... , Oct. 2, 2017 Diplomat Pharmacy, ... 8th Day Software and Consulting, LLC , and named ... 8th Day Software, based in Tennessee , ... 8th Day expands EnvoyHealth,s service offerings for health care ... "In an interoperable ...
(Date:10/2/2017)... COPENHAGEN, Denmark , Oct. 2, 2017 The ... tool in the struggle to reverse the tide of prescription ... plan for regulating their medicine intake and stepping down their ... is set to launch in December 2017; the first 100,000 ... access. Learn more at http://www.rebound-solution.com/ ...
Breaking Medicine Technology: