Navigation Links
Citrinin, a fungal toxin, induces apoptosis via mitochondrial pathway

The Mycotoxin citrinin (CTN) is a secondary metabolite produced by several fungal species that belong mainly to the genus Penicillium and Monascus. It is widely considered as a hazard contaminant of foods// and feeds, including corn, wheat, rice, barley and nuts, and is known to be cytotoxic and genotoxic to various mammalian cells. CTN has been suggested as a causative factor in renal disease among poultry, pigs, dogs and rats.

Many fungal toxins, including ochratoxin A, trichothecene, fumonisin B1, are known to trigger cellular apoptosis, which is a highly regulated cellular process, essential for normal development and the maintenance of homeostasis. The cytotoxic effects of these mycotoxins on animal tissues and cultured cells are thought to correlate with their apoptosis-inducing ability.

A recent paper, to be published in Toxicology Letters (available online 23 September 2005), reports that CTN induces apoptosis through the mitochondria-dependent pathway in human promyelocytic leukemia cells (HL-60) and the process is not directly correlated with cellular oxidative stress.

For the study, human promyelocytic leukemia (HL-60) cells were chosen to identify the apoptotic process induced by CTN. Morphological evidence of apoptosis, including nuclei fragmentation and DNA laddering formation, was clearly observed 24 h after exposure to CTN.

The apoptosis triggered by CTN in HL-60 was accompanied by the cytochrome c release from mitochondria to cytoplasm. The presence of antioxidants in cultures did not effectively suppress CTN-induced cytotoxicity and caspase-3 activity.

These findings suggest that CTN induces apoptosis in HL-60 cells by stimulating cytochrome c release followed by activation of multiple caspases, but oxidative stress may not play a role in the apoptotic process.

Researchers from the Chung Shan Medical University, Department of Life Sciences, Taiwan have combined morphological and biochemical techniques to demonstrate that CTN, a frequently found mycotoxin in food and feed, induced apoptosis in HL-60 cells through the intrinsic pathway, and oxidative stress was not directly involved in the apoptotic process.

Related medicine news :

1. Pharmaceutical giant offers AIDS related antifungal drug free to 50 countries
2. Pharmaceutical giant offers AIDS related antifungal drug free to 50 countries
3. Need for anti-fungal treatment for asthma
4. Anti-fungal drug - Griseofulvin may help treat cancer
5. Garlic inhibits fungal growth and protects food
6. Anti-fungal Drug Block Angiogenesis
7. Antibiotic induces liver damage in children with E.COLI infections.
8. UV Radiation induces Melanoma
9. High expression of interferon induces lupus disease
10. Plant based fake meat induces repulsive reaction
11. Aspirin induces Cancer Cells To Commit Suicide
Post Your Comments:

(Date:11/26/2015)... ... 2015 , ... WorldCare International, Inc., the first company to ... Benefits Conference. The Employee Benefits Conference was hosted by the International Foundation of ... 2015. The conference was held at the Hawaii Convention Center in Honolulu, Oahu, ...
(Date:11/26/2015)... , ... November 26, 2015 ... ... platform for mental health and wellness consultation, has collaborated with Women’s Web ... address their reader’s queries on topics on mental and emotional well-being relationship, ...
(Date:11/25/2015)... OAK BROOK, Ill. (PRWEB) , ... November 25, ... ... sometimes larger and potentially more aggressive than those found on mammography, according to ... cases MRI findings of additional cancers not seen on mammography may necessitate a ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... the perfect dish and pleasing the palates of attendees is of the utmost ... dish to a seasonal get-together, give these recipes a try this holiday season. ...
(Date:11/25/2015)... ... November 25, 2015 , ... Medical ... once again for its stellar workplace culture with the company’s Cincinnati office being ... Medical Solutions’ Cincinnati office was named a finalist in Cincinnati Business Courier’s 13th ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ... the "2016 Future Horizons and Growth Strategies ... Supplier Shares, Country Segment Forecasts, Competitive Intelligence, Emerging ... --> --> This ... the Japanese therapeutic drug monitoring market, including emerging ...
(Date:11/26/2015)... 2015 ) ... "2016 Future Horizons and Growth Strategies in ... Supplier Shares, Country Segment Forecasts, Competitive Intelligence, ... --> ) has announced ... Horizons and Growth Strategies in the German ...
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Drug Monitoring (TDM) Market: Supplier Shares, ... Opportunities"  report to their offering.  ... the addition of the  "2016 Future ...
Breaking Medicine Technology: