Navigation Links
Citrinin, a fungal toxin, induces apoptosis via mitochondrial pathway

The Mycotoxin citrinin (CTN) is a secondary metabolite produced by several fungal species that belong mainly to the genus Penicillium and Monascus. It is widely considered as a hazard contaminant of foods// and feeds, including corn, wheat, rice, barley and nuts, and is known to be cytotoxic and genotoxic to various mammalian cells. CTN has been suggested as a causative factor in renal disease among poultry, pigs, dogs and rats.

Many fungal toxins, including ochratoxin A, trichothecene, fumonisin B1, are known to trigger cellular apoptosis, which is a highly regulated cellular process, essential for normal development and the maintenance of homeostasis. The cytotoxic effects of these mycotoxins on animal tissues and cultured cells are thought to correlate with their apoptosis-inducing ability.

A recent paper, to be published in Toxicology Letters (available online 23 September 2005), reports that CTN induces apoptosis through the mitochondria-dependent pathway in human promyelocytic leukemia cells (HL-60) and the process is not directly correlated with cellular oxidative stress.

For the study, human promyelocytic leukemia (HL-60) cells were chosen to identify the apoptotic process induced by CTN. Morphological evidence of apoptosis, including nuclei fragmentation and DNA laddering formation, was clearly observed 24 h after exposure to CTN.

The apoptosis triggered by CTN in HL-60 was accompanied by the cytochrome c release from mitochondria to cytoplasm. The presence of antioxidants in cultures did not effectively suppress CTN-induced cytotoxicity and caspase-3 activity.

These findings suggest that CTN induces apoptosis in HL-60 cells by stimulating cytochrome c release followed by activation of multiple caspases, but oxidative stress may not play a role in the apoptotic process.

Researchers from the Chung Shan Medical University, Department of Life Sciences, Taiwan have combined morphological and biochemical techniques to demonstrate that CTN, a frequently found mycotoxin in food and feed, induced apoptosis in HL-60 cells through the intrinsic pathway, and oxidative stress was not directly involved in the apoptotic process.
'"/>




Related medicine news :

1. Pharmaceutical giant offers AIDS related antifungal drug free to 50 countries
2. Pharmaceutical giant offers AIDS related antifungal drug free to 50 countries
3. Need for anti-fungal treatment for asthma
4. Anti-fungal drug - Griseofulvin may help treat cancer
5. Garlic inhibits fungal growth and protects food
6. Anti-fungal Drug Block Angiogenesis
7. Antibiotic induces liver damage in children with E.COLI infections.
8. UV Radiation induces Melanoma
9. High expression of interferon induces lupus disease
10. Plant based fake meat induces repulsive reaction
11. Aspirin induces Cancer Cells To Commit Suicide
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2016)... ... February 11, 2016 , ... Greenfield Insurance Group ... created to assist the people of their local community. The agency pledges to ... community leaders. Their hope is to bring awareness to important local causes with ...
(Date:2/11/2016)... , ... February 11, 2016 , ... ... practice Village Family Practice , will be presenting at the 2016 HIMSS ... Las Vegas, Nev. , During his session, “ Coding for Care: Using ...
(Date:2/11/2016)... , ... February 11, 2016 , ... The annual list ... on evaluation of DataPoint’s team dedication and commitment to the SharePoint ecosystem. ... the annual list. The panel’s goal is to recognize and promote technology entrepreneurship. ...
(Date:2/11/2016)... ... February 11, 2016 , ... From March ... Academy of Dermatology Annual Meeting at the Walter E. Washington Convention Center in ... for both the condition of hyperhidrosis (excessive sweating) and its treatment options. Specifically, ...
(Date:2/11/2016)... CO. (PRWEB) , ... February 11, 2016 , ... ... people have become more actively engaged in health and wellness best practices in ... importance of riding this trend. February is American Heart Month, which acts as ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 11, 2016 Laboratory glassware and ... laboratories. These may range from microscope slides to large ... made from borosilicate glass because of its low weight ... other hand, started gaining popularity over the past decade ... replace glass with plastic in several applications due to ...
(Date:2/11/2016)... 2016 Potrero Medical, Inc., the developer of the ... appointment of George M. Rapier, III , MD, to ... , WellMed is one of the nation,s largest physician ... members in Texas and ... his own internal medicine practice, he has been instrumental to ...
(Date:2/11/2016)... and PORTLAND, Ore. , ... 340B optimization company, is pleased to announce the acquisition ... sole community and rural access hospitals. Along with providing ... of 340B consulting services to assist clients in navigating ... R. Love , CEO of Wellpartner. --> ...
Breaking Medicine Technology: