Navigation Links
Clock Gene Plays Role in Weight Gain, Study Finds

Scientists at the University of Virginia and the Medical College of Wisconsin have discovered that a gene that participates in the regulation of the bodys biological rhythms may also be a major control in regulating metabolism.

Their finding shows that mice lacking the gene Nocturnin, which is regulated by the circadian clock in the organs and tissues of mammals, are resistant to weight gain when put on a high fat diet and also are resistant to the accumulation of fat in the liver. This new understanding of weight gain could potentially lead to therapies for inhibiting obesity and for treating its effects on health.

Its been known for some time that there are many links between the circadian clock and various aspects of physiology and metabolism, said Carla Green, the studys lead author and an associate professor of biology at the University of Virginia. This study suggests that Nocturnin is part of the network that the circadian clock uses to control important aspects of metabolism. A better understanding of Nocturnins function could eventually lead to medical treatments that could counteract the problems of obesity, which has become a major issue in modern society.

Biological clocks are the bodys internal timekeepers that regulate organs and activity/rest cycles by controlling energy levels, alertness, growth, moods and the effects of aging. Research in this field has many health implications for dealing with aging, jet lag, sleep disorders, shift work and dieting.

Green and her colleagues used regular mice and genetically altered mice in which the Nocturnin gene was knocked out. The Nocturnin-deficient mice were divided into two groups; one group fed a normal diet, the other a very high fat diet. A group of normal mice were also fed a high fat diet.

The researchers found that both groups of the genetically altered mice maintained normal weight and activity levels, and, of particular interest, the ones fed the high fat diet gained only slight weight even over long periods of time. The normal mice on the high fat diet, however, ballooned, gaining more than twice the weight of the Nocturnin-deficient mice. And when the mice were dissected, the researchers discovered that the normal mice had, as expected, large concentrations of fat on their livers, whereas the altered mice had normal levels of fat in their livers.

We were quite amazed at what we found, Green said. We thought that over time, as we continued to feed the mutant mice the high fat diet, that they would eventually gain weight at some expected rate, but it never happened. These mice continued to stay slim while the normal mice nearly doubled in weight and developed fatty livers.

Green said it is possible that, after a great deal of further research, a drug possibly could be developed that would inhibit Nocturnin and reduce the risk of developing obesity.

Clock genes in the bodys organs operate in conjunction with a central time keeper in the brain, the hypothalamic suprachiasmatic nucleus, but also work somewhat independently, resulting in a complex system of oscillators regulating various functions of the body.

Scientists are working to better understand how the genes and proteins of the circadian clock in mammals affect not only activity cycles but also metabolism, which are tied to feeding cycles. Circadian rhythms were set in motion early in the history of life on the planet, and tied through evolution to the astronomical cycles that effect Earths environment, the rise and setting of the sun, and the passing of seasons.


'"/>




Related medicine news :

1. Biological Clock Could Be Re-Set: Study
2. Sunglasses Can Really Pull a Fast One on the Biological Clock, and Set a Lag in the Build Up Of Jet Lag
3. An Alarm Clock to Wake You up Refreshed
4. Artificial Light May Damage Biological Clock In Premature Babies
5. Model of Internal Clocks Reveals How Jet Lag Disrupts the System
6. Researchers Investigate Gene Linked With Circadian Liver Clock
7. Reset Your Biological Clock and Prevent Heart Attack!
8. Circadian Clocks Triggered Chemical Reactions may Be Behind Jet Lag
9. Chennai Plays Hosts To The Diabetes World Congress
10. Chennai Plays Hosts To The Diabetes World Congress
11. Brain Plays Vital Role In Maintaining Bone Density
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... California (PRWEB) , ... June 25, 2016 , ... "With ... fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... customizable and all within Final Cut Pro X . Simply select a ProHand ...
(Date:6/25/2016)... Long Beach, CA (PRWEB) , ... June 25, 2016 , ... ... from UCLA with Magna Cum Laude and his M.D from the David Geffen School ... San Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , Belgium , June ... MKT: VNRX), today announced the appointment of Dr. ... of Directors as a Non-Executive Director, effective June ... Company,s Audit, Compensation and Nominations and Governance Committees.  ... Dr. Futcher will provide independent expertise and strategic ...
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... , June 23, 2016 Research ... Pharma News Issue 52" report to their offering. ... in influenza treatment creates a favourable commercial environment for MedImmune ... growing patient base that will serve to drive considerable growth ... vaccine would serve to cap sales considerably, but development is ...
Breaking Medicine Technology: