Navigation Links
Clinical Trials of New Drug Febuxostat Show Promise in Gout Treatment

A new drug called febuxostat has been found to reduce plasma levels of uric acid more effectively in Gout than the currently used drug allopurinol. If the results of the clinical trial are successful//, then it would mean the end of a 40 year search for successful treatment of Gout.

Gout is characterized by accumulation and deposition of needle shaped uric acid crystals in the joints, thereby leading to inflammation and pain. Progressively, it leads to a condition called ‘Gouty arthritis’ and is associated by a significant reduction in joint mobility.

The only existing standard treatment for Gout is administration of allopurinol, which reduces the levels of uric acid production by blocking certain key steps in uric acid synthesis. In addition, it also decreases the plasma levels of uric acid over a period of time.

The study was conducted amongst a group of 762 patients, diagnosed to suffer from Gout and is believed to be the largest clinical trial ever done on patients with Gout. The mechanism of action of Febuxostat is very similar to allopurinol.

The study participants were either given allopurinol or febuxostat (two different doses) as a form of treatment, the goal of which was to reduce plasma uric acid levels by as much as 6 mg/dl. Allopurinol treatment was taken by 21% of the members, followed by 53 and 62% who took 80 and 120mg of febuxostat respectively.

At the end of the study, it was found that the new drug was more effective than allopurinol when used for more than a year, as revealed by statistical tests. However, a large number of patients were found to discontinue from the study due to the high incidence of adverse effects. The main site of drug metabolism is the liver which facilitates administration of the drug to patients with compromised kidney function as well.

The drug has not yet been approved by the U.S. Food and Drug Administration agency (FDA) for therapeutic use. More studies are clearly indicated to determine the long term clinical benefits of the new drug, taking into critical consideration the safety.
'"/>




Related medicine news :

1. Clinical trials need to be more frank
2. Physicians Lack Clinical Guidelines For Treating Elderly With Multiple Illnesses
3. The Growing Rise In Clinical Research Could Lead To A Compromise In Quality Of Research And Ethics
4. Clinical Comparisons Between ADHD Drugs Are Less
5. A Novel System For Clinical Banking Of Umbilical Cord Blood
6. Clinical Renal Trails Do Not Have Sufficient Women Participants
7. Clinical Trials Of New Anti-Cancer Drug To Be Initiated In New Zealand
8. Green Tea Consumption Found To Improve Clinical Outcome In Cancer Patients
9. Cancer Clinical Research in India
10. New Generation Clinical Trials Could Save Time And Money, Improve Patient Care
11. Clinical Impact of Activity and Abdominal Pressure on Pelvic Floor Dysfunction Need to Be Further Analyzed
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/27/2017)... ATLANTA, Ga. (PRWEB) , ... July 27, 2017 , ... ... Man native Sam Brand to the men’s pro squad as a stagiaire for the ... to make his professional debut on July 31st at the Tour of Utah. , ...
(Date:7/26/2017)... ... ... Capillus, LLC has announced the redesign of their FDA-cleared low-level laser (light) ... a more comfortable, adaptable fit and is available for purchase immediately. , Carlos ... therapy caps intended to improve both user experience and hair regrowth. , “Our ...
(Date:7/26/2017)... Ca (PRWEB) , ... July 26, 2017 , ... A ... lyophilization processes. Inconsistent results freeze drying samples and a lengthy freeze dry cycle are ... webinar will discuss freeze drying techniques, as well as new accessories and advancements in ...
(Date:7/26/2017)... ... , ... It's time to sign up for the new One-A-Month Essential Oil Club ... founder of Sublime Naturals and author of numerous books on essential oils. , ... the 5th. , Two items are included in the December mailing. , ...
(Date:7/26/2017)... , ... July 26, 2017 , ... ... and cats has opened in Jupiter. The state of the art center ... class leading treatments with a goal of providing heart patients longer lives. , ...
Breaking Medicine News(10 mins):
(Date:7/26/2017)... LOVELAND, Colo. , July 26, 2017 ... Tristan Guttridge and the Bimini SharkLab to custom design the ... diagnostic images of sharks in their native habitat. In ... for Discovery Channel,s Shark Week, Dr. Guttridge approached ... to take pregnancy diagnosis directly to hammerhead sharks underwater. ...
(Date:7/26/2017)... July 26, 2017 The Galien Foundation ... USA Award Nominees. Counted among the ... Award recognizes outstanding biomedical and technology product achievement that improves ... To qualify, each candidate must be U.S. Food and Drug ... and demonstrate tremendous potential to impact human health. Sales data ...
(Date:7/24/2017)... , July 24, 2017 IBM (NYSE: IBM ... Magic Quadrant for Solid-State Arrays (SSA) for the fourth year ... According to Gartner, "Vendors in the Leaders quadrant have ... of Vision. A vendor in the Leaders quadrant has the ... drive the acceptance of new technologies. These vendors demonstrate a ...
Breaking Medicine Technology: