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Clinical-trials Show Increased Therapeutic Activity of Pycnogenol than Daflon

p supplemented daily for eight weeks. Patients who supplemented with Pycnogenol? received either 150 mg or 300 mg, while Daflon? patients supplemented with 1000 mg.

Ankle swelling was measured before 10 a.m. to avoid the swelling effect of standing and again after 30 minutes of resting with feet elevated. Measurements were taken at the beginning of the study and after four and eight weeks of treatment. A composite, analogue score based on signs and symptoms (edema, pain, restless limbs, subjective swelling, and skin alterations/redness) was recorded by patients. A second evaluation of edema was made by another physician.

After eight weeks of treatment, patients who supplemented with Pycnogenol? experienced decreased ankle swellings by 35 percent, while Daflon treatment decreased ankle swelling by 19 percent. A composite score for edema including pain, restless legs, feeling of heavy swollen legs, and skin alterations was found to be decreased with Pycnogenol? by 64%, whereas Daflon? was only half as effective, lowering the composite edema score by 32%.

The transdermal oxygen and carbon dioxide concentration in the lower legs was estimated with small sensors attached to the skin. Pycnogenol? treatment was found to significantly increase tissue oxygen and lower CO2, suggesting a considerable improvement in blood circulation to the legs. Daflon?, in contrast, did not yield any significant effect on the tissue oxygenation and apparently does not improve blood circulation to the legs.

"Interestingly, this study demonstrated that supplementation with a very high dosage of 300 mg Pycnogenol? a day did not yield significantly better effects than treatment with 150 mg Pycnogenol?, with the exception of the composite edema score, which improved better with the higher dosage," said Rohdewald.

Continuous stretching from CVI permanently enlarges veins. Past studies have shown that treating edema with Pycnogenol? prev
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